Patents by Inventor Masanobu Nagano
Masanobu Nagano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6099285Abstract: A process and an apparatus for molding, in which a molten thermoplastic resin is firmly fitted onto a molding surface of a mold under a pressure lower than or equal to 100 kg/cm.sup.2 and is cured to obtain a molded product. The molding apparatus has a mold main body, and a mold body on which the molding surface is defined. The mold body is supported relative to the mold main body with maintaining a space on the back side of the molding surface in a heat insulative manner by a supporting member which includes at least a heat insulative supporting member having a thermal conductivity of 0.001 to 1 Kcal/mh .degree.C. and a longitudinal elastic modulus of 0.01 to 10 kg/cm.sup.2. In the space, a heating fluid for heating the molding surface from the bask side to a temperature higher than or equal to Vicat softening temperate (T) .degree.C.Type: GrantFiled: January 6, 1999Date of Patent: August 8, 2000Assignee: Japan Synthetic Rubber Co., Ltd.Inventors: Fumio Kurihara, Mitsuyoshi Kumamoto, Yasuhito Ito, Masanobu Nagano, Jun Nakamura
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Patent number: 6048189Abstract: A process and an apparatus for molding, in which a molten thermoplastic resin is firmly fitted onto a molding surface of a mold under a pressure lower than or equal to 100 kg/cm.sup.2 and is cured to obtain a molded product. The molding apparatus has a mold main body, and a mold body on which the molding surface is defined. The mold body is supported relative to the mold main body with maintaining a space on the back side of the molding surface in a heat insulative manner by a supporting member which includes at least a heat insulative supporting member having a thermal conductivity of 0.001 to 1 Kcal/mh .degree.C. and a longitudinal elastic modulus of 0.01 to 10 kg/cm.sup.2. In the space, a heating fluid for heating the molding surface from the bask side to a temperature higher than or equal to Vicat softening temperate (T) .degree.C.Type: GrantFiled: March 22, 1996Date of Patent: April 11, 2000Assignee: Japan Synthetic Rubber Co., Ltd.Inventors: Fumio Kurihara, Mitsuyoshi Kumamoto, Yasuhito Ito, Masanobu Nagano, Jun Nakamura
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Patent number: 6025375Abstract: Heterocyclic compounds of the formula: ##STR1## whereinR.sup.1 is carboxy or protected carboxy,R.sup.2 is aryl which may have suitable substituent(s),R.sup.3 is aryl which may have suitable substituent(s),A.sup.1 is lower alkylene,A.sup.2 is bond or lower alkylene and-Q- is ##STR2## etc., and pharmaceutically acceptable salts thereof which are useful as a medicament.Type: GrantFiled: June 5, 1998Date of Patent: February 15, 2000Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Masanobu Nagano, Kouji Hattori, Kazunori Tsubaki, Osamu Okitsu, Seiichiro Tabuchi
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Patent number: 5993721Abstract: A process and an apparatus for molding, in which a molten thermoplastic resin is firmly fitted onto a molding surface of a mold under a pressure lower than or equal to 100 kg/cm.sup.2 and is cured to obtain a molded product. The molding apparatus has a mold main body, and a mold body on which the molding surface is defined. The mold body is supported relative to the mold main body with maintaining a space on the back side of the molding surface in a heat insulative manner by a supporting member which includes at least a heat insulative supporting member having a thermal conductivity of 0.001 to 1 Kcal/mh.degree. C. and a longitudinal elastic modulus of 0.01 to 10 kg/cm.sup.2. In the space, a heating fluid for heating the molding surface from the back side to a temperature higher than or equal to Vicat softening temperature (T).degree. C.Type: GrantFiled: September 16, 1997Date of Patent: November 30, 1999Assignee: JSR CorporationInventors: Fumio Kurihara, Mitsuyoshi Kumamoto, Yasuhito Ito, Masanobu Nagano, Jun Nakamura
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Patent number: 5863918Abstract: A compound or the formula: ##STR1## wherein R.sup.1 is carboxy or protected carboxy, R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen, hydroxy, protected hydroxy, etc.,R.sup.4 is hydrogen or halogen,A.sup.1 is lower alkylene,A.sup.2 is bond or lower alkylene,--R.sup.5 is ##STR2## (in which R.sup.6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc., and ##STR3## etc., and a pharmaceutically acceptable salt thereof which are useful as medicaments.Type: GrantFiled: February 23, 1998Date of Patent: January 26, 1999Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Masanobu Nagano, Kouji Hattori, Kazunori Tsubaki, Osamu Okitsu, Seiichiro Tabuchi
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Patent number: 5763489Abstract: A compound of the formula ##STR1## wherein R.sup.1 is carboxy or protected carboxy,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen, hydroxy, protected hydroxy, etc.,R.sup.4 is hydrogen or halogen,A.sup.1 is lower alkylene,A.sup.2 is bond or lower alkylene,--R.sup.5 is ##STR2## (in which R.sup.6 is mono(or di or tri)aryl(lower)alkyl and Z is N or CH), etc., and ##STR3## and a pharmaceutically acceptable salt thereof which are useful as medicaments.Type: GrantFiled: October 10, 1996Date of Patent: June 9, 1998Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Kiyoshi Taniguchi, Masanobu Nagano, Kouji Hattori, Kazunori Tsubaki, Osamu Okitsu, Seiichiro Tabuchi
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Patent number: 5387710Abstract: This invention relates to new ethanolamine derivatives having gut selective sympathomimetic and anti-pollakiuria activities and represented by the general formula [I]: ##STR1## wherein R.sup.1 is aryl or a heterocyclic group, each of which may be substituted with halogen, etc.,R.sup.2 is hydrogen, halogen, nitro, hydroxy, lower alkyl optionally substituted with acyl, lower alkenyl optionally substituted with acyl, lower alkoxy optionally substituted with acyl, or amino optionally substituted with acyl(lower)alkyl,R.sup.3 is hydrogen, an N-protective group, or lower alkyl optionally substituted with lower alkylthio,n is an integer of 0 to 3, anda heavy solid line means a single bond or a double bond,provided that when n is 1, then1) R.sup.1 is a condensed aromatic hydrocarbon group or a heterocyclic group, each of which may be substituted with halogen, etc.Type: GrantFiled: September 17, 1993Date of Patent: February 7, 1995Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Masanobu Nagano, Kiyoshi Taniguchi, Kazuhiko Take, Takeshi Kato, Kazunori Tsubaki
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Patent number: 5216074Abstract: A thermoplastic elastomer composition comprising 99-1 parts by weight of (i) a hydrogenated diene polymer which is a hydrogenation product of a straight or branched chain block copolymer consisting of (C) a polybutadiene block segment having a 1,2-vinyl content of not more than 20% and (D) a block segment which is a polybutadiene or an alkenyl aromatic compound-butadiene copolymer, the butadiene portion of which has a 1,2-vinyl content of 25-95% and 1-99 parts by weight of (ii) at least one of a thermoplastic resin or a rubbery polymer.Type: GrantFiled: July 13, 1990Date of Patent: June 1, 1993Assignee: Japan Synthetic Rubber Co., Ltd.Inventors: Takateru Imai, Masanobu Nagano, Masaaki Mawatari, Toshio Teramoto, Minoru Hasegawa
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Patent number: 5055519Abstract: Thermoplastic elastomer composition characterized by excellent oil resistance while preserving high tear resistance and tension pull resistance comprises non-functionalized block copolymer of aromatic vinyl compound and conjugated diene or selectively hydrogenated product thereof (e.g. styrene-butadiene-styrene block copolymer), rubber polymer having at least one functional group selected from the group consisting of carboxyl, amino, epoxy and hydroxyl (e.g. acrylonitrile-butadiene copolymer containing a carboxyl group as a reactive functional group), and reactive aromatic vinyl polymer having a functional group which is reactive with the functional group of the rubber (e.g. reactive polystyrene containing 1% by weight oxazolinyl group when the rubber polymer is carboxyl group containing acrylonitrile-butadiene copolymer).Type: GrantFiled: August 18, 1989Date of Patent: October 8, 1991Assignee: Shell Internationale Research Maatschappij B.V.Inventors: Hisao Ono, Masanobu Nagano, Yasuo Ieki, Takumi Miyachi
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Patent number: 4987017Abstract: A thermoplastic elastomer composition which comprises 25-95% by weight of a polyamide and 75-5% by weight of a halogenated butyl rubber, a chlorosulfonated polyethylene or both thereof. Said composition is excellent in resistance to Freon gas permeation and has good oil resistance and low-temperature resistance. A hose wherein the layer to be contacted with a gas is made of the above thermoplastic elastomer composition is suitable as a Freon gas R-22 hose.Type: GrantFiled: February 28, 1990Date of Patent: January 22, 1991Assignee: Japan Synthetic Rubber Co., Ltd.Inventors: Hozumi Sato, Humito Shimada, Akio Sakaguchi, Yasuhiko Takemura, Tadaaki Nishi, Hisao Ono, Masanobu Nagano, Takumi Miyachi
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Patent number: 4920129Abstract: The invention relates to an imidazopyridine compound of the following formula: ##STR1## wherein R.sup.1 is lower alkynyl, R.sup.2 is lower alkyl, R.sup.3 is lower alkyl, R.sup.4 is amino or acylamino, R.sup.5 is hydrogen; lower alkyl which may be substituted by halogen, halogen; nitro; amino; acylamino; esterified carboxy; or N,N-di(lower)alkylsufamoyl, and A is lower alkylene, and pharmaceutically acceptable salts thereof, useful in the treatment of ulcers.Type: GrantFiled: September 22, 1988Date of Patent: April 24, 1990Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Youichi Shiokawa, Masanobu Nagano, Hiromichi Itani
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Patent number: 4831041Abstract: The invention relates to an imidazopyridine compound of the formula: ##STR1## wherein R.sup.1 is lower alkynyl, lower alkynyloxy(lower)alkyl or N,N-di(lower)alkylamino(lower)alkynyl,R.sup.2 is lower alkyl,R.sup.3 is mono (or di or tri)-phenyl(lower)alkyl substituted by one or more substituent(s) selected from cyano, carbamoyl, mono (or di or tri(phenyl(lower)alkylamino, acylamino, carboxy, esterified carboxy, hydroxy, hydroxy(lower)alkyl, acyloxy(lower)alkyl, acyloxy, mono (or di or tri)phenyl(lower)alkoxy, lower alkoxy(lower)alkoxy, tetrahydropyranyloxy, and acylamino(lower)alkyl or mono (or di or tri) phenyl(lower)alkyl substituted by lower alkyl and one additional substituent selected from hydroxy(lower)alkyl, amino, N-lower alkyl-N-acylamino, mono (or di or tri)phenyl(lower)alkylamino, acylamino and lower alkylamino, andR.sup.4 is hydrogen or lower alkyl, and a pharmaceutically acceptable salt thereof, useful in the treatment of ulcers.Type: GrantFiled: November 12, 1987Date of Patent: May 16, 1989Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Youichi Shiokawa, Masanobu Nagano, Hiromichi Itani
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Patent number: 4564621Abstract: New .alpha.-aryl-.alpha.-pyridylalkanoic acid derivatives of the formula: ##STR1## wherein R.sup.1 is cyano or carbamoyl,R.sup.2 is hydrogen or halogen,R.sup.3 is hydrogen or lower alkyl,one of R.sup.4 and R.sup.5 is hydrogen and another is lower alkyl,R.sup.6 is hydrogen or lower alkyl, andR.sup.7 is lower alkyl, orR.sup.6 and R.sup.7 are taken together to form an N-containing saturated heterocyclic group with the adjacent nitrogen atom, in which the heterocyclic group may be substituted with lower alkyl or optionally protected hydroxy(lower)alkyl,provided that R.sup.2 is halogen or R.sup.3 is lower alkyl, when R.sup.1 is cyano and R.sup.6 and R.sup.7 are each lower alkyl, and salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents and spasmolytic agents.Type: GrantFiled: September 23, 1983Date of Patent: January 14, 1986Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masanobu Nagano, Atsushi Akahane
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Patent number: 4563455Abstract: New fused imidazole compounds of the formula: ##STR1## wherein A is lower alkylene,R.sup.1 is hydrogen, lower alkyl, lower alkoxy or halogen,R.sup.2 is hydrogen, lower alkyl, cyclo(lower)alkyl, pyridyl, ar(lower)alkyl which may be substituted with halogen, or aryl which may be substituted with lower alkyl, lower alkoxy, hydroxy or halogen,R.sup.3 is N-containing unsaturated heterocyclic group which may be substituted with lower alkyl or amino, andY is .dbd.C-- or .dbd.N--,and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as antiulcer agents.Type: GrantFiled: March 9, 1984Date of Patent: January 7, 1986Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masayuki Kato, Masanobu Nagano, Atsushi Akahane
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Patent number: 4543356Abstract: This invention is directed to new quinazoline derivatives of the following formula having use in the treatment of symptoms associated with allergic manifestations. ##STR1## wherein R.sub.a.sup.1 and R.sub.b.sup.1 are C.sub.2 -C.sub.7 alkoxycarbonyl or R.sub.a.sup.1 and R.sub.b.sup.1 is linked together to form a group of the formula: ##STR2## R.sup.2 and R.sup.3 are hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro, amino, C.sub.1 -C.sub.6 alkoxy, phenoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylpiperazinyl, C.sub.1 -C.sub.18 alkanoylamino, di(C.sub.1 -C.sub.6)alkanoylamino, C.sub.3 -C.sub.9 alkoxalylamino, C.sub.4 -C.sub.8 cycloalkylcarbonylamino, C.sub.3 -C.sub.7 cycloalkyl(C.sub.1 -C.sub.6)alkanoylamino, benzamido, phenyl(C.sub.1 -C.sub.6)alkanoylamino, C.sub.1 -C.sub.6 alkylsulfonylamino or di(C.sub.1 -C.sub.6)alkylamino which may be substituted with hydroxy,A.sup.1 is a group of the formula: ##STR3## in which R.sup.4 is hydrogen C.sub.1 -C.sub.6 alkyl, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.Type: GrantFiled: January 3, 1983Date of Patent: September 24, 1985Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masayuki Kato, Masanobu Nagano
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Patent number: 4429126Abstract: Quinazoline derivatives of the formulae: ##STR1## wherein A.sup.1 is ##STR2## A.sup.2 is ##STR3## R.sup.1 is hydrogen, carboxy or esterified carboxy, R.sub.a.sup.1 and R.sub.b.sup.1 are esterified carboxy,R.sup.2 and R.sup.3 are hydrogen, alkyl, halogen, nitro, amino, alkoxy, aryloxy, alkylthio, alkylpiperazinyl, acylamino or dialkylamino which may be substituted with hydroxy,R.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy, dialkylamino or 2,2-dialkoxycarbonylvinylaminoR.sub.a.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy or dialkylamino,R.sup.5 is alkyl or alkenyl, andR.sup.6 is carboxy or esterified carboxy.Type: GrantFiled: June 4, 1982Date of Patent: January 31, 1984Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masayuki Kato, Masanobu Nagano
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Patent number: 4377580Abstract: Quinazoline derivatives of the formulae: ##STR1## wherein A.sup.1 is ##STR2## A.sup.2 is ##STR3## R.sup.1 is hydrogen, carboxy or esterified carboxy, R.sub.a.sup.1 and R.sub.b.sup.1 are esterified carboxy,R.sup.2 and R.sup.3 are hydrogen, alkyl, halogen, nitro, amino, alkoxy, aryloxy, alkylthio, alkylpiperazinyl, acylamino or dialkylamino which may be substituted with hydroxy,R.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy, dialkylamino or 2,2-dialkoxycarbonylvinylaminoR.sub.a.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy or dialkylamino,R.sup.5 is alkyl or alkenyl, andR.sup.6 is carboxy or esterified carboxy.Type: GrantFiled: November 25, 1980Date of Patent: March 22, 1983Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masayuki Kato, Masanobu Nagano