Patents by Inventor Masashi Hakamata
Masashi Hakamata has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8749787Abstract: Excitation light beam is irradiated onto a test region while shifting the irradiation position thereof, when performing analysis of a target substance using an analysis chip having the test region within a flow channel through which a sample solution is caused to flow, for capturing the target substance within the sample solution. Fluorescence generated at the test region is detected as a plurality of adjustment fluorescence signals. The target substance is analyzed using fluorescence generated when the excitation light beam is irradiated at an irradiation position within the test region determined based on the plurality of adjustment fluorescence signals.Type: GrantFiled: March 10, 2011Date of Patent: June 10, 2014Assignee: Fujifilm CorporationInventors: Junpei Shiraishi, Masashi Hakamata
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Patent number: 8665444Abstract: The shape of a prism is set such that an excitation light beam that enters the prism to cause surface plasmon resonance to be generated is not irradiated onto the corners of the prism after being totally reflected within the prism. The angle of a surface that the excitation light exits the prism is set to an angle at which the excitation light beam is not totally reflected. Thereby, the excitation light beam returning to a light source, and being scattered within the prism are prevented, and therefore the accuracy of measurements can be improved.Type: GrantFiled: March 30, 2011Date of Patent: March 4, 2014Assignee: Fujifilm CorporationInventor: Masashi Hakamata
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Publication number: 20140049774Abstract: A dew condensation detection device includes: a light emitting unit for emitting a light flux that travels along a dew condensation detection surface of a member having the dew condensation detection surface; a changing unit for changing a diameter of the light flux; and an optical detector for receiving the light flux that has passed along the dew condensation detection surface.Type: ApplicationFiled: September 27, 2013Publication date: February 20, 2014Applicant: FUJIFILM CorporationInventors: Kazuyoshi HORII, Masashi HAKAMATA
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Publication number: 20110240879Abstract: Excitation light beam is irradiated onto a test region while shifting the irradiation position thereof, when performing analysis of a target substance using an analysis chip having the test region within a flow channel through which a sample solution is caused to flow, for capturing the target substance within the sample solution. Fluorescence generated at the test region is detected as a plurality of adjustment fluorescence signals. The target substance is analyzed using fluorescence generated when the excitation light beam is irradiated at an irradiation position within the test region determined based on the plurality of adjustment fluorescence signals.Type: ApplicationFiled: March 10, 2011Publication date: October 6, 2011Applicant: FUJIFILM CORPORATIONInventors: Junpei SHIRAISHI, Masashi HAKAMATA
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Publication number: 20110242541Abstract: The shape of a prism is set such that an excitation light beam that enters the prism to cause surface plasmon resonance to be generated is not irradiated onto the corners of the prism after being totally reflected within the prism. The angle of a surface that the excitation light exits the prism is set to an angle at which the excitation light beam is not totally reflected. Thereby, the excitation light beam returning to a light source, and being scattered within the prism are prevented, and therefore the accuracy of measurements can be improved.Type: ApplicationFiled: March 30, 2011Publication date: October 6, 2011Applicant: FUJIFILM CORPORATIONInventor: Masashi Hakamata
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Publication number: 20110236262Abstract: A biological substance detecting apparatus that enables stable detection and quantitative analysis of biologically derived target substances is provided. The biological substance detecting apparatus employs a sensor chip provided with a fine flow channel through which a sample liquid is caused to flow, and a sensor surface that adsorbs a biologically derived target substance. Light is irradiated onto the sensor surface, and light emitted by the adsorbed target substance or a labeling substance bound thereto is detected. A flow speed controlling means, for controlling the flow speed of the sample liquid that flows through the fine flow channel to a value within a range such that the adsorption speed of the target substance is not controlled by dispersion.Type: ApplicationFiled: March 24, 2011Publication date: September 29, 2011Applicant: FUJIFILM CORPORATIONInventors: Kazuyoshi HORII, Tomonari Sendai, Akihiro Komatsu, Mitsuaki Uchida, Masashi Hakamata, Junpei Shiraishi, Daisuke Hibe, Yasunori Ohta, Akira Ito
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Patent number: 7830521Abstract: Provided are a detection apparatus, a detection method and an optically transparent member, which can detect a decrease in a precision. A convolution is performed by a convolution portion 80 contained in an image processing portion 38, to acquire the distribution information indicating the light intensity distribution of a light beam, which is totally reflected at the interface and which is incident at a plurality of angles to an dielectric block 52 so as to be totally reflected at the interface of the dielectric block 52. A spatial frequency resolution is performed on the light intensity distribution indicated by the distribution information acquired, by a detection precision evaluating portion 86 contained in the image processing portion 38, to thereby derive the light intensity distribution of each spatial frequency of the light beam. The precision is detected by comparing the light intensity distribution derived, with a threshold value predetermined for each spatial frequency.Type: GrantFiled: September 28, 2007Date of Patent: November 9, 2010Assignee: Fujifilm CorporationInventors: Hiroaki Yamamoto, Toshihito Kimura, Hitoshi Shimizu, Masashi Hakamata
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Patent number: 7740908Abstract: It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a method for producing a solid substrate for sensors that has a coating on the surface using spin coating, wherein a substrate to be coated is rotated in an atmosphere in which the vapor pressure of coating solvent is 50% to 100% with respect to the saturation vapor pressure so as to form a thin film of a coating solution on said substrate to be coated.Type: GrantFiled: February 28, 2006Date of Patent: June 22, 2010Assignee: FUJIFILM CorporationInventors: Yukou Saito, Masashi Hakamata
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Publication number: 20080079951Abstract: Provided are a detection apparatus, a detection method and an optically transparent member, which can detect a decrease in a precision. A convolution is performed by a convolution portion 80 contained in an image processing portion 38, to acquire the distribution information indicating the light intensity distribution of a light beam, which is totally reflected at the interface and which is incident at a plurality of angles to an dielectric block 52 so as to be totally reflected at the interface of the dielectric block 52. A spatial frequency resolution is performed on the light intensity distribution indicated by the distribution information acquired, by a detection precision evaluating portion 86 contained in the image processing portion 38, to thereby derive the light intensity distribution of each spatial frequency of the light beam. The precision is detected by comparing the light intensity distribution derived, with a threshold value predetermined for each spatial frequency.Type: ApplicationFiled: September 28, 2007Publication date: April 3, 2008Applicant: Fujifilm CorporationInventors: Hiroaki YAMAMOTO, Toshihito Kimura, Hitoshi Shimizu, Masashi Hakamata
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Publication number: 20070259193Abstract: It is an object of the present invention to provide a method for producing a solid substrate used for sensors having a film with a small film thickness distribution, and a solid surface used for sensors having a film with a small film thickness distribution. The present invention provides a method for producing a solid substrate for sensors that has a coating on the surface using spin coating, wherein a substrate to be coated is rotated in an atmosphere in which the vapor pressure of coating solvent is 50% to 100% with respect to the saturation vapor pressure so as to form a thin film of a coating solution on said substrate to be coated.Type: ApplicationFiled: February 28, 2006Publication date: November 8, 2007Inventors: Yukou Saito, Masashi Hakamata
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Publication number: 20070243633Abstract: An object of the present invention is to provide a biosensor which exhibits good reproducibility of the amount of an immobilized physiologically active substance by suppressing plane deterioration (separation of a metal film from a resin) which occurs at the formation of a thin metal film layer on a resin surface. The present invention provides a biosensor which is produced by performing plasma irradiation on a light-reflecting surface of an optical block which is obtained by molding a resin and has at least 3 surfaces including a light incident surface, the light-reflecting surface and a light-emerging surface; forming a first metal layer; and then forming a second metal layer on the side of the first metal layer which is opposite to the light-reflecting surface.Type: ApplicationFiled: September 29, 2005Publication date: October 18, 2007Inventors: Masashi Hakamata, Toshiaki Kubo
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Patent number: 7193703Abstract: A surface plasmon resonance sensor unit includes a prism. A thin film has a first surface and a sensing surface. The first surface overlies the prism to constitute a thin film/prism interface. The sensing surface immobilizes a sample in sample fluid. Illuminating light is applied to the interface in a form satisfying a condition for total internal reflection, to create attenuated total reflection in the illuminating light reflected by the interface. An angle of incidence of the illuminating light upon the attenuated total reflection is changed upon (bio)chemical reaction of the sample on the sensing surface. The sensor unit includes an enclosing cover, secured to the prism, for covering the sensing surface. A lower recess is formed in the prism, and positioned at the sensing surface. The lower recess constitutes a flow channel for flow of the sample fluid on the sensing surface.Type: GrantFiled: January 3, 2006Date of Patent: March 20, 2007Assignee: Fuji Photo Film Co. Ltd.Inventors: Masashi Hakamata, Tatsuo Fujikura
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Publication number: 20060211137Abstract: It is an object of the present invention to provide a biosensor wherein a reference unit and a measurement unit can be prepared by performing only a single operation for immobilizing a physiologically active substance and wherein unnecessary electric charge does not remain in the reference unit. The present invention provides a biosensor which comprises a substrate composed of a metal surface or metal film coated with a hydrophilic polymer compound, and which has a surface for retaining a physiologically active substance and a surface that does not retain a physiologically active substance on a single plane of the substrate.Type: ApplicationFiled: February 27, 2006Publication date: September 21, 2006Inventors: Toshihide Ezoe, Toshiaki Kubo, Masashi Hakamata
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Publication number: 20060146333Abstract: A surface plasmon resonance sensor unit includes a prism. A thin film has a first surface and a sensing surface. The first surface, overlies the prism to constitute a thin film/prism interface. The sensing surface immobilizes a sample in sample fluid. Illuminating light is applied to the interface in a form satisfying a condition for total internal reflection, to create attenuated total reflection in the illuminating light reflected by the interface. An angle of incidence of the illuminating light upon the attenuated total reflection is changed upon (bio)chemical reaction of the sample on the sensing surface. The sensor unit includes an enclosing cover, secured to the prism, for covering the sensing surface. A lower recess is formed in the prism, and positioned at the sensing surface. The lower recess constitutes a flow channel for flow of the sample fluid on the sensing surface.Type: ApplicationFiled: January 3, 2006Publication date: July 6, 2006Inventors: Masashi Hakamata, Tatsuo Fujikura
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Publication number: 20050069937Abstract: In a biochemical analysis unit, a membrane is pressed into through holes formed in a substrate to form plural spot areas in each through hole, and the remaining membrane forms a thin layer on a rear face of the substrate. A probe solution is spotted on each spot area by a spot head. On the occasion of the spotting, a pin arrangement plate presses the biochemical analysis unit from the rear face. On the pin arrangement plate, pins are arranged at the same pitch as the spot areas. The pin arrangement plate is positioned such that the pins confront the corresponding spot areas. When the pressing is made, the pins push the thin layer to enter the corresponding through holes. Thus the pores in the thin layer are squashed, and it is prevented that the probe solution penetrate into the neighboring spot areas.Type: ApplicationFiled: September 29, 2004Publication date: March 31, 2005Inventors: Nobuhiko Ogura, Masashi Hakamata
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Publication number: 20040132081Abstract: A DNA chip favorably employable for detecting a DNA fragment complementary to the oligo- or polynucleotide fixed to the chip is composed of a solid carrier and oligonucleotide or polynucleotide which is fixed to the carrier in the presence of a hydrophilic polymer.Type: ApplicationFiled: December 16, 2003Publication date: July 8, 2004Inventors: Satoru Kuhara, Kosuke Tashiro, Shigeru Muta, Tohru Tsuchiya, Masashi Hakamata
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Patent number: D561053Type: GrantFiled: September 21, 2006Date of Patent: February 5, 2008Assignee: Fujifilm CorporationInventors: Nobuhiko Ogura, Katsuaki Muraishi, Hitoshi Shimizu, Masashi Hakamata, Yasunobu Sakaguchi, Yoshiyuki Kunuki
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Patent number: D561054Type: GrantFiled: September 22, 2006Date of Patent: February 5, 2008Assignee: Fujifilm CorporationInventors: Nobuhiko Ogura, Katsuaki Muraishi, Hitoshi Shimizu, Masashi Hakamata, Yasunobu Sakaguchi, Yoshiyuki Kunuki
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Patent number: D561623Type: GrantFiled: September 22, 2006Date of Patent: February 12, 2008Assignee: Fujifilm CorporationInventors: Nobuhiko Ogura, Katsuaki Muraishi, Hitoshi Shimizu, Masashi Hakamata, Yasunobu Sakaguchi, Hideyuki Morimoto, Hiroyuki Ota, Masayasu Konishi, Yoshiyuki Kunuki
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Patent number: D561624Type: GrantFiled: September 22, 2006Date of Patent: February 12, 2008Assignee: Fujifilm CorporationInventors: Nobuhiko Ogura, Katsuaki Muraishi, Masashi Hakamata, Hideyuki Morimoto, Hiroyuki Ota