Patents by Inventor Masashi Isozaki
Masashi Isozaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9592322Abstract: A coating composition for drug eluting medical devices, which is capable of forming a drug coating layer that is not susceptible to peeling during delivery to a target tissue is provided. This coating composition contains: a water-insoluble drug; at least one selected from the group consisting of hyaluronic acid, alkanoyl hyaluronic acids obtained by substituting at least part of hydrogen atoms in the hydroxyl groups of hyaluronic acid with an alkanoyl group, and salts of hyaluronic acid and the alkanoyl hyaluronic acids; and at least one selected from the group consisting of amino-acid esters and salts thereof. A drug coating layer, a medical device and a method of treatment are also provided.Type: GrantFiled: September 25, 2014Date of Patent: March 14, 2017Assignee: TERUMO KABUSHIKI KAISHAInventors: Keiko Yamashita, Shigenori Nozawa, Masashi Isozaki
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Publication number: 20150057746Abstract: A coating composition for drug eluting medical devices, which is capable of forming a drug coating layer that is not susceptible to peeling during delivery to a target tissue is provided. This coating composition contains: a water-insoluble drug; at least one selected from the group consisting of hyaluronic acid, alkanoyl hyaluronic acids obtained by substituting at least part of hydrogen atoms in the hydroxyl groups of hyaluronic acid with an alkanoyl group, and salts of hyaluronic acid and the alkanoyl hyaluronic acids; and at least one selected from the group consisting of amino-acid esters and salts thereof. A drug coating layer, a medical device and a method of treatment are also provided.Type: ApplicationFiled: September 25, 2014Publication date: February 26, 2015Applicant: TERUMO KABUSHIKI KAISHAInventors: Keiko YAMASHITA, Shigenori NOZAWA, Masashi ISOZAKI
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Patent number: 8945526Abstract: The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.Type: GrantFiled: June 15, 2007Date of Patent: February 3, 2015Assignees: Shimadzu Corporation, Kyoto UniversityInventors: Hitoshi Akitsu, Eiichi Ozeki, Ryoji Fushimi, Shunsaku Kimura, Masashi Isozaki, Shigenori Nozawa
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Patent number: 8241663Abstract: A liposome preparation is provided. This liposome preparation is capable of stably encapsulating a drug which is unstable under an acidic condition, and such stable encapsulation is realized without detracting the effect realized by the modification of the membrane by a hydrophilic macromolecule such as stability in blood. More specifically, the liposome preparation comprises a unilamellar vesicle formed from a lipid bilayer comprising a phospholipid as its main membrane component, and an interior aqueous phase of the vesicle at a pH of up to 5. The liposome has a drug loaded therein, and the vesicle is modified with a hydrophilic macromolecule only on its exterior surface.Type: GrantFiled: March 25, 2005Date of Patent: August 14, 2012Assignee: Terumo Kabushiki KaishaInventors: Masashi Isozaki, Keisuke Yoshino, Kyoko Taguchi, Masayo Kondo
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Patent number: 7846473Abstract: Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.Type: GrantFiled: May 31, 2005Date of Patent: December 7, 2010Assignees: Terumo Kabushiki Kaisha, Kabushiki Kaisha Yakult HonshaInventors: Keisuke Yoshino, Shigenori Nozawa, Masashi Isozaki, Seigo Sawada, Ikuo Kato, Takeshi Matsuzaki
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Patent number: 7812155Abstract: A process for preparing an o-alkylated rapamycin derivative represented by the following general formula (1) is provided. The process includes the steps of reacting rapamycin with an alkyl triflate, purifying the resulting reaction product with a normal phase chromatograph and further purifying a purified product, which has been purified with the normal phase chromatograph, with a reverse phase chromatography wherein R represents an alkyl, arylalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, or aryl.Type: GrantFiled: November 26, 2007Date of Patent: October 12, 2010Assignee: Terumo Kabushiki KaishaInventors: Tetsuro Kawanishi, Masashi Isozaki
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Publication number: 20080279916Abstract: A liposome preparation is provided. This liposome preparation is capable of stably encapsulating a drug which is unstable under an acidic condition, and such stable encapsulation is realized without detracting the effect realized by the modification of the membrane by a hydrophilic macromolecule such as stability in blood. More specifically, the liposome preparation comprises a unilamellar vesicle formed from a lipid bilayer comprising a phospholipid as its main membrane component, and an interior aqueous phase of the vesicle at a pH of up to 5. The liposome has a drug loaded therein, and the vesicle is modified with a hydrophilic macromolecule only on its exterior surface.Type: ApplicationFiled: March 25, 2005Publication date: November 13, 2008Applicant: TERUMO KABUSHIKI KAISHAInventors: Masashi Isozaki, Keisuke Yoshino, Kyoko Taguchi, Masayo Kondo
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Publication number: 20080146796Abstract: A process for preparing an o-alkylated rapamycin derivative represented by the following general formula (1) is provided. The process includes the steps of reacting rapamycin with an alkyl triflate, purifying the resulting reaction product with a normal phase chromatograph and further purifying a purified product, which has been purified with the normal phase chromatograph, with a reverse phase chromatography wherein R represents an alkyl, arylalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, or aryl.Type: ApplicationFiled: November 26, 2007Publication date: June 19, 2008Applicant: Terumo Kabushiki KaishaInventors: Tetsuro Kawanishi, Masashi Isozaki
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Publication number: 20080069868Abstract: Provided is an irinotecan formulation capable of supporting irinotecan and/or a salt thereof in a closed vesicle carrier at a high concentration and existing in blood for a long period of time by dramatically improved retentivity in blood compared to a conventionally known irinotecan liposome formulation. That is, an irinotecan formulation including a closed vesicle formed by a lipid membrane, in which irinotecan and/or a salt thereof is encapsulated at a concentration of at least 0.07 mol/mol (drug mol/membrane total lipid mol). There is an ion gradient between an inner aqueous phase and an outer aqueous phase in the irinotecan formulation. The closed vesicle is preferably liposome, in which only the outer surface of the liposome is preferably modified with a surface-modifying agent containing a hydrophilic polymer.Type: ApplicationFiled: May 31, 2005Publication date: March 20, 2008Applicants: TERUMO KABUSHIKI KAISHA, KABUSHIKI KAISHA YAKULT HONSHAInventors: Keisuke Yoshino, Shigenori Nozawa, Masashi Isozaki, Seigo Sawada, Ikuo Kato, Takeshi Matsuzaki
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Publication number: 20080019908Abstract: The present invention provides a novel amphiphilic substance, a nanoparticle using the novel amphiphilic substance, which can be used as a nanocarrier having high biocompatibility, a drug delivery system and a probe useful for the system, and, a molecular imaging system and a probe useful for the system. An amphiphilic block polymer comprising a hydrophilic block; and a hydrophobic block, wherein the hydrophilic block is a hydrophilic polypeptide chain having 10 or more sarcosine units, and the hydrophobic block is a hydrophobic molecular chain comprising units selected from the group consisting of amino acid units and hydroxyl acid units as essential structural units, and having 5 or more of the essential structural units.Type: ApplicationFiled: June 15, 2007Publication date: January 24, 2008Applicants: SHIMADZU CORPORATION, KYOTO UNIVERSITY, TERUMO CORPORATIONInventors: Hitoshi Akitsu, Eiichi Ozeki, Ryoji Fushimi, Shunsaku Kimura, Masashi Isozaki, Shigenori Nozawa
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Publication number: 20070298094Abstract: A medicinal composition and a medicinal preparation which are capable of inhibiting complement activation. The medicinal composition comprises: a medicinal preparation modified with a first hydrophilic polymer; and a second hydrophilic polymer. The medicinal preparation contains as an active ingredient a second hydrophilic polymer which inhibits an immunoreaction caused by a medicinal preparation modified with a first hydrophilic polymer.Type: ApplicationFiled: November 16, 2005Publication date: December 27, 2007Applicant: TERUMO KABUSHIKI KAISHAInventors: Keisuke Yoshino, Masashi Isozaki, Katsumi Morimoto, Miyuki Shimizu
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Publication number: 20070160646Abstract: A stent coated by a compound represented by the general formula (1) below which is produced by reaction between rapamycin and alkyl triflate in an organic solvent which is a chlorine-containing organic solvent, wherein said reaction is carried out in the presence of trialkylamine, where R denotes alkyl, arylalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, or aryl.Type: ApplicationFiled: March 19, 2007Publication date: July 12, 2007Applicant: Terumo Kabushiki KaishaInventors: Masashi Isozaki, Tetsuro Kawanishi
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Patent number: 7193078Abstract: Disclosed herein is a process for production of an O-alkylrapamycin derivative represented by the general formula (1) below by reaction between rapamycin and alkyl triflate in an organic solvent, characterized in that the reaction is carried out in the presence of trialkylamine. (where R denotes alkyl, arylalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, or aryl.) This process is capable of producing O-alkylrapamycin derivative efficiently owing to improvement in reaction yields for O-alkylation.Type: GrantFiled: March 1, 2005Date of Patent: March 20, 2007Assignee: Terumo Kabushiki KaishaInventors: Masashi Isozaki, Tetsuro Kawanishi
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Publication number: 20050192311Abstract: Disclosed herein is a process for production of an O-alkylrapamycin derivative represented by the general formula (1) below by reaction between rapamycin and alkyl triflate in an organic solvent, characterized in that the reaction is carried out in the presence of trialkylamine. (where R denotes alkyl, arylalkyl, hydroxyalkyl, alkoxyalkyl, acyloxyalkyl, aminoalkyl, alkylaminoalkyl, alkoxycarbonylaminoalkyl, acylaminoalkyl, or aryl.) This process is capable of producing O-alkylrapamycin derivative efficiently owing to improvement in reaction yields for O-alkylation.Type: ApplicationFiled: March 1, 2005Publication date: September 1, 2005Applicant: Terumo Kabushiki KaishaInventors: Masashi Isozaki, Tetsuro Kawanishi
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Patent number: 6228391Abstract: Novel amidine derivatives of the formula (1); and drug carriers such as liposomes or emulsions comprising the derivatives, which can enclose genetic materials or drugs and transfer them to cells or affected sites efficiently and safely, wherein A is an aromatic ring, R1 and R2 are the same or different and independently represent an alkyl group having any one of 10 to 25 carbon atoms, and an alkenyl group having any one of 10 to 25 carbon atoms, X and Y are the same or different and independently represent —O—, —S—, —COO—, —OCO—, —CONH—, or —NHCO—, m is 0 or 1, and n is 0 or a natural number of 1 to 6.Type: GrantFiled: December 10, 1998Date of Patent: May 8, 2001Assignee: Terumo Kabushiki KaishaInventors: Kazuhiro Shimizu, Masashi Isozaki, Kazunori Koiwai
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Patent number: 5374641Abstract: Illustrative examples of the N-(3-pyridylalkyl)sulfonamide derivative are represented by the following formulae [II] and [III]: ##STR1## The derivatives are available for a thromboxane A.sub.2 production inhibitor, a thromboxane A.sub.2 antagonist, a prostaglandin H.sub.2 antagonist, an anti-thrombus agent, a thrombus-preventing agent and an anti-allergy agent.Type: GrantFiled: February 24, 1992Date of Patent: December 20, 1994Assignee: Terumo Kabushiki KaishaInventors: Hiroyuki Ohnishi, Masazumi Miyakoshi, Masashi Isozaki, Masayuki Fujitake, deceased, Naoya Mikami, Ryohei Yanoshita, Harue Akasofu, Katsuyoshi Sugizaki, Nobuyuki Nakata
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Patent number: 5214053Abstract: Thiourea derivatives represented by the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a lower alkyl group, or R.sub.1 and R.sub.2 taken together represent a group having the formula --(CH.sub.2).sub.x --CHR.sub.3 --(CH.sub.2).sub.y -- in which R.sub.3 represents hydrogen or a lower alkyl group and x and y represent an integer of 0 to 2, respectively, A represents the formula --CH.dbd.CH-- or --CH.dbd.N--, 1 is 1 or 2, m represents an integer of 0 to 2 and n represents an integer of 1 to 5.The thiourea derivatives possess an antiulcer activity and an antimicrobial activity against Helicobacter pyroli and are useful as an antiulcer agent and an antimicrobial agent against Helicobacter pyroli.Type: GrantFiled: September 2, 1992Date of Patent: May 25, 1993Assignee: Terumo Kabushiki KaishaInventors: Keiichi Nakazawa, Masashi Isozaki, Shingo Koyama
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Patent number: 5190961Abstract: Thiourea derivatives represented by the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a lower alkyl group, or R.sub.1 or R.sub.2 taken together represent a group having the formula --(CH.sub.2).sub.m --in which m is 4 or 5, R.sub.3 represents a lower alkyl group or a cycloalkyl group or a group having the formula--(CH.sub.2).sub.l --R.sub.4 in which R.sub.4 is a phenyl, naphthyl, pyridyl, furyl or thienyl group optionally having 1-3 substituents selected from the group consisting of lower alkyl, lower alkoxy, phenoxy, lower alkylthio, hydroxy, halogen, nitro, cyano and trifluoromethyl, and l represents an integer of 0 to 2 and n represents an integer of 1 to 5 or a physiologically acceptable salt thereof.The compounds of the invention are useful as a therapeutic agent for peptic ulcers which is also effective on prevention of the recurrence after discontinuation of the administration due to the antimicrobial activity against Helicobacter pyroli.Type: GrantFiled: August 2, 1991Date of Patent: March 2, 1993Assignee: Terumo Kabushiki KaishaInventors: Hirokazu Hasegawa, Isamu Endo, Shingo Koyama, Masashi Isozaki, Yukari Yoshiyama, Shigenori Nozawa, Norio Arakawa
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Patent number: 5189189Abstract: [Object] A fatty acid-related polyunsaturated compound can be selectively purified using an industrially operable successive method under moderate conditions. [Content] A highly purified fatty acid-related polyunsaturated compound is obtained by a process comprising steps of forming a complex with silver on account of the high degree of unsaturation of the fatty acid-related polyunsaturated compound, isolating the complex from other fats on account of the hydrophilicity of the complex and then applying dissociating procedures to the complex to obtain the fatty acid-related polyunsaturated compound as a target substance on account of the hydrophobicity of the fatty acid-related polyunsaturated compound. As to the procedures for dissociation, addition of a dissociating agent and reduction of silver are disclosed. As to the dissociating agent, various compounds which produce insoluble composition with silver other then water are disclosed.Type: GrantFiled: April 23, 1991Date of Patent: February 23, 1993Assignees: Harima Chemicals, Inc., Sagami Chemical Research CenterInventors: Yoshihisa Misawa, Hisao Kondo, Tetsuya Tsutsumi, Masahiro Hayashi, Daisuke Sugimori, Yorishige Matsuba, Masashi Isozaki, Hiroharu Nishigaki, Kazunaga Yazawa, Kiyosi Kondo
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Patent number: 5037837Abstract: Novel phenoxypropylamine derivative having the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 represent a hydrogen atom, a hydroxy group, a lower alkyl group or a lower alkoxy group, and R.sub.3 and R.sub.4 represent a lower alkyl group, or R.sub.3 and R.sub.4 taken together represent a group having the formula (CH.sub.2).sub.m wherein m represents 4 or 5, and n represents an integer of from 2 to 6 or a pharmaceutically acceptable salt thereof.The compounds are useful as a 5-lipoxygenase inhibitor and an antiulcer agent.Type: GrantFiled: November 1, 1990Date of Patent: August 6, 1991Assignee: Terumo Kabushiki KaishaInventors: Yoshiyuki Shikata, Ryoichi Nanba, Isamu Endo, Masashi Isozaki, Tadashi Okumura, Masazumi Miyakoshi, Shingo Koyama