Patents by Inventor Masami Todokoro
Masami Todokoro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11131654Abstract: A column mainly comprises a tube, a plug, a first filter, a second filter, a stopper, and a connector. The tube mainly comprises a bottomed cylindrical storage part, and a cylindrical bottom-side connection part connected to a bottom of the storage part. The storage part and the bottom-side connection part are coaxially provided. The plug mainly comprises an outer pipe coaxially provided, and an inner pipe provided on an inner side of the outer pipe. The first filter and the second filter each are such a filter as not to enable the filler to pass. The stopper mainly comprises a stopper gripping part, and a stopper insertion part. The connector mainly comprises a connector gripping part and a connector insertion part.Type: GrantFiled: August 1, 2017Date of Patent: September 28, 2021Assignee: JNC CORPORATIONInventor: Masami Todokoro
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Patent number: 11097208Abstract: A vise for column, for attaching a plug to a column tube of a column for chromatography comprising the column tube and the plug to be attached to one end of the column tube, is provided. The vise comprises a column supporter configured to be able to support a part of the column for chromatography, a main body configured to be connected to the column supporter and extending from the column supporter by a predetermined distance, and a column presser configured to be supported at another end of the main body opposite to one end to which the column supporter is connected, and configured to be movable toward and away from the column supporter, and configured to be able to press the plug against the column tube.Type: GrantFiled: March 6, 2019Date of Patent: August 24, 2021Assignee: JNC CORPORATIONInventors: Naoki Yamanaka, Masami Todokoro
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Patent number: 11058970Abstract: A vise for column, for attaching a plug to a column tube of a column for chromatography comprising the column tube and the plug to be attached to one end of the column tube, is provided. The vise comprises a column supporter configured to be able to support a part of the column for chromatography, a main body configured to be connected to the column supporter and extending from the column supporter by a predetermined distance, and a column presser configured to be supported at another end of the main body opposite to one end to which the column supporter is connected, and configured to be movable toward and away from the column supporter, and configured to be able to press the plug against the column tube.Type: GrantFiled: March 6, 2019Date of Patent: July 13, 2021Assignee: JNC CORPORATIONInventors: Naoki Yamanaka, Masami Todokoro
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Publication number: 20190374875Abstract: A column filling apparatus mainly includes a tank, a stirrer being an agitator, a pump, a resin bottle, first to eleventh pipes, first to fourth valves composed of three-way valves, and fifth and sixth valves composed of two-way valves. A suction port is mounted on a leading end of the fifth pipe, and the suction port is inserted into an inner part from a top opening of the resin bottle. The other end of the fifth pipe is connected to the first valve. The first valve is connected to the first pipe, the second pipe, and the fifth pipe, and connects or disconnects these pipes to or from each other. An end of the first pipe is mounted near a bottom of the tank, and is opened near an inner bottom surface of the tank.Type: ApplicationFiled: June 6, 2019Publication date: December 12, 2019Applicant: JNC CORPORATIONInventors: Naoki YAMANAKA, Masami TODOKORO
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Publication number: 20190275445Abstract: A vise for column, for attaching a plug to a column tube of a column for chromatography comprising the column tube and the plug to be attached to one end of the column tube, is provided. The vise comprises a column supporter configured to be able to support a part of the column for chromatography, a main body configured to be connected to the column supporter and extending from the column supporter by a predetermined distance, and a column presser configured to be supported at another end of the main body opposite to one end to which the column supporter is connected, and configured to be movable toward and away from the column supporter, and configured to be able to press the plug against the column tube.Type: ApplicationFiled: March 6, 2019Publication date: September 12, 2019Applicant: JNC CORPORATIONInventors: Naoki YAMANAKA, Masami TODOKORO
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Publication number: 20190250129Abstract: A column mainly comprises a tube, a plug, a first filter, a second filter, a stopper, and a connector. The tube mainly comprises a bottomed cylindrical storage part, and a cylindrical bottom-side connection part connected to a bottom of the storage part. The storage part and the bottom-side connection part are coaxially provided. The plug mainly comprises an outer pipe coaxially provided, and an inner pipe provided on an inner side of the outer pipe. The first filter and the second filter each are such a filter as not to enable the filler to pass. The stopper mainly comprises a stopper gripping part, and a stopper insertion part. The connector mainly comprises a connector gripping part and a connector insertion part.Type: ApplicationFiled: August 1, 2017Publication date: August 15, 2019Applicant: JNC CORPORATIONInventor: Masami TODOKORO
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Patent number: 10155217Abstract: A means for selectively removing ET under coexistence of a substance showing a negative charge, such as nucleic acid is described. Endotoxin is selectively removed by bringing a polymer obtained by crosslinking cyclodextrin with an isocyanate-based crosslinking agent in contact with a solution containing endotoxin and the substance showing the negative charge such as nucleic acid.Type: GrantFiled: October 4, 2016Date of Patent: December 18, 2018Assignees: NATIONAL UNIVERSITY CORPORATION KUMAMOTO, JNC CORPORATIONInventors: Masayo Sakata, Masami Todokoro
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Publication number: 20170021332Abstract: A means for selectively removing ET under coexistence of a substance showing a negative charge, such as nucleic acid is described. Endotoxin is selectively removed by bringing a polymer obtained by crosslinking cyclodextrin with an isocyanate-based crosslinking agent in contact with a solution containing endotoxin and the substance showing the negative charge such as nucleic acid.Type: ApplicationFiled: October 4, 2016Publication date: January 26, 2017Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, JNC CORPORATIONInventors: MASAYO SAKATA, MASAMI TODOKORO
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Patent number: 9505850Abstract: A means for selectively removing ET under coexistence of a substance showing a negative charge, such as nucleic acid is described. Endotoxin is selectively removed by bringing a polymer obtained by crosslinking cyclodextrin with an isocyanate-based crosslinking agent in contact with a solution containing endotoxin and the substance showing the negative charge such as nucleic acid.Type: GrantFiled: May 29, 2013Date of Patent: November 29, 2016Assignees: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, JNC CORPORATIONInventors: Masayo Sakata, Masami Todokoro
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Patent number: 9446382Abstract: The present invention provides a porous cellulose gel having a high mechanical strength capable of being operated at a higher flow rate, and a method for producing the same. To a suspension liquid of cellulose particles, a crosslinking agent in an amount of from 4 to 12 times the amount of the cellulose monomer in terms of moles and an alkali in an amount of from 0.1 to 1.5 times the amount of the crosslinking agent in terms of moles are added continuously dropwise or added dividedly over a prescribed period of time, whereby flow rate characteristics of a resulting porous cellulose gel can be enhanced. According to the invention, the production efficiency of a polymer substance, such as a nucleic acid and a protein can be enhanced.Type: GrantFiled: January 14, 2014Date of Patent: September 20, 2016Assignee: JNC CORPORATIONInventors: Yasuto Umeda, Yasuo Matsumoto, Masami Shiina, Masami Todokoro, Yoshihiro Matsumoto
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Patent number: 9327050Abstract: A hemostatic material as a high-performance medical material is described, which is capable of stopping bleeding in short time and is easy to handle and produce. The hemostatic material contains a nano-fiber that contains: a polymer, and a polypeptide having a peptide fragment represented by formula (1): -(Pro-Y-Gly)n-??(1) wherein Y represents hydroxyproline or proline, and n represents an integer ranging from 5 to 9000.Type: GrantFiled: March 22, 2013Date of Patent: May 3, 2016Assignee: JNC CORPORATIONInventors: Hisatoshi Kobayashi, Dohiko Terada, Masami Todokoro, Akiko Shimatani, Yukinori Kataoka
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Publication number: 20150112050Abstract: A means for selectively removing ET under coexistence of a substance showing a negative charge, such as nucleic acid is described. Endotoxin is selectively removed by bringing a polymer obtained by crosslinking cyclodextrin with an isocyanate-based crosslinking agent in contact with a solution containing endotoxin and the substance showing the negative charge such as nucleic acid.Type: ApplicationFiled: May 29, 2013Publication date: April 23, 2015Inventors: Masayo Sakata, Masami Todokoro
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Patent number: 8912117Abstract: The present invention provides a chromatography packing material having improved flow rate characteristics and adsorption characteristics. In particular, the present invention provides a chromatography packing material suitable for separation and purification of immunoglobulin in the manufacture of antibody preparations. A porous cellulose gel, which is made by adding polysaccharides having a limiting viscosity of 0.21 to 0.90 dL/g to porous cellulose particles, the dry weight per unit volume of the porous cellulose gel being 1.06 to 1.40 times the dry weight per unit volume of the porous cellulose particles, is used. By adding a predetermined amount of polysaccharides having a predetermined limiting viscosity to porous cellulose particles, flow rate characteristics and adsorption characteristics can be improved.Type: GrantFiled: February 18, 2010Date of Patent: December 16, 2014Assignee: JNC CorporationInventors: Yoshihiro Matsumoto, Yasuto Umeda, Shigeyuki Aoyama, Masami Todokoro
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Publication number: 20140311984Abstract: A problem is to provide a monolithic structure that is a porous body formed of a polysaccharide being a naturally-occurring polymer, and has continuous pores having an average pore diameter suitable for biomolecule separation to allow formation into an arbitrary shape, and a manufacturing method therefor. A solution is to manufacture the polysaccharide monolithic structure by a method including a first step for dissolving a polysaccharide into a mixed solvent including a solvent into which the polysaccharide is soluble and a solvent into which the polysaccharide is insoluble, at a temperature lower than a boiling point of the mixed solvent, to give a polysaccharide solution, and a second step for cooling the polysaccharide solution to give the polysaccharide monolithic structure. The polysaccharide monolithic structure obtained is a porous body having continuous pores having an average pore diameter of 0.01 to 20 micrometers and a thickness of 100 micrometers or more.Type: ApplicationFiled: April 22, 2014Publication date: October 23, 2014Applicant: JNC CORPORATIONInventors: Tsuyoshi NAKAMA, Masami TODOKORO, Eri IWAMOTO
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Patent number: 8735352Abstract: An objective of the invention is to provide an adsorbent allowing purification of a blood coagulation factor or a cell adhesion factor under mild conditions, according to simple procedures, and at a low cost and safely while having a high affinity and a high resistance to deterioration, and a method for purifying the blood coagulation factor or the cell adhesion factor; a solution is to apply a polypeptide having peptide fragments represented by formula (1) as the adsorbent for the blood coagulation factor or the cell adhesion factor, and to purify the blood coagulation factor or the cell adhesion factor using the adsorbent: -(Pro-Hyp-Gly)n- Wherein, in formula (1), n is an integer from 2 to 9,000.Type: GrantFiled: December 5, 2012Date of Patent: May 27, 2014Assignee: JNC CorporationInventors: Masami Todokoro, Akiko Shimatani
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Publication number: 20140128253Abstract: The present invention provides a porous cellulose gel having a high mechanical strength capable of being operated at a higher flow rate, and a method for producing the same. To a suspension liquid of cellulose particles, a crosslinking agent in an amount of from 4 to 12 times the amount of the cellulose monomer in terms of moles and an alkali in an amount of from 0.1 to 1.5 times the amount of the crosslinking agent in terms of moles are added continuously dropwise or added dividedly over a prescribed period of time, whereby flow rate characteristics of a resulting porous cellulose gel can be enhanced. According to the invention, the production efficiency of a polymer substance, such as a nucleic acid and a protein can be enhanced.Type: ApplicationFiled: January 14, 2014Publication date: May 8, 2014Applicant: JNC CORPORATIONInventors: Yasuto UMEDA, Yasuo MATSUMOTO, Masami SHIINA, Masami TODOKORO, Yoshihiro MATSUMOTO
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Patent number: 8664152Abstract: The present invention provides a porous cellulose gel having a high mechanical strength capable of being operated at a higher flow rate, and a method for producing the same. To a suspension liquid of cellulose particles, a crosslinking agent in an amount of from 4 to 12 times the amount of the cellulose monomer in terms of moles and an alkali in an amount of from 0.1 to 1.5 times the amount of the crosslinking agent in terms of moles are added continuously dropwise or added dividedly over a prescribed period of time, whereby flow rate characteristics of a resulting porous cellulose gel can be enhanced. According to the invention, the production efficiency of a polymer substance, such as a nucleic acid and a protein can be enhanced.Type: GrantFiled: August 27, 2008Date of Patent: March 4, 2014Assignee: JNC CorporationInventors: Yasuto Umeda, Yasuo Matsumoto, Masami Shiina, Masami Todokoro, Yoshihiro Matsumoto
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Publication number: 20130253099Abstract: With respect to synthetic collagen that has so far been difficult to be nano-fiberized, a method for producing uniform and long fibrous nano-fibers containing a synthetic collagen is described. The nano-fibers contain a polypeptide having a peptide fragment represented by Formula (1): -(Pro-Y-Gly)n??(1), wherein Y represents hydroxyproline or proline, and n is an integar ranging from 5 to 9000. The producing method includes a step of preparing a spinning solution containing the polypeptide and a polymer, and a step of spinning with an electrospinning method using the spinning solution.Type: ApplicationFiled: March 22, 2013Publication date: September 26, 2013Applicant: JNC CORPORATIONInventors: HISATOSHI KOBAYASHI, DOHIKO TERADA, MASAMI TODOKORO, AKIKO SHIMATANI, YUKINORI KATAOKA
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Publication number: 20130251780Abstract: A hemostatic material as a high-performance medical material is described, which is capable of stopping bleeding in short time and is easy to handle and produce. The hemostatic material contains a nano-fiber that contains: a polymer, and a polypeptide having a peptide fragment represented by formula (1): -(Pro-Y-Gly)n- ??(1) wherein Y represents hydroxyproline or proline, and n represents an integer ranging from 5 to 9000.Type: ApplicationFiled: March 22, 2013Publication date: September 26, 2013Applicant: JNC CORPORATIONInventors: HISATOSHI KOBAYASHI, DOHIKO TERADA, MASAMI TODOKORO, AKIKO SHIMATANI, YUKINORI KATAOKA
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Patent number: 8445427Abstract: The invention provides a method for selecting and eliminating endotoxin selectively from a solution where a highly acidic substance such as heparin co-exists, and an adsorbent used therefore. The invention also provides a method for providing the endotoxin adsorbent, which includes partially modifying amino groups contained within an amino group-containing molecule used as a ligand of the endotoxin adsorbent, with a molecule that is capable of reacting with an amino group.Type: GrantFiled: November 22, 2006Date of Patent: May 21, 2013Assignee: JNC CorporationInventors: Minoru Nakayama, Masami Todokoro