Patents by Inventor Masahiro Muraguchi
Masahiro Muraguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230313204Abstract: The present invention provides an aptamer that binds to chymase, and contains a common sequence represented by UAACR1N1R2GGGG wherein R1 and R2 are each any one base, and N1 shows 3 to 30 bases (uracil is optionally thymine).Type: ApplicationFiled: April 3, 2023Publication date: October 5, 2023Applicant: RIBOMIC INC.Inventors: Satoko YAMAZAKI, Yosuke NONAKA, Yoshikazu NAKAMURA, Masahiro MURAGUCHI, Kaori MURATA
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Patent number: 11639503Abstract: The present invention provides an aptamer that binds to chymase, and contains a common sequence represented by UAACR1N1R2GGGG wherein R1 and R2 are each any one base, and N1 shows 3 to 30 bases (uracil is optionally thymine).Type: GrantFiled: November 30, 2018Date of Patent: May 2, 2023Assignee: RIBOMIC INC.Inventors: Satoko Yamazaki, Yosuke Nonaka, Yoshikazu Nakamura, Masahiro Muraguchi, Kaori Murata
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Publication number: 20210002644Abstract: The present invention provides an aptamer that binds to chymase, and contains a common sequence represented by UAACR1N1R2GGGG wherein R1 and R2 are each any one base, and N1 shows 3 to 30 bases (uracil is optionally thymine).Type: ApplicationFiled: November 30, 2018Publication date: January 7, 2021Applicant: RIBOMIC INC.Inventors: Satoko YAMAZAKI, Yosuke NONAKA, Yoshikazu NAKAMURA, Masahiro MURAGUCHI, Kaori MURATA
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Patent number: 9012420Abstract: Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.Type: GrantFiled: June 11, 2010Date of Patent: April 21, 2015Assignees: Ribomic Inc., Otsuka Pharmaceutical Co., Ltd.Inventors: Yoshikazu Nakamura, Ling Jin, Satoko Yamazaki, Hisako Ikeda, Masahiro Muraguchi
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Publication number: 20150104811Abstract: The present invention provides a method for pretreatment of a biological sample in the immunoassay of a protein contained in the biological sample. The method includes the steps of: (1) freezing the biological sample at a temperature higher than ?80° C., in particular at ?70° C. or higher; (2) thawing the frozen biological sample; and (3) solubilizing the biological sample using a surfactant.Type: ApplicationFiled: August 10, 2012Publication date: April 16, 2015Inventors: Sei Sasaki, Yasukazu Ohmoto, Toyoki Mori, Fusako Iwata, Masahiro Muraguchi
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Publication number: 20120165401Abstract: Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.Type: ApplicationFiled: June 11, 2010Publication date: June 28, 2012Inventors: Yoshikazu Nakamura, Ling Jin, Satoko Yamazaki, Hisako Ikeda, Masahiro Muraguchi
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Publication number: 20110281284Abstract: According to the present invention, HDGF in the blood of patients with chronic liver disease is measured to diagnose whether the patients have liver cancer. A measurement kit for the diagnosis is also provided.Type: ApplicationFiled: August 7, 2008Publication date: November 17, 2011Applicants: OTSUKA PHARMACEUTICAL CO., LTD, HYOGO COLLEGE OF MEDICINEInventors: Hideji Nakamura, Youichi Yabuuchi, Yasukazu Ohmoto, Toyoki Mori, Masahiro Muraguchi, Keiko Oga, Fusako Iwata, Kaori Murata
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Publication number: 20100040175Abstract: It is possible to realize an ideal software reception device which can demodulate a higher-order modulation signal without losing vector information even if a carrier wave is sampled with a frequency lower than the carrier wave. A sampling frequency is set so that a phase relationship of the sampling point of an alias signal generated by sampling of a carrier with a sampling frequency lower than the carrier wave coincides with a phase relationship of the sampling point of the carrier wave. That is, the sampling frequency is set so that the carrier wave frequency “fc” and the sampling frequency “fs” satisfy the relationship fs=4fc/(4k+1), wherein k is a positive integer. Thus, it is possible to perform undersampling of the carrier wave while holding the vector information and demodulate a higher-order modulation such as QPSK and 64 QAM.Type: ApplicationFiled: February 27, 2008Publication date: February 18, 2010Inventors: Masahiro Muraguchi, Mitsutoshi Kijima, Yudai Inada, Kohei Suzaki
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Publication number: 20080226298Abstract: The present invention has been achieved to provide a novel optical transmission system realizing high-speed optical transmission over greater distance by suppressing waveform degradation caused by mode dispersion and mode transition in a multimode optical transmission line. The optical transmission system of the present invention includes: an optical transmitter for transmitting incoherent light; an excitation mechanism for exciting a predetermined mode in the incoherent light transmitted from the optical transmitter; a multimode optical transmission line for transmitting the incoherent light transmitted from the excitation mechanism; a transmission mechanism for transmitting a predetermined mode in the incoherent light transmitted from the excitation mechanism; and an optical receiver for receiving the incoherent light transmitted from the transmission mechanism or the incoherent light transmitted from the transmission mechanism.Type: ApplicationFiled: September 16, 2004Publication date: September 18, 2008Applicants: Nippon Telegraph and Telephone Corporation, NTT Electronics CorporationInventors: Hiroyuki Fukuyama, Toshihiro Itoh, Satoshi Tunashima, Kimikazu Sano, Koichi Murata, Yohtaro Umeda, Yasuo Tazoh, Hirohiko Sugahara, Hiromu Toba, Masahiro Muraguchi, Senichi Suzuki, Seiji Fukushima, Yoshinori Hibino, Tadashi Sakamoto, Yoshiaki Yamabayashi, Eiji Yoshida, Ryuichi Iwamoto
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Patent number: 5726613Abstract: An active inductor having a greater inductance, low loss, and which is small is provided by the present invention. The active inductor comprises a common source FET and a cascode-connected common gate FET connected thereto for providing unidirectional feedback. The drain electrode of the front FET and the source electrode of the rear FET, consisting of the common gate cascode FET, are connected together. A resistor is connected at one end to this connection. The two terminals of the active inductor correspond to the other end of the resistor and the source electrode of the common source FET. A frequency independent negative resistance is generated in series with the inductance by this configuration. By properly tuning the resistance of the resistor, it is possible to make the impedance viewed from the two terminals to have inductance component only, and therefore an active inductor having less resistance loss is obtained.Type: GrantFiled: January 31, 1996Date of Patent: March 10, 1998Assignee: Nippon Telegraph and Telephone CorporationInventors: Hitoshi Hayashi, Masashi Nakatsugawa, Masahiro Muraguchi
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Patent number: 5606738Abstract: A frequency conversion circuit having at least one transistor with an input terminal and an output terminal. A frequency signal to be converted or a local oscillator (LO) signal is input to the input terminal, and a converted frequency signal is output from the output terminal. A linear feedback circuit allowing at least a radio frequency (RF) signal and the LO signal to feed back is directly connected across the input and output terminals.Type: GrantFiled: February 17, 1995Date of Patent: February 25, 1997Assignee: Nippon Telegraph and Telephone Corp.Inventors: Kiyomitsu Onodera, Masahiro Muraguchi