Patents by Inventor Masahiro Muraguchi

Masahiro Muraguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230313204
    Abstract: The present invention provides an aptamer that binds to chymase, and contains a common sequence represented by UAACR1N1R2GGGG wherein R1 and R2 are each any one base, and N1 shows 3 to 30 bases (uracil is optionally thymine).
    Type: Application
    Filed: April 3, 2023
    Publication date: October 5, 2023
    Applicant: RIBOMIC INC.
    Inventors: Satoko YAMAZAKI, Yosuke NONAKA, Yoshikazu NAKAMURA, Masahiro MURAGUCHI, Kaori MURATA
  • Patent number: 11639503
    Abstract: The present invention provides an aptamer that binds to chymase, and contains a common sequence represented by UAACR1N1R2GGGG wherein R1 and R2 are each any one base, and N1 shows 3 to 30 bases (uracil is optionally thymine).
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: May 2, 2023
    Assignee: RIBOMIC INC.
    Inventors: Satoko Yamazaki, Yosuke Nonaka, Yoshikazu Nakamura, Masahiro Muraguchi, Kaori Murata
  • Publication number: 20210002644
    Abstract: The present invention provides an aptamer that binds to chymase, and contains a common sequence represented by UAACR1N1R2GGGG wherein R1 and R2 are each any one base, and N1 shows 3 to 30 bases (uracil is optionally thymine).
    Type: Application
    Filed: November 30, 2018
    Publication date: January 7, 2021
    Applicant: RIBOMIC INC.
    Inventors: Satoko YAMAZAKI, Yosuke NONAKA, Yoshikazu NAKAMURA, Masahiro MURAGUCHI, Kaori MURATA
  • Patent number: 9012420
    Abstract: Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: April 21, 2015
    Assignees: Ribomic Inc., Otsuka Pharmaceutical Co., Ltd.
    Inventors: Yoshikazu Nakamura, Ling Jin, Satoko Yamazaki, Hisako Ikeda, Masahiro Muraguchi
  • Publication number: 20150104811
    Abstract: The present invention provides a method for pretreatment of a biological sample in the immunoassay of a protein contained in the biological sample. The method includes the steps of: (1) freezing the biological sample at a temperature higher than ?80° C., in particular at ?70° C. or higher; (2) thawing the frozen biological sample; and (3) solubilizing the biological sample using a surfactant.
    Type: Application
    Filed: August 10, 2012
    Publication date: April 16, 2015
    Inventors: Sei Sasaki, Yasukazu Ohmoto, Toyoki Mori, Fusako Iwata, Masahiro Muraguchi
  • Publication number: 20120165401
    Abstract: Provided are an aptamer bound to chymase to inhibit activity of chymase; an aptamer containing a nucleotide sequence represented by X1GAUAGAN1N2UAAX2 wherein X1 and X2 are the same or different and each is A or G, and N1 and N2 are the same or different and each is A, G, C, U or T; a complex containing the aptamer and a functional substance (e.g., affinity substance, labeling substance, enzyme, drug delivery medium, drug and the like); a pharmaceutical or a reagent containing the aptamer or complex; a detection and a purification methods of chymase using the aptamer or complex and the like.
    Type: Application
    Filed: June 11, 2010
    Publication date: June 28, 2012
    Inventors: Yoshikazu Nakamura, Ling Jin, Satoko Yamazaki, Hisako Ikeda, Masahiro Muraguchi
  • Publication number: 20110281284
    Abstract: According to the present invention, HDGF in the blood of patients with chronic liver disease is measured to diagnose whether the patients have liver cancer. A measurement kit for the diagnosis is also provided.
    Type: Application
    Filed: August 7, 2008
    Publication date: November 17, 2011
    Applicants: OTSUKA PHARMACEUTICAL CO., LTD, HYOGO COLLEGE OF MEDICINE
    Inventors: Hideji Nakamura, Youichi Yabuuchi, Yasukazu Ohmoto, Toyoki Mori, Masahiro Muraguchi, Keiko Oga, Fusako Iwata, Kaori Murata
  • Publication number: 20100040175
    Abstract: It is possible to realize an ideal software reception device which can demodulate a higher-order modulation signal without losing vector information even if a carrier wave is sampled with a frequency lower than the carrier wave. A sampling frequency is set so that a phase relationship of the sampling point of an alias signal generated by sampling of a carrier with a sampling frequency lower than the carrier wave coincides with a phase relationship of the sampling point of the carrier wave. That is, the sampling frequency is set so that the carrier wave frequency “fc” and the sampling frequency “fs” satisfy the relationship fs=4fc/(4k+1), wherein k is a positive integer. Thus, it is possible to perform undersampling of the carrier wave while holding the vector information and demodulate a higher-order modulation such as QPSK and 64 QAM.
    Type: Application
    Filed: February 27, 2008
    Publication date: February 18, 2010
    Inventors: Masahiro Muraguchi, Mitsutoshi Kijima, Yudai Inada, Kohei Suzaki
  • Publication number: 20080226298
    Abstract: The present invention has been achieved to provide a novel optical transmission system realizing high-speed optical transmission over greater distance by suppressing waveform degradation caused by mode dispersion and mode transition in a multimode optical transmission line. The optical transmission system of the present invention includes: an optical transmitter for transmitting incoherent light; an excitation mechanism for exciting a predetermined mode in the incoherent light transmitted from the optical transmitter; a multimode optical transmission line for transmitting the incoherent light transmitted from the excitation mechanism; a transmission mechanism for transmitting a predetermined mode in the incoherent light transmitted from the excitation mechanism; and an optical receiver for receiving the incoherent light transmitted from the transmission mechanism or the incoherent light transmitted from the transmission mechanism.
    Type: Application
    Filed: September 16, 2004
    Publication date: September 18, 2008
    Applicants: Nippon Telegraph and Telephone Corporation, NTT Electronics Corporation
    Inventors: Hiroyuki Fukuyama, Toshihiro Itoh, Satoshi Tunashima, Kimikazu Sano, Koichi Murata, Yohtaro Umeda, Yasuo Tazoh, Hirohiko Sugahara, Hiromu Toba, Masahiro Muraguchi, Senichi Suzuki, Seiji Fukushima, Yoshinori Hibino, Tadashi Sakamoto, Yoshiaki Yamabayashi, Eiji Yoshida, Ryuichi Iwamoto
  • Patent number: 5726613
    Abstract: An active inductor having a greater inductance, low loss, and which is small is provided by the present invention. The active inductor comprises a common source FET and a cascode-connected common gate FET connected thereto for providing unidirectional feedback. The drain electrode of the front FET and the source electrode of the rear FET, consisting of the common gate cascode FET, are connected together. A resistor is connected at one end to this connection. The two terminals of the active inductor correspond to the other end of the resistor and the source electrode of the common source FET. A frequency independent negative resistance is generated in series with the inductance by this configuration. By properly tuning the resistance of the resistor, it is possible to make the impedance viewed from the two terminals to have inductance component only, and therefore an active inductor having less resistance loss is obtained.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: March 10, 1998
    Assignee: Nippon Telegraph and Telephone Corporation
    Inventors: Hitoshi Hayashi, Masashi Nakatsugawa, Masahiro Muraguchi
  • Patent number: 5606738
    Abstract: A frequency conversion circuit having at least one transistor with an input terminal and an output terminal. A frequency signal to be converted or a local oscillator (LO) signal is input to the input terminal, and a converted frequency signal is output from the output terminal. A linear feedback circuit allowing at least a radio frequency (RF) signal and the LO signal to feed back is directly connected across the input and output terminals.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: February 25, 1997
    Assignee: Nippon Telegraph and Telephone Corp.
    Inventors: Kiyomitsu Onodera, Masahiro Muraguchi