Patents by Inventor Masakiyo Inoue
Masakiyo Inoue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240124571Abstract: Provided is a substance capable of effectively suppressing cancer metastasis or a pharmaceutical composition that effectively acts on an inflammatory disease. The pharmaceutical composition is a pharmaceutical composition containing, as an active ingredient, an antibody or an antibody fragment thereof having antigen-binding activity for an S100A8/A9 heterodimer, and blocks interaction between S100A8/A9 and a group of receptors therefor, to thereby strongly suppress cancer metastasis both in vitro and in vivo, or alleviate inflammation. That is, the anti-S100A8/A9 antibody or the antibody fragment thereof can strongly suppress cancer metastasis or alleviate inflammation, by virtue of its blocking action on the interaction between S100A8/A9 and the group of receptors therefor.Type: ApplicationFiled: November 17, 2023Publication date: April 18, 2024Applicant: National University Corporation Okayama UniversityInventors: Masakiyo SAKAGUCHI, Shinichi TOYOOKA, Shuta TOMIDA, Kazuhiko SHIEN, Hiroki SATO, Rie KINOSHITA, Junichiro FUTAMI, Kota ARAKI, Mikio OKAZAKI, Eisaku KONDO, Yusuke INOUE, Akira YAMAUCHI
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Patent number: 7883330Abstract: A powder compression molding machine is configured such that a plurality of lower and upper punches 61, 41 are allowed to enter a plurality of through-die holes 31 provided in first and second molding die sections 32, 33 of a slide plate 3 in a compression molding zone 21 to compressively mold powder and the slide plate 3 is slid to push out compacts downward and collect them in compact discharge zones 22a, 22b. Even when powder is compressively molded at a low compression force into solids having high porosity, compacts can satisfactorily be molded and collected without crumblingness, the compacts having sufficient high porosity and being dissolvable in water or the like.Type: GrantFiled: May 15, 2007Date of Patent: February 8, 2011Assignees: Qualicaps Co., Ltd., Meiji Dairies CorporationInventors: Masakiyo Inoue, Mitsuho Shibata, Ikuru Toyoda, Shoushi Tsukamoto
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Publication number: 20090130243Abstract: A powder compression molding machine is configured such that a plurality of lower and upper punches 61, 41 are allowed to enter a plurality of through-die holes 31 provided in first and second molding die sections 32, 33 of a slide plate 3 in a compression molding zone 21 to compressively mold powder and the slide plate 3 is slid to push out compacts downward and collect them in compact discharge zones 22a, 22b. Even when powder is compressively molded at a low compression force into solids having high porosity, compacts can satisfactorily be molded and collected without crumblingness, the compacts having sufficient high porosity and being dissolvable in water or the like.Type: ApplicationFiled: May 15, 2007Publication date: May 21, 2009Inventors: Masakiyo Inoue, Mitsuho Shibata, Ikuru Toyoda, Shoushi Tsukamoto
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Patent number: 6877611Abstract: A weight selecting apparatus capable of automatically performing calibration, and providing a weight selecting apparatus capable of certainly carrying objects to be inspected with a relatively simple mechanism and performing weight measurement of the objects. The objects, after being subjected to weight measurement by a first weighing unit 2, are sampled by a sampler 5, and those of the objects thus sampled are subjected to weight measurement by a second weighing unit 6. A calibration unit compares, for the same object, the measured result with that obtained by the first weighing unit 2 and discriminates whether or not a difference therebetween is within a specific error range, to perform calibration of the first weighing unit 2. Further, as a carrier 3 for carrying the objects to the weighing unit 2 one by one uses an intermittently rotatable carrying roller 32 having in its outer peripheral surface portion a plurality of carrying pockets 321.Type: GrantFiled: September 25, 2002Date of Patent: April 12, 2005Assignee: Shionogi Qualicaps Co., Ltd.Inventors: Taizo Yamamoto, Masakiyo Inoue, Yoshihisa Kawaguchi
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Publication number: 20030019797Abstract: The invention provides a weight selecting apparatus capable of automatically performing calibration, and provides a weight selecting apparatus capable of certainly carrying objects to be inspected with a relatively simple mechanism and performing weight measurement of the objects. The objects, after being subjected to weight measurement by a first weighing unit 2, are sampled by a sampler 5, and those of the objects thus sampled are subjected to weight measurement by a second weighing unit 6. A calibration unit compares, for the same object, the measured result with that obtained by the first weighing unit 2 and discriminates whether or not a difference therebetween is within a specific error range, to perform calibration of the first weighing unit 2. Further, as a carrier 3 for carrying the objects to the weighing unit 2 one by one, there is used an intermittently rotatable carrying roller 32 having in its outer peripheral surface portion a plurality of carrying pockets 321.Type: ApplicationFiled: September 25, 2002Publication date: January 30, 2003Applicant: Shionogi Qualicaps Co., Ltd.Inventors: Taizo Yamamoto, Masakiyo Inoue, Yoshihisa Kawaguchi
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Patent number: 6478162Abstract: The invention provides a weight selecting apparatus capable of automatically performing calibration, and provides a weight selecting apparatus capable of certainly carrying objects to be inspected with a relatively simple mechanism and performing weight measurement of the objects. The objects, after being subjected to weight measurement by a first weighing unit 2, are sampled by a sampler 5, and those of the objects thus sampled are subjected to weight measurement by a second weighing unit 6. A calibration unit compares, for the same object, the measured result with that obtained by the first weighing unit 2 and discriminates whether or not a difference therebetween is within a specific error range, to perform calibration of the first weighing unit 2. Further, as a carrier 3 for carrying the objects to the weighing unit 2 one by one, there is used an intermittently rotatable carrying roller 32 having in its outer peripheral surface portion a plurality of carrying pockets 321.Type: GrantFiled: March 9, 2000Date of Patent: November 12, 2002Assignee: Shionogi Qualicaps Co., Ltd.Inventors: Taizo Yamamoto, Masakiyo Inoue, Yoshihisa Kawaguchi
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Patent number: 5209040Abstract: A capsule sealing apparatus is provided which includes a capsule supplying device, a slat, a capsule conveyor unit, a capsule sealing device, a plurality of capsule retaining plates, a drying device, and a capsule discharging device. The capsule supplying device intermittently supplies a prescribed number of capsules at a time. The slat includes a plurality of capsule resting slits for individually accommodating the capsules. The capsule conveyor unit linearly reciprocates the slat, during which the capsules are individually accommodated in respective capsule resting slits. The capsule sealing device coats the seams of the capsules with a sealing liquid through the openings at the bottoms of the slits in the slat. The capsule retaining plates receives all the capsules thereon. The drying device vertically circulates the capsule retaining plate with the charged capsules thereon in the horizontal posture so as to dry the sealing liquid applied on each capsule.Type: GrantFiled: July 16, 1992Date of Patent: May 11, 1993Assignee: Nippon Elanco Kabushiki KaishaInventors: Taizo Yamamoto, Masakiyo Inoue, Yoshihisa Kawaguchi
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Patent number: 4959943Abstract: A capsule charging apparatus that is a capsule conveying device disposed on a stand internally provided with at least one driving unit and a capsule charging device including at least one charging unit disposed on a stand which is detachably attached to the side of the stand of said capsule conveying device, said capsule conveying device arranging a plurality of capsules in which body portion are fitted into cap portions substantially vertically with their cap portions uppermost and their body portions below the cap portions; separating the capsules into the cap portions and the body portions; moving the separated cap portions and body portions in the horizontal direction; and fitting together the body portions and the cap portions again and said charging unit being driven by the driving unit inside the stand of said capsule conveying device.Type: GrantFiled: March 10, 1989Date of Patent: October 2, 1990Assignee: Nippon Elanco Kabushiki KaishaInventors: Taizo Yamamoto, Masakiyo Inoue