Abstract: The present invention aims to provide a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease, which has a novel action mechanism and shows less side effects. A polyphenol derivative having liposolubility enhanced by the introduction of at least one kind of a liposoluble group selected from the group consisting of a chain saturated hydrocarbon group, a chain unsaturated hydrocarbon group, a cyclic saturated hydrocarbon group, a cyclic unsaturated hydrocarbon group, an aromatic hydrocarbon group, a liposoluble vitamin residue and a sterol residue has an action to potentiate neprilysin activity, and is useful as a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease.

Abstract: The present invention aims to provide a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease, which has a novel action mechanism and shows less side effects. A polyphenol derivative having liposolubility enhanced by the introduction of at least one kind of a liposoluble group selected from the group consisting of a chain saturated hydrocarbon group, a chain unsaturated hydrocarbon group, a cyclic saturated hydrocarbon group, a cyclic unsaturated hydrocarbon group, an aromatic hydrocarbon group, a liposoluble vitamin residue and a sterol residue has an action to potentiate neprilysin activity, and is useful as a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease.

Abstract: The present invention provides a method for screening a therapeutic and/or prophylactic agent for Alzheimer's disease using at least one index selected from the levels of A? oligomers, BiP, cleaved caspase 4, PRDX4 and ROS in nerve cells or the like whose differentiation has been induced from iPS cells derived from somatic cells of a patient with Alzheimer's disease.

Abstract: The present invention provides a method for screening a therapeutic and/or prophylactic agent for Alzheimer's disease using at least one index selected from the group consisting of the levels of A? oligomers, BiP, cleaved caspase 4, PRDX4 and ROS in nerve cells or the like whose differentiation has been induced from iPS cells derived from somatic cells of a patient with Alzheimer's disease.

Abstract: The present invention provides a needle thread feeding device for a multi-needle embroidery sewing machine which includes a drive roller having a length that extends across the plurality of needle threads, a needle thread guide mechanism that arranges the needle threads side by side in an axial direction of the drive roller and guides the needle threads, a pressure roller that presses the selected needle thread onto the drive roller, and a thread distributing mechanism that relatively moves the needle thread guide mechanism and the pressure roller in the axial direction of the drive roller in synchronization with movement of the sewing machine head. The thread distributing mechanism interposes the selected needle thread between the drive roller and the pressure roller.

Abstract: The present invention provides a needle thread feeding device for a multi-needle embroidery sewing machine which includes a drive roller having a length that extends across the plurality of needle threads, a needle thread guide mechanism that arranges the needle threads side by side in an axial direction of the drive roller and guides the needle threads, a pressure roller that presses the selected needle thread onto the drive roller, and a thread distributing mechanism that relatively moves the needle thread guide mechanism and the pressure roller in the axial direction of the drive roller in synchronization with movement of the sewing machine head. The thread distributing mechanism interposes the selected needle thread between the drive roller and the pressure roller.

Abstract: A method of creating data for an applique which has its lower and upper applique patches embroidered to lower and upper cloths, respectively, such that the lower cloth and applique patch and the upper cloth and applique patch can overlap and separate each other with a predetermined overlap margin. The applique data creating method includes the steps of: inputting synthetic contour data of the two applique patches when the lower and upper applique patches overlap each other with the predetermined overlap margin; inputting the individual overlap edge data of the lower and upper applique patches; creating the individual contour data of the lower and upper applique patches from the synthetic contour data and the individual overlap edge data; and creating the individual embroidering data of the lower and upper applique patches on the basis of the individual contour data of the lower and upper applique patches.

Abstract: A leadframe includes a first longitudinal side band, a second longitudinal side band integrally connected to the first band by transverse sectioning bars spaced longitudinally of the leadframe, a plurality of first leads located closer to the first side band between the respective sectioning bars, and a plurality of second leads integrally connected to the second side band between the respective sectioning bars. The first leads are integrally connected to the respective sectioning bars only via twistably slenderized segments. Each first lead can be turned over toward a corresponding second lead by torsioning the twistable segments.