Patents by Inventor Masahiro Makuta

Masahiro Makuta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of purifying eicosapentaenoic acid or the ester derivative thereof by fractional distillation
    Patent number: 5215630
    Abstract: The present invention provides a continuous method of purifying eicosapentaenoic acid and esters of eicosapentanoic acid, comprising (a) fractionally distilling a starting mixture containing eicosapentaenoic acid or esters of eicosapentaenoic acid using a system of at least three distillation columns connected in flow arrangement to separate a fraction containing eicosapentaenoic acid or esters of eicosapentaenoic acid and other C.sub.20 fatty acids from a fraction containing lower-number carbon fatty acids and from a fraction containing higher-number carbon fatty acids, and (b) continuously collecting the fraction containing eicosapentaenoic acid or esters of eicosapentaenoic acid, wherein the pressure in the distillation columns is maintained at 10 Torr or below and wherein the bottom temperature of the distillation columns is maintained at 210.degree. C. or below.
    Type: Grant
    Filed: June 4, 1991
    Date of Patent: June 1, 1993
    Assignees: Nippon Suisan Kaisha, Ltd., Kansai Chemical Engineering Co., Ltd.
    Inventors: Kazuhiko Hata, Hideo Noda, Masahiro Makuta
  • Method of purifying eicosapentaenoic acid and its esters
    Patent number: 4377526
    Abstract: A method of purifying eicosapentaenoic acid and esters of eicosapentaenoic acid comprising subjecting a mixture containing eicosapentaenoic acid or an ester of eicosapentaenoic acid to the following steps in either order: (1) urea treatment, where the treatment comprises contacting the mixture with a polar organic solvent containing dissolved urea whereby a solution containing the acid or ester is formed, precipitating urea crystals from the solution, and removing the urea crystals, and (2) fractional distillation.
    Type: Grant
    Filed: December 11, 1981
    Date of Patent: March 22, 1983
    Assignee: Nippon Suisan Kaisha, Ltd.
    Inventors: Takao Fujita, Masahiro Makuta