Abstract: An antibody-drug conjugate represented by formula (I): (where Ab is an antibody, X is a group represented by formula (X-1), formula (X-2) or formula (X-3): (where at the left represents the binding site with NH and at the right represents the binding side with D), D is a group represented by formula (D-1) or formula (D-2): (where represents the binding site with X), and n is in the range of about 1 to about 8).

Abstract: An object of the present invention is to provide a novel agent for adjusting hardness of a lens of an eye which can be taken easily, conveniently, and safely for a long-term, can effectively adjust the hardness of the lens, and is capable of preventing, alleviating and improving poor focus and decreased near visual acuity, such as presbyopia, caused by aging and various diseases. The present invention solves the above object by providing an agent for adjusting hardness of a lens of an eye comprising a glycosyl hesperetin as an active ingredient.

Abstract: The fluid feeding system includes a feed channel connected to the discharging device, a pump connected to the feed channel, a valve for blocking a flow of the fluid that flows toward the introduction chamber via the feed channel, and a control device for determining a pressure state on the pump side and carrying out an opening-and-closing control of the valve 70 based on the determination result. The control device carries out the opening-and-closing control in which the valve is made into an open state when the control device determines that a pressure P1 on the pump side reaches a pressure state exceeding a given pressure.

Abstract: The purpose is to provide a fluid feeding system which can feed fluid so that an internal pressure fluctuation of an introduction chamber provided to a discharging device is minimized to minimize a poor discharge of the fluid, and to provide a molding system provided with the fluid feeding system. The fluid feeding system 50 includes a feed channel 60 connected to the discharging device 20, a pump 80 connected to the feed channel 60, a valve 70 for blocking a flow of the fluid that flows toward the introduction chamber 28 via the feed channel 60, and a control device 100 for determining a pressure state on the pump 80 side and carrying out an opening-and-closing control of the valve 70 based on the determination result. The control device 100 carries out the opening-and-closing control in which the valve 70 is made into an open state when the control device 100 determines that a pressure P1 on the pump 80 side reaches a pressure state exceeding a given pressure.