Abstract: Provided are a pharmaceutical composition for treating an FLT3 mutation-positive cancer; a mutant FLT3 inhibitor; and uses thereof.

Abstract: Provided are a pharmaceutical composition for treating an FLT3 mutation-positive cancer; a mutant FLT3 inhibitor; and uses thereof.

Abstract: The object is to provide an Fms-like tyrosine kinase 3 (FLT3) inhibitor useful as a therapeutic agent for acute myeloid leukemia (AML). A novel nitrogen-containing heterocyclic compound represented by the general formula [1] or a salt thereof is provided. The compound or a salt thereof of the present invention can be used as an active ingredient of a pharmaceutical composition for a treatment of a disease or condition relating to FLT3, such as acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL).

Abstract: The object is to provide an Fms-like tyrosine kinase 3 (FLT3) inhibitor useful as a therapeutic agent for acute myeloid leukemia (AML). A novel nitrogen-containing heterocyclic compound represented by the general formula [1] or a salt thereof is provided. The compound or a salt thereof of the present invention can be used as an active ingredient of a pharmaceutical composition for a treatment of a disease or condition relating to FLT3, such as acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL).

Abstract: Provided is an azo pigment represented by the following general formula (1), a tautomer of the azo pigment, and a salt or a hydrate thereof: wherein Q represents the non-metallic atoms necessary to complete a 5- to 7-membered heterocyclic group, W represents an alkoxy group, an amino group, an alkyl group, or an aryl group, X1 and X2 each independently represents a hydrogen, an alkyl group, an acyl group, an alkylsulfonyl group, or an arylsulfonyl group, R1 represents a hydrogen or a substituent, R2 represents a heterocyclic group, n represents an integer of from 1 to 4 and the general formula (1) represents a dimer formed through Q, W, X1, X2, R1, or R2 when n=2, a trimer formed through Q, W, X1, X2, R1, or R2 when n=3, and a tetramer formed through Q, W, X1, X2, R1, or R2 when n=4.

Abstract: An ink set includes at least a magenta ink composition and a cyan ink composition, wherein the magenta ink composition includes: at least one colorant selected from the group consisting of specific heterylazo dyes; and at least one colorant selected from the group consisting of specific anthrapyridone dyes, and the cyan ink composition includes at least one colorant selected from the group consisting of phthalocyanine compounds meeting requirements 1 and 2: Requirement 1: The ratio of the maximum absorbance within the absorption band of from 660 nm to 680 nm to the maximum absorbance within the absorption band of from 600 nm to 640 nm on the spectral absorption curve of aqueous solution is less than 1; and Requirement 2: The oxidation potential is more positive than 1.0 eV (vsSCE).

Abstract: Provided is an azo pigment represented by the following general formula (1), a tautomer of the azo pigment, and a salt or a hydrate thereof: wherein Q represents the non-metallic atoms necessary to complete a 5- to 7-membered heterocyclic group, W represents an alkoxy group, an amino group, an alkyl group, or an aryl group, X1 and X2 each independently represents a hydrogen, an alkyl group, an acyl group, an alkylsulfonyl group, or an arylsulfonyl group, R1 represents a hydrogen or a substituent, R2 represents a heterocyclic group, n represents an integer of from 1 to 4 and the general formula (1) represents a dimer formed through Q, W, X1, X2, R1, or R2 when n=2, a trimer formed through Q, W, X1, X2, R1, or R2 when n=3, and a tetramer formed through Q, W, X1, X2, R1, or R2 when n=4.

Abstract: An ink set includes at least a magenta ink composition and a cyan ink composition, wherein the magenta ink composition comprises: at least one colorant selected from the group consisting of specific heterylazo dyes; and at least one colorant selected from the group consisting of specific anthrapyridone dyes, and the cyan ink composition comprises at least one colorant selected from the group consisting of phthalocyanine compounds meeting requirements 1 and 2: Requirement 1: The ratio of the maximum absorbance within the absorption band of from 660 nm to 680 nm to the maximum absorbance within the absorption band of from 600 nm to 640 nm on the spectral absorption curve of aqueous solution is less than 1; and Requirement 2: The oxidation potential is more positive than 1.0 eV (vsSCE).

Abstract: A process for producing a 5-aminopyrazole derivative represented by Formula (I) includes a step of reacting a hydrazine compound represented by Formula (II) with a compound represented by Formula (III) under a condition satisfying Reaction Condition 1 and Reaction Condition 2, wherein Reaction Condition 1 is that the reaction is conducted in a reaction solvent containing water, and Reaction Condition 2 is that pH of a liquid mixture containing the hydrazine compound represented by Formula (II), the compound represented by Formula (III), the reaction solvent, and an acidifying agent upon charging is within a range of from 2.0 to 4.0 at 25° C.: wherein the symbols in the formulae (I) to (III) are defined in the specification.

Abstract: An azo dye represented by formula (II) as defined in the specification, a process of producing the same and a coloring composition containing the azo dye.

Abstract: An ink composition which comprises: a dye which is represented by formula (1), which is described in the specification, and has at least one ionic hydrophilic group, wherein the dye has a molecular weight of from 310 to 500 per one ionic hydrophilic group, and a recording method which comprises: discharging ink droplets of the ink composition onto plain paper.

Abstract: An ink containing an azo dye having, in total, at least 13 conjugated ? electrons in an aromatic ring thereof that is not directly bonded to any azo group.

Abstract: An ink composition which comprises: a dye which is represented by formula (1), which is described in the specification, and has at least one ionic hydrophilic group, wherein the dye has a molecular weight of from 310 to 500 per one ionic hydrophilic group, and a recording method which comprises: discharging ink droplets of the ink composition onto plain paper.

Abstract: The invention provides a water-soluble ink capable of forming an image having good color hue and high fastness in various use and environmental conditions, which comprises a coloring composition comprising a disazo dye represented by the following formula 1: A1-N?N-A2-N?N-A3 and at least one other dye having a specific structure; in formula 1, A1, A2 and A3 each independently represents an aromatic group which may be substituted or a heterocyclic group which may be substituted, and A1 and A3 each is a monovalent group and A2 is a divalent group.

Abstract: A coloring composition comprising a dye compound represented by formula (I): wherein Dye represents a dye structure portion; Q represents —SO—, —SO2—, —SO2NR11—, —CO— or —CONR12— in which R11 and R12 each independently represents a hydrogen atom or a substituent; W represents a divalent aliphatic group; M represents an ionic group; and m represents an integer of 1 or greater, and wherein the dye compound satisfies conditions 1 and 2: Condition 1: 200<Mw/(the number of CO2M groups contained in the dye compound)<500 Condition 2: (the number of CO2M groups contained in the dye compound)/p>0.5, with the proviso that Mw represents a molecular weight of the dye compound represented by the formula (1); and p represents the total number of ionic hydrophilic groups substituted on the dye compound represented by the formula (1).

Abstract: An aqueous ink comprising at least two dyes each having at least one ionic hydrophilic group in a molecule thereof, wherein at least one of said at least two dyes includes an azo dye represented by formula (1): wherein A and B each independently represents a substituted or unsubstituted monovalent aromatic group; or a substituted or unsubstituted monovalent heterocyclic group; R1 represents a hydrogen atom; a substituted or unsubstituted aromatic group; or a substituted or unsubstituted heterocyclic group; and X represents —CR2? or a nitrogen atom, and when X represents —CR2?, R2 represents a hydrogen atom or a substituent.

Abstract: An aqueous ink comprising at least one dye having at least one ionic hydrophilic group within a molecule thereof and represented by the following formula (1): wherein A and B each independently represents a substituted or unsubstituted monovalent aromatic group or a substituted or unsubstituted monovalent heterocyclic group, R1 represents a substituted or unsubstituted aromatic group excluding an unsubstituted phenyl group or a substituted or unsubstituted heterocyclic group, and R2 represents a substituent.

Abstract: An ink containing an azo dye having, in total, at least 13 conjugated ? electrons in an aromatic ring thereof that is not directly bonded to any azo group.

Abstract: An azo dye represented by formula (II) as defined in the specification, a process of producing the same and a coloring composition containing the azo dye.

Abstract: An aqueous ink comprising at least two dyes each having at least one ionic hydrophilic group in a molecule thereof, wherein at least one of said at least two dyes includes an azo dye represented by formula (1): wherein A and B each independently represents a substituted or unsubstituted monovalent aromatic group; or a substituted or unsubstituted monovalent heterocyclic group; R1 represents a hydrogen atom; a substituted or unsubstituted aromatic group; or a substituted or unsubstituted heterocyclic group; and X represents —CR2? or a nitrogen atom, and when X represents —CR2?, R2 represents a hydrogen atom or a substituent.