Abstract: An air conditioning device for a vehicle includes: a refrigeration cycle including a compressor, a condenser, an expansion valve, and an evaporator through which a refrigerant is sequentially flowed; a high-temperature heat medium circuit through which a high-temperature heat medium has exchanged heat with the refrigerant in the condenser is circulated; a low-temperature heat medium circuit through which a low-temperature heat medium has exchanged heat with the refrigerant in the evaporator is circulated; a connection line connecting the high-temperature heat medium circuit to the low-temperature heat medium circuit; vehicle interior heat exchangers allowed to be introduced the heat medium thereinto; and a switching unit which switches an operation state of the air conditioning device to a first mode allowing to connect the vehicle interior heat exchangers to the high-temperature heat medium circuit, a second mode allowing to connect the vehicle interior heat exchangers to the low-temperature heat medium circ

Abstract: A coupling clip includes a clip body that includes a wiper lever anchor portion to be anchored to a coupling shaft provided at a wiper lever assembly supporting a blade rubber, and a wiper arm anchor portion for anchoring a wiper arm. The coupling clip also includes a damper member that is attached to the clip body. When the wiper lever assembly is displaced with respect to the clip body, the damper member is deformed between the wiper lever assembly and the clip body.

Abstract: It is intended to provide a novel compound or a salt thereof, or crystals of the compound or the salt, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl. [Solution] The present invention provides a pyridone derivative having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or a salt thereof, or crystals of the compound or the salt (wherein R1, R2, R3, R4, R5, W, X, Y, and Z are each as defined in the specification).

Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.

Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Abstract: A coupling clip includes a clip body that includes a wiper lever anchor portion to be anchored to a coupling shaft provided at a wiper lever assembly supporting a blade rubber, and a wiper arm anchor portion for anchoring a wiper arm. The coupling clip also includes a damper member that is attached to the clip body. When the wiper lever assembly is displaced with respect to the clip body, the damper member is deformed between the wiper lever assembly and the clip body.

Abstract: Provided is a novel compound or a salt thereof inhibiting MTHFD2 and useful for treating a disease caused by overexpression of MTHFD2, a disease involved in overexpression of MTHFD2 and/or a disease associated with overexpression of MTHFD2. Solution Provided is a sulfonamide derivative having a coumarin skeleton represented by the following formula (I) and having various substituents: wherein R1, R2, R3, R4, R5, R6 and R7 are the same as defined in the specification, and a salt thereof.

Abstract: An object of the present invention is to provide a pharmaceutical agent for the treatment and/or prophylaxis of pediatric osteoporosis without causing bone growth disorder in a subject to be medicated. A pharmaceutical composition for the treatment and/or prophylaxis of pediatric osteoporosis contains an antibody or a functional fragment thereof which binds to Siglec-15 and has activity of suppressing formation of osteoclasts and/or bone resorption by osteoclasts.

Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.

Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.

Abstract: Provided is a novel compound or a salt thereof inhibiting MTHFD2 and useful for treating a disease caused by overexpression of MTHFD2, a disease involved in overexpression of MTHFD2 and/or a disease associated with overexpression of MTHFD2. Solution Provided is a sulfonamide derivative having a coumarin skeleton represented by the following formula (I) and having various substituents: wherein R1, R2, R3, R4, R5, R6 and R7 are the same as defined in the specification, and a salt thereof.

Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.

Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.

Abstract: The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.

Abstract: A water heater attachment method is a method for attaching a water heater body to a wall surface by using an attachment member provided at a rear end of an upper surface of the water heater body. The method includes a first step of inserting a tip of a rod member into a through hole formed in the attachment member, the rod member projecting forward from the wall surface, a second step of sliding the attachment member toward the wall surface along the rod member to shift the water heater body to an attachment position of the wall surface, and a third step of fastening the attachment member to the wall surface by a screw in a state where the attachment member is held by the rod member.

Abstract: A vascular maturation, normalization or stabilization agent, or a Tie-2 activation agent, is provided comprising an extract derived from a plant belonging to the genus Cinnamomum.

Abstract: A water heater attachment method is a method for attaching a water heater body to a wall surface by using an attachment member provided at a rear end of an upper surface of the water heater body. The method includes a first step of inserting a tip of a rod member into a through hole formed in the attachment member, the rod member projecting forward from the wall surface, a second step of sliding the attachment member toward the wall surface along the rod member to shift the water heater body to an attachment position of the wall surface, and a third step of fastening the attachment member to the wall surface by a screw in a state where the attachment member is held by the rod member.

Abstract: Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction are provided. Pyridone derivatives represented by the formula (1) having various substituents or salts thereof, or crystals thereof (where R1, R2, R3, R5, R6, A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.

Abstract: A substrate for growing carbon nanotubes capable of elongating single-walled carbon nanotubes of an average diameter of less than 2 nm is provided. The substrate for growing carbon nanotubes 1 is equipped with a reaction prevention layer 3 formed on a base material 2, a catalyst material layer 4 formed on the reaction prevention layer 3, a dispersion layer 5 formed on the catalyst material layer 4, and a dispersion promotion layer 6 formed on the dispersion layer 5.