Patents by Inventor Masanori Kawamura
Masanori Kawamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5164412Abstract: A Derivative of 5-hetero-6-oxo-PGE A derivative of 5-hetero-6-oxo-PGE of the formula: ##STR1## wherein R.sup.1 is (1) a group of the formula: COOR11(2) hydroxymethylcarbonyl,(3) hydroxymethyl or(4) a group of the formula:CO--AAwherein AA is an amino acid-residue,Z is oxygen, sulfur or a group of the formula: NR21 wherein R21 is hydrogen or alkyl of C1--4;R2 is a single-bond or alkylene of C1--4;R3 isi) alkyl of C1-7,ii) cycloalkyl of C4-7 or cycloalkyl of C4-7 substituted by alkyl of C1-7,iii) phenyl, phenoxy, phenyl or phenoxy substituted by one group selected from alkyl of C1-4, halogen and trihalomethyl, is single-bond or a double bond.Possess PG-like activity, especially cytoprotection, and therefore are useful for treatment for and/or prevention of cytodamage.Type: GrantFiled: April 8, 1991Date of Patent: November 17, 1992Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Yoshitaka Konishi, Masanori Kawamura
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Patent number: 5017589Abstract: The compounds of the formula: ##STR1## (wherein R.sup.1 is hydrogen or alkyl; R.sup.2 is carbocyclic or heterocyclic ring, unsubstituted or substituted by R.sup.3 S; R.sup.3 is halogen, trihalomethyl, hydroxy, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfornyl, cyano, nitro, or group of the formula: --C.sub.6 H.sub.4 --R.sup.4, --NR.sup.5 R.sup.6, --CO--R.sup.7, --COOR.sup.8, --CONR.sup.5 R.sup.6, --SO.sub.2 NR.sup.5 R.sup.6 or --NHCO--R.sup.7, in which R.sup.4 is hydrogen, halogen, trihalomethyl, hydroxy, alkyl or alkoxy, R.sup.5 and R.sup.6 are each hydrogen or alkyl, R.sup.7 is alkyl or phenyl substituted by R.sup.4 and R.sup.8 is hydrogen or alkyl; Z is hydrogen or group of the formula: --COR.sup.9, ##STR2## in which R.sup.9 is alkyl or phenyl substituted by R.sup.10, in which R.sup.10 is hydrogen, halogen, trihalomethyl, alkyl or alkoxy, R.sup.11 and R.sup.12 are each hydrogen, alkyl or phenyl substituted by R.sup.10, or R.sup.11 and R.sup.12 together represent alkylene and p is 1 or 2; .circle.Type: GrantFiled: May 5, 1989Date of Patent: May 21, 1991Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Masanori Kawamura, Yoshinobu Arai, Hideki Aishita
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Patent number: 5013734Abstract: The esters of phenylalkanoic acid of the formula: ##STR1## wherein R.sup.1 is 4-10 membered, saturated or unsaturated, mono- or bi-cyclic hetero ring containing as hetero atoms:(i) one or two nitrogen,(ii) two or three of nitrogen and sulfur in total, or(iii) one or two sulfur;R.sup.2 is hydrogen; orR.sup.1 and R.sup.2, taken together with a nitrogen to which they are attached, form 4-7 membered, saturated or unsaturated, mono-cyclic hetero ring containing as hetero atoms:(i) one or two nitrogen, or(ii) two or three of nitrogen and oxygen in total,the aforementioned hetero rings, represented by R.sup.1 or formed by R.sup.1 and R.sup.2, taken together with a nitrogen to which they are attached, may be substituted by one substituent selected from C1-4 alkyl and C2-5 acyl;R.sup.3 each, independently, is hydrogen or C1-4 alkyl;R.sup.4 is hydrogen, halogen, trihalomethyl, C1-4 alkyl, C1-4 alkoxy, C2-5 acyl, cyano, nitro or nitroxy;R.sup.5 each, independently, is hydrogen, C1-4 alkyl or phenyl; or the two R.sup.Type: GrantFiled: May 11, 1990Date of Patent: May 7, 1991Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Sadahiko Iguchi, Masanori Kawamura, Tsumoru Miyamoto
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Patent number: 4967974Abstract: Disclosed is taping equipment for a web feeding device wherein feeding of a web from a web roll is achieved by the free rotation of center blocks, and the web is rewound by rotationally driving the center blocks in the direction opposite to the web delivering direction, comprising a lifter; a roller rotatably supported at one end of a first arm pivotally supported upon a support disposed upon the upper surface of the lifter by means of a shaft, and upon which an adhesive tape delivered from a tape roll removably attached to the shaft is conveyed with the adhesive surface thereof facing outwardly; a first actuator connected to the other end of the first arm which rotates the first arm around the shaft so as to bring it to a position at which the roller is abutted against the circumferential surface of the web roll or to the position at which the roller is spaced from the web roll; a cutter disposed at the tip of a second arm; a second actuator connected to the second arm which rotates the second arm around theType: GrantFiled: May 16, 1989Date of Patent: November 6, 1990Assignee: Isowa-Hooper Swift, Ltd.Inventor: Masanori Kawamura
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Patent number: 4846672Abstract: A combustion cylinder structure for an oil burner capable of decreasing in the number of used parts to simplify its construction and assembling. A flame spreading cylinder arranged in an inner cylindrical member downwardly extends through a partition plate arranged in a lower end of the inner cylindrical member into a wick receiving cylinder structure. The flame spreading cylinder is concentratedly formed with a plurality of vent holes at a portion thereof in proximity to a flame spreading plate mounted on the cylinder. The partition plate is formed with a plurality of small through-holes and an inner top plate mounted on the inner cylindrical member is formed with a plurality of small through-holes. The flame spreading cylinder, outer top plate and inner top plate cooperate together to define a space to which air is supplied via the small through-holes of the partition plate and inner top plate.Type: GrantFiled: July 29, 1988Date of Patent: July 11, 1989Assignee: Toyotomi Kogyo Co., Ltd.Inventors: Masanori Kawamura, Takashi Kawai
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Patent number: 4831045Abstract: The rhodanine derivatives of the general formula: ##STR1## [wherein (I) R.sup.1 and R.sup.2 are taken together to represent a tetramethylene or pentamethylene group; (II) R.sup.1 represents a hydrogen atom, and R.sup.Type: GrantFiled: September 10, 1987Date of Patent: May 16, 1989Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Tadao Tanouchi, Masanori Kawamura, Akio Ajima, Tetsuya Mohri, Masaki Hayashi, Hiroshi Terashima, Fumio Hirata, Takeshi Morimura
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Patent number: 4791126Abstract: The rhodanine derivatives of the general formula: ##STR1## [wherein (I) R.sup.1 and R.sup.2 are taken together to represent a tetramethylene or pentamethylene group; (II) R.sup.1 represents a hydrogen atom, and R.sup.Type: GrantFiled: September 10, 1987Date of Patent: December 13, 1988Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Tadao Tanouchi, Masanori Kawamura, Akio Ajima, Tetsuya Mohri, Masaki Hayashi, Hiroshi Terashima, Fumio Hirata, Takeshi Morimura
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Patent number: 4616685Abstract: Improvement of stability of dynamic performance of pneumatic tire tread composition, by adding at least one of some esters such as phosphoric acid ester, fatty acid ester in a definite ratio to the known composition comprising styrene-rich SBR added with a processing oil and carbon black respectively in higher ratio for improving dynamic performance.Type: GrantFiled: September 24, 1984Date of Patent: October 14, 1986Inventors: Katsuyuki Harakon, Masanori Kawamura
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Patent number: 4464382Abstract: The rhodanine derivatives of the general formula: ##STR1## wherein (I) R.sup.1 and R.sup.2 are taken together to represent a tetramethylene or pentamethylene group; (II) R.sup.1 represents a hydrogen atom, and R.sup.2 represents (1) a cycloalkyl or cycloalkenyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, (2) an anthryl or naphthyl group, (3) a phenyl group which is unsubstituted or substituted, (4) a heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted (5) a ##STR2## group (wherein R.sup.4 represents a hydrogen atom, a halogen atom, phenyl group or an alkyl group of 1-5 carbon atoms; and R.sup.5 represents a hydrogen atom, a phenyl group or an alkyl group of 1-5 carbon atoms) or ##STR3## group; or (III) R.sup.1 and R.sup.2, which may be the same or different with each other, each represents a phenyl group which is unsubstituted or substituted; and R.sup.Type: GrantFiled: August 12, 1981Date of Patent: August 7, 1984Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Tadao Tanouchi, Masanori Kawamura, Akio Ajima, Tetsuya Mohri, Masaki Hayashi, Hiroshi Terashima, Fumio Hirata, Takeshi Morimura
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Patent number: 4446143Abstract: The rhodanine derivatives of the general formula: ##STR1## possess a strong inhibitory activity on aldose reductase, and are useful for the prevention and treatment of nerve disturbances such as neuralgia, retinopathy, diabetic cataract and renal disturbances such as tubular nephropathy.Type: GrantFiled: July 27, 1981Date of Patent: May 1, 1984Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Tadao Tanouchi, Satoshi Shigeoka, Masanori Kawamura, Masaki Hayashi, Hiroshi Terashima, Fumio Hirata
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Patent number: 4427682Abstract: The pyridine derivatives of the general formula: ##STR1## [wherein A represents an alkylene group containing from 1 to 5 carbon atoms unsubstituted or substituted by a hydroxy group, B represents a single bond, or an oxygen or sulphur atom, or an alkylene group containing from 1 to 5 carbon atoms, D represents a single bond, or an alkylene group containing from 1 to 5 carbon atoms, E represents a grouping of the formula: ##STR2## (in which R.sup.6 represents a hydrogen atoms, or an alkyl group containing from 1 to 4 carbon atoms), Z represents a single bond, or an ethynylene group, or a grouping of the formula: ##STR3## in which R.sup.2 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, R.sup.3 represents a hydrogen, bromine or chlorine atom, or an alkyl group containing from 1 to 4 carbon atoms, the symbol represents a single or double bond, the carbon atom attached to R.sup.2 binds to B, and the carbon atom attached to R.sup.3 binds to D, R.sup.Type: GrantFiled: December 11, 1981Date of Patent: January 24, 1984Assignees: Ono Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd.Inventors: Tadao Tanouchi, Masanori Kawamura, Masaki Havashi
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Patent number: 4374845Abstract: The imidazole derivatives of the general formula: ##STR1## (wherein R.sup.1 represents a hydrogen atom or straight- or branched-chain alkyl group of 1 to 4 carbon atoms), or pharmaceutically acceptable non-toxic salts thereof, which have a specifically inhibitory effect on the biosynthesis of thromboxane A.sub.2 (abbreviated as TXA.sub.2 hereafter) and are, therefore, useful as treating agents for disease caused by TXA.sub.2 such as inflammation, cerebral apoplexy, miocardial infarction, acute cardiac death, cardiostenosis and thrombus etc.Type: GrantFiled: October 22, 1981Date of Patent: February 22, 1983Assignees: Kissei Pharmaceutical Co., Ono Pharmaceutical Co., Ltd.Inventors: Tadao Tanouchi, Masanori Kawamura, Masaki Hayashi
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Patent number: 4360627Abstract: A rubber composition having a good reinforcing property and a remarkably improved resistance against heat build-up is disclosed, which comprises 100 parts by weight of at least one of natural rubber and synthetic rubber and 20-200 parts by weight of furnace carbon black having a specific surface area of 85-95 m.sup.2 /g, a dibutyl phthalate absorption value of 100-110 ml/100 g and a tinting strength of 95-105.Type: GrantFiled: January 29, 1981Date of Patent: November 23, 1982Assignee: Bridgestone Tire Company LimitedInventors: Yosuke Okado, Masanori Kawamura, Takashi Tomioka
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Patent number: 4355170Abstract: The imidazole derivatives of the general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms, R.sup.3 represents a straight- or branched-chain alkyl group containing from 1 to 10 carbon atoms, and m and n, which may be the same or different, each represent zero, or an integer of 1 to 10, and non-toxic acid addition salts thereof, and, when R.sup.1 represents a hydrogen atom, non-toxic salts thereof, are new compounds. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for inflammation, hypertension, thrombus, cerebral apoplexy and asthma.Type: GrantFiled: May 2, 1979Date of Patent: October 19, 1982Assignees: Ono Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd.Inventors: Masaki Hayashi, Tadao Tanouchi, Masanori Kawamura, Yoichi Iguchi
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Patent number: 4346099Abstract: The imidazole derivatives of the general formula: ##STR1## [wherein m represents an integer of 4 to 9, R.sup.1 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, and one of R.sup.2 and R.sup.3 represents a hydrogen atom, and the other represents a halogen atom or a phenyl group, or R.sup.2 and R.sup.3 together represent --(CH.sub.2).sub.n --(in which n represents an integer of 4 to 6) or represent .dbd.CH.sub.2 ] and non-toxic salts thereof, which have a specifically inhibitory effect on the biosynthesis of thromboxane A.sub.2 (abbreviated as TXA.sub.2 hereafter) and are, therefore, useful as treating agents for diseases caused by TXA.sub.2 such as inflammation, cerebral apoplexy, myocardial infarction, acute cardiac death, cardiostenosis and thrombus etc.Type: GrantFiled: September 22, 1981Date of Patent: August 24, 1982Assignees: Ono Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd.Inventors: Tadao Tanouchi, Masanori Kawamura, Takanori Okada, Masaki Hayashi
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Patent number: 4317828Abstract: The pyridine derivatives of the general formula: ##STR1## [wherein A represents an alkylene group containing from 1 to 5 carbon atoms unsubstituted or substituted by a hydroxy group, B represents a single bond, or an oxygen or sulphur atom, or an alkylene group containing from 1 to 5 carbon atoms, D represents a single bond, or an alkylene group containing from 1 to 5 carbon atoms, E represents a grouping of the formula: ##STR2## (in which R.sup.6 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms), Z represents a single bond, or an ethynylene group, or a grouping of the formula: ##STR3## in which R.sup.2 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, R.sup.3 represents a hydrogen, bromine or chlorine atom, or an alkyl group containing from 1 to 4 carbon atoms, the symbol represents a single or double bond, the carbon atom attached to R.sup.2 binds to B, and the carbon atom attached to R.sup.3 binds to D, R.sup.Type: GrantFiled: February 12, 1981Date of Patent: March 2, 1982Assignees: Ono Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd.Inventors: Tadao Tanouchi, Masanori Kawamura, Masaki Hayashi
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Patent number: 4271170Abstract: The pyridine derivatives of the general formula: ##STR1## [wherein A represents an alkylene group containing from 1 to 5 carbon atoms unsubstituted or substituted by a hydroxy group, B represents a single bond, or an oxygen or sulphur atom, or an alkylene group containing from 1 to 5 carbon atoms, D represents a single bond, or an alkylene group containing from 1 to 5 carbon atoms, R represents a grouping of the formula: ##STR2## (in which R.sup.6 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms), Z represents a single bond, or an ethynylene group, or a grouping of the formula: ##STR3## in which R.sup.2 represents a hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms, R.sup.3 represents a hydrogen, bromine or chlorine atom, or an alkyl group containing from 1 to 4 carbom atoms; the symbol represents a single or double bond, the carbon atom attached to R.sup.2 binds to B, and the carbon atom attached to R.sup.3 binds to D, R.sup.Type: GrantFiled: December 20, 1979Date of Patent: June 2, 1981Assignees: Ono Pharmaceutical Co., Ltd.,, Kissei Pharmaceutical Co., Ltd.Inventors: Tadao Tanouchi, Masanori Kawamura, Masaki Hayashi
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Patent number: 4256757Abstract: The imidazole derivatives of the general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, the symbol .dbd. represents a double bond that bond is E or Z, or a triple bond, and m and n, which may be the same or different, each represent zero, or an integer of 1 to 10, and non-toxic acid addition salts thereof, and, when R.sup.1 represents a hydrogen atom, non-toxic salts thereof are new compounds. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for inflammation, hypertension, thrombus, cerebral apoplexy and asthma.Type: GrantFiled: May 2, 1979Date of Patent: March 17, 1981Assignees: Ono Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd.Inventors: Masaki Hayashi, Tadao Tanouchi, Masanori Kawamura, Ikuo Kajiwara
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Patent number: 3961248Abstract: A gas detector comprises a plurality of semiconductor gas detector elements each exhibiting a different sensitivity for at least one gaseous conponent. The elements are electrically combined in an electrical circuit to provide an output indicating the existence of a particular gas in an atmosphere.Type: GrantFiled: July 2, 1974Date of Patent: June 1, 1976Assignee: Nohmi Bosai Kogyo Co. Ltd.Inventor: Masanori Kawamura