Patents by Inventor Masakazu Fukuda
Masakazu Fukuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180133375Abstract: The purpose of the present invention is to provide a pre-filled syringe formulation with staked needle, which contains an antibody at a high concentration and can be produced on an industrial scale in a simple manner without causing clogging. A pre-filled syringe formulation with staked needle, in which a protein solution is packed. The pre-filled syringe formulation is characterized in that a cap formed with a material having low water vapor permeability is provided at the needle.Type: ApplicationFiled: October 30, 2015Publication date: May 17, 2018Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Rieko SHIOZAKI, Yuji YAMANAKA, Mika TAKAHASHI, Tadao YAMAZAKI, Masakazu FUKUDA, Shogo YAMASHITA
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Publication number: 20180038847Abstract: Provided is a method for detecting a stem cell based on an undifferentiated sugar chain marker having a specific sugar chain structure, wherein the stem cell is detected by detecting podocalyxin contained in a culture supernatant or a lysate of cells by a “lectin-antibody sandwich method” using a combination of a lectin and an antibody and having high sensitivity, the method including steps of: contacting the culture supernatant or the lysate, a lectin capable of binding to a sugar chain represented by (Formula 1) or (Formula 2), and an antibody capable of binding to keratan sulfate to form a complex composed of the lectin, podocalyxin and the antibody; and detecting the complex. wherein R1 represents an OH group or any sugar chain and R2 represents an OH group or any sugar chain, protein, lipid, or another molecule. wherein R1 represents an OH group or any sugar chain and R2 represents an OH group or any sugar chain, protein, lipid, or another molecule.Type: ApplicationFiled: December 21, 2015Publication date: February 8, 2018Inventors: Hiroaki TATENO, Masaki WARASHINA, Masakazu FUKUDA, Kazunari HIRAYASU
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Publication number: 20180017480Abstract: A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.Type: ApplicationFiled: September 26, 2017Publication date: January 18, 2018Applicant: SYSMEX CORPORATIONInventors: Masakazu FUKUDA, Masamichi TANAKA, Yousuke TANAKA
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Publication number: 20170362304Abstract: The inventors discovered that viscosity of a protein solution can be estimated by measuring the apparent particle size or apparent molecular weight by a small angle X-ray scattering (SAXS) method or X-ray solution scattering method, which enables measurement of small amounts of samples, and then correlating those measurement results with viscosity of the protein solution.Type: ApplicationFiled: August 20, 2015Publication date: December 21, 2017Applicant: CHUGAI SEIYAKU KABUSHIKI KAISHAInventors: Masakazu Fukuda, Akira Hayasaka, Tomoyuki Igawa, Atsuhiko Maeda, Machiko Fujino
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Publication number: 20170322159Abstract: A cell analyzing method includes measuring cells that are nuclear stained, by a cytometric device, to obtain a histogram of a parameter of a fluorescence signal, where the parameter indicates an amount of DNA in a nucleus of a cell. A number of cells that are distributed in an area where the parameter of the fluorescence signal is larger than normal cells are obtained by a computer having at least one processor. The possibility of cancer is determined based on the obtained number of cells and the histogram.Type: ApplicationFiled: July 14, 2017Publication date: November 9, 2017Inventors: Masaki ISHISAKA, Kazuki KISHI, Masakazu FUKUDA
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Publication number: 20170285000Abstract: Provided are a cell imaging device and a cell imaging method that can shorten the time period of taking images of cells in a liquid sample, compared with conventional techniques. This cell imaging device introduces a urine sample containing cells into an internal space of a sample cell, moves at least one of the sample cell and an objective lens in a second direction while at least one of the sample cell and the objective lens is moved in a first direction, the second direction being different from the first direction, and takes, at a plurality of imaging positions, images of cells contained in the urine sample by means of an imaging unit.Type: ApplicationFiled: June 20, 2017Publication date: October 5, 2017Inventors: Masakazu FUKUDA, Masamichi TANAKA, Yanyan LIU, Ryosuke FUJII, Takumi INUTSUKA, Tomoyuki TSUKAHARA
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Patent number: 9746461Abstract: A urine analyzer capable of operating in a urine measurement mode and a body fluid measurement mode, the urine analyzer includes a specimen preparing section configured to prepare a measurement specimen and a detecting section configured to derive signals of particles in the measurement specimen supplied from the specimen preparing section. A computer and a memory including programs on a computer-readable medium that enable the computer to execute operations to control the specimen preparing section and the detecting section in the urine measurement mode and in the body fluid measurement mode.Type: GrantFiled: February 28, 2014Date of Patent: August 29, 2017Assignee: SYSMEX CORPORATIONInventors: Masakazu Fukuda, Masamichi Tanaka
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Patent number: 9733186Abstract: A cell analysis apparatus includes an optical detection section that accommodates a flow of a measurement sample obtained from a biological sample and a pigment into a flow cell. A light source irradiates the measurement sample flowing in the flow cell and a fluorescence detector detects fluorescence from the measurement sample. A signal processing circuit acquires a value reflecting the height of a waveform of the signal and a value reflecting the length of a ridge line of the waveform of the signal, and a system control section distinguishes between an aggregating cell formed by aggregation of a plurality of cells and a non-aggregating cell, based on the value of the fluorescence signal obtained by the signal processing circuit.Type: GrantFiled: January 27, 2014Date of Patent: August 15, 2017Assignee: SYSMEX CORPORATIONInventors: Masaki Ishisaka, Kazuki Kishi, Masakazu Fukuda
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Patent number: 9625388Abstract: A cell analysis apparatus that can accurately distinguish between an aggregating cell and a non-aggregating cell is provided.Type: GrantFiled: April 19, 2010Date of Patent: April 18, 2017Assignee: SYSMEX CORPORATIONInventors: Masaki Ishisaka, Kazuki Kishi, Masakazu Fukuda
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Patent number: 9500650Abstract: An object of the present invention is to provide a method for evaluating a differentiation status of cells using a culture supernatant of stem cells. Provided is “undifferentiation sugar chain marker” composed of the sugar chain structure “Fuc?1-2Gal?1-3GlcNAc” or “Fuc?1-2Gal?1-3GalNAc” and capable of sensitively determining the undifferentiated state of stem cells using a culture supernatant of stem cells. Also found is BC2LCN lectin or a modified product thereof capable of sensitively recognizing the “undifferentiation sugar chain marker” as excellent “probe for detecting the undifferentiation sugar chain marker” capable of determining the undifferentiation status of cells using a culture supernatant.Type: GrantFiled: October 31, 2012Date of Patent: November 22, 2016Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, WAKO PURE CHEMICAL INDUSTRIES, LTD.Inventors: Hiroaki Tateno, Jun Hirabayashi, Yuzuru Ito, Yasuko Onuma, Makoto Asashima, Atsushi Kuno, Masaki Warashina, Masakazu Fukuda
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Patent number: 9500665Abstract: A sample processing apparatus comprises an aspirating member which comprises a pump at one side and which is configured to aspirate a sample from the other side, a sensor which is configured to sense the presence or absence of a liquid at a predetermined position of the aspirating member, and a controller which is programmed to execute operations. The operations comprise controlling the aspirating member to aspirate a sample, obtaining a first sensing result by the sensor when the aspirating member aspirates a sample, controlling the aspirating member to aspirate air after aspirating a sample, obtaining a second sensing result by the sensor when the aspirating member aspirates air, and detecting an error in the aspirating operation, based on the first sensing result and the second sensing result.Type: GrantFiled: June 26, 2014Date of Patent: November 22, 2016Assignee: SYSMEX CORPORATIONInventors: Masakazu Fukuda, Masamichi Tanaka
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Publication number: 20160291306Abstract: A cell imaging apparatus captures images of cells contained in a liquid specimen comprising: an image capture unit including an objective lens, specimen cells each including an inner space which is capable of holding a liquid specimen and which is elongated in one direction, the specimen cells arranged such that the inner spaces are aligned in a row in a longitudinal direction of the inner spaces, a drive unit that moves at least one of: a) one or more specimen cells; and b) the objective lens; and a controller that controls the drive unit to move at least one of: a) one or more specimen cells; and b) the objective lens in the longitudinal direction and controls the image capture unit to capture images of cells contained in a liquid specimen held in the inner space of each of the specimen cells at multiple image capture positions.Type: ApplicationFiled: March 23, 2016Publication date: October 6, 2016Applicant: SYSMEX CORPORATIONInventors: Masakazu FUKUDA, Yanyan LIU, Toshihiro OOTANI
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Patent number: 9329109Abstract: A cell processing apparatus includes a storage container that contains liquid L including a biological sample; a filter that prevents a first cell C1 in the biological sample from passing and allows a second cell C2 having a smaller diameter than that of the first cell C1 to pass; and a filtration cylinder for separating, in the storage container and via the filter, the liquid L into a first liquid L1 mainly including the first cell C1 and a second liquid L2 mainly including the second cell C2. A measurement target cell filtered by the filter among other cells can be easily collected.Type: GrantFiled: March 6, 2013Date of Patent: May 3, 2016Assignee: Sysmex CorporationInventors: Masakazu Fukuda, Hironori Kobayashi, Junyi Ding, Ryuichiro Ebi, Koki Tajima
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Patent number: 9310557Abstract: A heating device for heating an optical fiber reinforcing member includes fiber holders to hold optical fibers covered with the reinforcing member at a fusion-spliced portion, a heater to heat the reinforcing member, a power supply unit to apply a voltage to the heater, and a controller to control the application of a voltage from the power supply unit to the heater. The controller includes a detecting unit that detects a parameter for determining the amount of heat generation of the heater, a storage unit that stores a plurality of heating conditions that vary depending on the parameter value, and a condition instruction unit that selects any of the plurality of heating conditions in accordance with the parameter value detected by the detecting unit and instructs the power supply unit to apply a voltage to the heater on the basis of the selected heating condition.Type: GrantFiled: July 25, 2013Date of Patent: April 12, 2016Assignee: SEI OPTIFRONTIER CO., LTD.Inventors: Masakazu Fukuda, Kensuke Ito
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Patent number: 9279809Abstract: Provided are a method for accurately evaluating the differentiation status of stem cells by selectively staining only stem cells in an undifferentiated state, and a method for positively isolating only stem cells in an undifferentiated state. Specifically provided is a method for determining differentiation of a cell comprising a step of contacting a test cell with a probe comprising protein (A) or (B) below and a step of detecting the presence of binding of the probe to the test cell. The method for determining differentiation of a cell is capable of detecting the presence or absence of an undifferentiated stem cell in test cells by using a probe that specifically reacts with undifferentiated stem cells and detecting the presence of bonding to the test cell.Type: GrantFiled: February 27, 2013Date of Patent: March 8, 2016Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, WAKO PURE CHEMICAL INDUSTRIES, LTD.Inventors: Hiroaki Tateno, Jun Hirabayashi, Makoto Asashima, Yuzuru Ito, Yasuko Onuma, Masaki Warashina, Masakazu Fukuda
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Publication number: 20150204870Abstract: An object of the present invention is to provide a method for evaluating a differentiation status of cells using a culture supernatant of stem cells. Provided is “undifferentiation sugar chain marker” composed of the sugar chain structure “Fuc?1-2Gal?1-3GlcNAc” or “Fuc?1-2Gal?1-3GalNAc” and capable of sensitively determining the undifferentiated state of stem cells using a culture supernatant of stem cells. Also found is BC2LCN lectin or a modified product thereof capable of sensitively recognizing the “undifferentiation sugar chain marker” as excellent “probe for detecting the undifferentiation sugar chain marker” capable of determining the undifferentiation status of cells using a culture supernatant.Type: ApplicationFiled: October 31, 2012Publication date: July 23, 2015Inventors: Hiroaki Tateno, Jun Hirabayashi, Yuzuru Ito, Yasuko Onuma, Makoto Asashima, Atsushi Kuno, Masaki Warashina, Masakazu Fukuda
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Patent number: 9075196Abstract: An optical fiber jacket remover draws a glass fiber out from a coating by cutting the coating in a jacket removing portion and moving an optical fiber holding portion away from a jacket remover main unit in a heated state. The jacket removing portion is provided with a heater supporting member on which a heater is mounted. The heater supporting member is accommodated in a recessed receiving portion formed in a case. A heat insulating space is formed between the recessed receiving portion and the heater supporting member. A side surface of the heater supporting member and an inside surface of a lateral wall of the recessed receiving portion are brought into contact with each other via a lateral rib formed on the heater supporting member, and the heat insulating space is thereby blocked.Type: GrantFiled: November 22, 2010Date of Patent: July 7, 2015Assignees: SUMITOMO ELECTRIC INDUSTRIES, LTD., SEI Optifrontier Co., Ltd.Inventors: Toshihiko Homma, Masakazu Fukuda, Kiyoshi Nakazawa, Masahiro Hasegawa
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Publication number: 20150168649Abstract: A heating device for heating an optical fiber reinforcing member includes fiber holders to hold optical fibers covered with the reinforcing member at a fusion-spliced portion, a heater to heat the reinforcing member, a power supply unit to apply a voltage to the heater, and a controller to control the application of a voltage from the power supply unit to the heater. The controller includes a detecting unit that detects a parameter for determining the amount of heat generation of the heater, a storage unit that stores a plurality of heating conditions that vary depending on the parameter value, and a condition instruction unit that selects any of the plurality of heating conditions in accordance with the parameter value detected by the detecting unit and instructs the power supply unit to apply a voltage to the heater on the basis of the selected heating condition.Type: ApplicationFiled: July 25, 2013Publication date: June 18, 2015Applicant: SEI OPTIFRONTIER CO., LTD.Inventors: Masakazu Fukuda, Kensuke Ito
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Publication number: 20150111218Abstract: Provided are a method for accurately evaluating the differentiation status of stem cells by selectively staining only stem cells in an undifferentiated state, and a method for positively isolating only stem cells in an undifferentiated state. Specifically provided is a method for determining differentiation of a cell comprising a step of contacting a test cell with a probe comprising protein (A) or (B) below and a step of detecting the presence of binding of the probe to the test cell. The method for determining differentiation of a cell is capable of detecting the presence or absence of an undifferentiated stem cell in test cells by using a probe that specifically reacts with undifferentiated stem cells and detecting the presence of bonding to the test cell.Type: ApplicationFiled: February 27, 2013Publication date: April 23, 2015Applicants: National Institute of Advanced Industrial Science and Technology, Wako Pure Chemical Industries, Ltd.Inventors: Hiroaki Tateno, Jun Hirabayashi, Makoto Asashima, Yuzuru Ito, Yasuko Onuma, Masaki Warashina, Masakazu Fukuda
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Patent number: 8992101Abstract: An optical fiber reinforcing heating device has a base part, to which a first lid part for covering a sleeve accommodation groove for containing a fiber reinforcement sleeve covering a fusion-splicing part of optical fibers is attached so as to be openable and closable. A pair of fiber holders for holding and securing the optical fibers are disposed on both end sides of the first lid part. Each fiber holder has a second lid part which is attached to a fiber container so as to be openable and closable and presses the optical fiber against the fiber container. A switch lever which is movable longitudinally of the sleeve accommodation groove is disposed on the upper face of the second lid part built in with a pin adapted to move in conjunction with the switch lever. A joint hole adapted to engage the pin is formed within the first lid part.Type: GrantFiled: December 19, 2011Date of Patent: March 31, 2015Assignee: SEI Optifrontier Co., Ltd.Inventors: Masakazu Fukuda, Ryuichiro Sato, Hisao Yui, Hiroshi Takayanagi