Patents by Inventor Masamitsu Hoshikawa

Masamitsu Hoshikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8569058
    Abstract: A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: October 29, 2013
    Assignee: ONO Pharmaceutical Co., Ltd.
    Inventors: Narito Tateishi, Junki Yamamoto, Soichi Kawaharada, Tsutomu Akiyama, Masamitsu Hoshikawa
  • Patent number: 7579375
    Abstract: The present invention relates to a compound represented by formula (I) wherein R1 represents optionally protected hydroxy or oxo, indicates ?-configuration, ?-configuration or a mixture of these in an arbitrary proportion, n represents an integer of 1 to 3, and m represents 0 or an integer of 1 to 10; and wherein two or more R1's are not bound to the same carbon atom other than the terminal carbon atom, a salt thereof or a prodrug thereof. The compounds represented by formula (I) have an ability to improve astrocyte function, and they are useful as a preventive and/or therapeutic agent for a brain infarction, neuronal dysfunction by brain infarction, Parkinson's disease, Parkinson's syndrome, amyotrophic lateral sclerosis or Alzheimer's disease.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: August 25, 2009
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Haruo Imawaka, Tomoyuki Hasegawa, Shigeru Sakuyama, Yasufumi Kawanaka, Tsutomu Akiyama, Masamitsu Hoshikawa, Saiko Matsuda
  • Publication number: 20070167522
    Abstract: The present invention relates to a compound represented by formula (I) wherein R1 represents optionally protected hydroxy or oxo, indicates ?-configuration, ?-configuration or a mixture of these in an arbitary proportion, n represents an integer of 1 to 3, and m represents 0 or an integer of 1 to 10; and wherein two or more R1's are not bound to the same carbon atom other than the terminal carbon atom, a salt thereof or a prodrug thereof. The compounds represented by formula (I) have an ability to improve astrocyte function, and they are useful as a preventive and/or therapeutic agent for a brain infarction, neuronal dysfunction by brain infarction, Parkinson's disease, Parkinson's syndrome, amyotrophic lateral sclerosis or Alzheimer's disease.
    Type: Application
    Filed: July 14, 2004
    Publication date: July 19, 2007
    Inventors: Haruo Imawaka, Tomoyuki Hasegawa, Shigeru Sakuyama, Yasufumi Kawanaka, Tsutomu Akiyama, Masamitsu Hoshikawa, Saiko Matsuda
  • Publication number: 20070043114
    Abstract: A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and/or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and/or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and/or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and/or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.
    Type: Application
    Filed: October 1, 2004
    Publication date: February 22, 2007
    Inventors: Narito Tateishi, Junki Yamamoto, Soichi Kawaharada, Tsutomu Akiyama, Masamitsu Hoshikawa