Patents by Inventor Masaki Setoguchi

Masaki Setoguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DISPIROPYRROLIDINE DERIVATIVES
    Publication number: 20220106324
    Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
    Type: Application
    Filed: April 19, 2021
    Publication date: April 7, 2022
    Inventors: Yuuichi SUGIMOTO, Kouichi UOTO, Takanori WAKABAYASHI, Masaki MIYAZAKI, Masaki SETOGUCHI, Toru TANIGUCHI, Keisuke YOSHIDA, Akitake YAMAGUCHI, Shoko YOSHIDA
  • DISPIROPYRROLIDINE DERIVATIVES
    Publication number: 20140121196
    Abstract: A compound that inhibits interaction between, murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
    Type: Application
    Filed: November 14, 2013
    Publication date: May 1, 2014
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Yuuichi Sugimoto, Kouichi Uoto, Takanori Wakabayashi, Masaki Miyazaki, Masaki Setoguchi, Toru Taniguchi, Keisuke Yoshida, Akitake Yamaguchi, Shoko Yoshida
  • Dispiropyrrolidine derivatives
    Patent number: 8629133
    Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: January 14, 2014
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Yuuichi Sugimoto, Kouichi Uoto, Takanori Wakabayashi, Masaki Miyazaki, Masaki Setoguchi, Toru Taniguchi, Keisuke Yoshida, Akitake Yamaguchi, Shoko Yoshida
  • DISPIROPYRROLIDINE DERIVATIVES
    Publication number: 20130165424
    Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
    Type: Application
    Filed: March 9, 2012
    Publication date: June 27, 2013
    Inventors: Yuuichi Sugimoto, Kouichi Uoto, Takanori Wakabayashi, Masaki Miyazaki, Masaki Setoguchi, Toru Taniguchi, Keisuke Yoshida, Akitake Yamaguchi, Shoko Yoshida
  • Morpholinopurine derivatives
    Patent number: 8309546
    Abstract: There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: November 13, 2012
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Kiyoshi Nakayama, Kazuyuki Sugita, Masaki Setoguchi, Yuichi Tominaga, Masanori Saitou, Takashi Odagiri
  • DISPIROPYRROLIDINE DERIVATIVES
    Publication number: 20120264738
    Abstract: A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
    Type: Application
    Filed: March 9, 2012
    Publication date: October 18, 2012
    Inventors: Yuuichi Sugimoto, Kouichi Uoto, Takanori Wakabayashi, Masaki Miyazaki, Masaki Setoguchi, Toru Taniguchi, Keisuke Yoshida, Akitake Yamaguchi, Shoko Yoshida
  • MORPHOLINOPURINE DERIVATIVES
    Publication number: 20120071476
    Abstract: There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.
    Type: Application
    Filed: November 30, 2011
    Publication date: March 22, 2012
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Kiyoshi Nakayama, Kazuyuki Sugita, Masaki Setoguchi, Yuichi Tominaga, Masanori Saitou, Takashi Odagiri
  • Morpholinopurine derivatives
    Patent number: 8097622
    Abstract: There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: January 17, 2012
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Kiyoshi Nakayama, Kazuyuki Sugita, Masaki Setoguchi, Yuichi Tominaga, Masanori Saitou, Takashi Odagiri
  • MORPHOLINOPURINE DERIVATIVES
    Publication number: 20100130492
    Abstract: There is provided a novel compound that inhibits phosphatidylinositol 3-kinase (PI3K) and/or the mammalian target of rapamycin (mTOR) and exhibits anti-tumor activity. The present invention provides a compound represented by the following formula (1) having various substituents that inhibits PI3K and/or mTOR and exhibits anti-tumor activity: wherein R1, R2, R3, R4, Ra, Rb, Rc, and X each have the same meaning as defined in the specification.
    Type: Application
    Filed: October 14, 2009
    Publication date: May 27, 2010
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Kiyoshi Nakayama, Kazuyuki Sugita, Masaki Setoguchi, Yuichi Tominaga, Masanori Saitou, Takashi Odagiri
  • Process for producing pyrrolidine derivative
    Patent number: 7345179
    Abstract: This invention provides an industrially useful process for producing 1,4-transcyclohexanecarboxylic acid derivative (1) which has excellent VLA-4 inhibitory action and safety, and an intermediate which is useful in such method.
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: March 18, 2008
    Assignee: Daiichi Pharmaceutical Co., Ltd.
    Inventors: Atsushi Nakayama, Nobuo Machinaga, Yoshiyuki Yoneda, Masaki Setoguchi
  • Process for producing pyrrolidine derivative
    Publication number: 20070105935
    Abstract: This invention provides an industrially useful process for producing 1,4-transcyclohexanecarboxylic acid derivative (1) which has excellent VLA-4 inhibitory action and safety, and an intermediate which is useful in such method.
    Type: Application
    Filed: May 7, 2004
    Publication date: May 10, 2007
    Applicant: DAIICHI PHARMACEUTICAL CO., LTD.
    Inventors: Atsushi Nakayama, Nobuo Machinaga, Yoshiyuki Yoneda, Masaki Setoguchi