Patents by Inventor Masataka Morishita
Masataka Morishita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Treatment of psoriasis by administration of 4-carbamoyl-1-.beta.-D-ribofuranosylimidszolium-5-oleate
Patent number: 5462929Abstract: A composition for curing proliferative skin diseases containing 4-carbamoyl-1-.beta.-D-ribofuranosyl-imidazolium 5-olate (mizoribine) as an active ingredient. It has a potent activity of inhibiting the growth of keratinocytes and an improved effect of curing psoriasis, so that it is useful for curing proliferative skin diseases. Further it has only an extremely reduced toxicity, is highly safe, and can be administered for long and perorally.Type: GrantFiled: April 11, 1994Date of Patent: October 31, 1995Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Makoto Kawashima, Kazuhiro Nagano, Kazuyoshi Hori, Hiroaki Ishikawa, Masataka Morishita -
Patent number: 5292767Abstract: A compound of the formula [I] and pharmaceutically acceptable salts thereof; and a synthetic intermediate represented by the formula [II] and pharmaceutically acceptable salts thereof, ##STR1## wherein R 1 is hydrogen or lower alkyl;R 2 is hydrogen or a protective group of thiol;R 3 is hydroxy, a remainder of ester group or a remainder of amido group;A is straight or branched lower alkylene, andthe sulfur atom in the side chain may be directly join with --CO-- to conform a thiolactone ring.The compounds of this invention have excellent thymulin-like activities and are expected to be useful for treatment of various immune disorders such as immunodeficiency and autoimmune diseases.Type: GrantFiled: February 18, 1993Date of Patent: March 8, 1994Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Shiro Mita, Yoichi Kawashima, Nobuharu Kato, Hiroshi Suhara, Koji Yoneda, Masataka Morishita
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Patent number: 4873087Abstract: A preparation containing an absorption promoter selected from N-acyl amino acid derivatives or N-acyl peptide derivatives represented by the formula: R-CO-A (R is an aliphatic hydrocarbon group, an aromatic hydrocarbon group or an aryl-substituted lower hydrocarbon group which may optionally be substituted, and A is an amino acid residue or a peptide residue), preferably in the presence of a salt at a concentation exhibiting higher osmotic pressure than isotonic sodium chloride solution, and a medicine is found to promote absorption of the medicine through a gastrointestinal organ such as the colon and rectum, and through the vagina.Type: GrantFiled: March 8, 1982Date of Patent: October 10, 1989Assignee: Toyo Jozo Company, Ltd.Inventors: Masataka Morishita, Renji Aikawa, Shigeo Katsuragi, Yoshiaki Yamamoto, Kenichi Sugimoto
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Patent number: 4716153Abstract: Stable oral preparations of 16-membered ring macrolide antibiotics such as SF-837, josamycin, 3"-propionyljosamycin, by incorporating stabilizers showing pH 3-10 in an aqueous medium, such as glycine, and dissolution accelerators showing pH 2.5-4 in an aqueous medium such as citric acid or tartaric acid. Coating such dissolution accelerators with a film-forming substance is useful to enhance the stability of the oral preparation of such antibiotics.Type: GrantFiled: August 25, 1986Date of Patent: December 29, 1987Assignee: Toyo Jozo Company, Ltd.Inventors: Masataka Morishita, Masaru Ono, Yukio Sumita
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Patent number: 4696822Abstract: An insecticidal composition which contains microcapsules whose core substance is made of 20-85% by weight of an insecticidal ingredient of diazinon or chlorpyrifos and 50% or less by weight of a diluent and wall material made of 10-30% by weight of polycathionic water-soluble nitrogen-containing compound and 10% by weight or less of a hardener. The microcapsules may be mixed with coagulation-preventing agent of non-ionic surfactant and water-soluble thickener and then may be shaped into granules.Type: GrantFiled: June 21, 1985Date of Patent: September 29, 1987Assignee: Toyo Jozo Company, Ltd.Inventors: Takafumi Matsumura, Masataka Morishita
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Patent number: 4609640Abstract: A preparation containing an absorption promoter selected from specific classes of water-soluble macromolecular compounds having chelating activity, preferably in the presence of a salt at a concentration such that the composition exhibits higher osmotic pressure than isotonic sodium chloride solution, and a medicine is found to promote absorption of the medicine through a gastrointestinal organ such as the colon, rectum, or vagina.Type: GrantFiled: January 25, 1982Date of Patent: September 2, 1986Assignee: Toyo Jozo Company, Ltd.Inventors: Masataka Morishita, Renji Aikawa, Yoshiaki Yamamoto
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Patent number: 4135943Abstract: Selective adsorbents are prepared by dispersing powdery adsorbents in a composition for forming a crosslinked high molecular weight polymer, then dispersing in fine droplets the dispersion in a vehicle and performing crosslinking reaction to form a crosslinked polymer. The fine powders of adsorbents are enclosed within the crosslinked polymer and dispersed in three-dimensional spaces. Hydroxyl group containing polymeric substance and crosslinking agent or a monomer mixture of ethylenically unsaturated monomer and crosslinking monomer is used in said composition. The selective adsorbents can be useful in separation or purification of various organic compounds.Type: GrantFiled: April 5, 1976Date of Patent: January 23, 1979Assignee: Toyo Jozo Company, Ltd.Inventors: Masataka Morishita, Mitsuru Fukushima, Yoshihito Inaba
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Patent number: 4123381Abstract: A cellulose microcapsule having absorbing capacity, consisting of outer semipermeable barrier layer of cellulose and absorbent powders dispersed within inner cellulose gel matrix is prepared by dispersing adsorbent powders in a solution of cellulose dissolved in a solvent which is not adversely affected by the adsorbing capacity of adsorbent powders and capable of dissolving cellulose, then forming the dispersion into droplets and finally precipitating cellulose on the droplets. It is excellent in resistance to chemicals such as acids, alkalis or organic solvents and is useful for various purposes.Type: GrantFiled: February 8, 1977Date of Patent: October 31, 1978Assignees: Toyo Jozo Company, Ltd., Asahi Kasei Kogyo Kabushiki KaishaInventors: Masataka Morishita, Mitsuru Fukushima, Tutomu Sasagawa, Yoshihito Inaba, Yasuo Yokokawa, Satoshi Araragi, Narumi Yoshida, Hachiro Uchiyama
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Patent number: 4118336Abstract: A novel cellulose microcapsule having adsorbing capacity, consisting of outer semipermeable barrier layer of cellulose and adsorbent powders dispersed within inner cellulose gel matrix, is prepared by ester hydrolysis of a precursor microcapsule consisting of cellulose ester derivative and adsorbent powders. It is excellent in resistance to chemicals such as acids, alkalis or organic solvents and is useful for various purposes.Type: GrantFiled: December 15, 1976Date of Patent: October 3, 1978Assignees: Toyo Jozo Company, Ltd., Asahi Kasei Kogyo Kabushiki KaishaInventors: Masataka Morishita, Yasuo Yokokawa, Tokio Nishikawa, Masahiro Mishiro, Shigeyasu Ohashi, Mitsuru Fukushima, Yoshihito Inaba, Tetsuo Matsuda
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Patent number: 3960662Abstract: 7-Amino-cephem compounds are produced from 7-substituted-cephem compounds by the enzymatic action of microorganisms Comamonas sp. SY-77-1 FERM-P 2410 or Pseudomonas ovalis ATCC 950.Type: GrantFiled: January 23, 1975Date of Patent: June 1, 1976Assignee: Toyo Jozo Kabushiki KaishaInventors: Tetsuo Matsuda, Tsutomu Yamaguchi, Tadashiro Fujii, Kunio Matsumoto, Masataka Morishita, Mitsuru Fukushima, Yuzo Shibuya
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Patent number: 3960757Abstract: Encapsulated medicaments are prepared by dissolving a wall material for capsules in at least one organic solvent poorly miscible with water which has a boiling point of less than 100.degree.C., a vapor pressure higher than that of water and a dielectric constant of less than about 10, dissolving or dispersing in the resulting solution a medicament which is insoluble or slightly soluble in water, dispersing the resulting solution or dispersion to the form of fine drops in a liquid vehicle comprising an aqueous solution of a hydrophilic colloid or surface active agent, and then removing the organic solvent by evaporation.Type: GrantFiled: June 29, 1973Date of Patent: June 1, 1976Assignee: Toyo Jozo Co., Ltd.Inventors: Masataka Morishita, Yoshihito Inaba, Mitsuru Fukushima, Yoshinori Hattori, Sadami Kobari, Tetsuo Matsuda
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Patent number: 3953360Abstract: Selective adsorbing particles are prepared by dispersing activated charcoal in a hydrophilic solvent solution of a polymer capable of forming a semi-permeable film in a coagulating medium and then adding the dispersion dropwise into a coagulating bath. The selective adsorbing particles have adsorption capacity substantially the same as that of untreated activated charcoal. Separation of organic compounds is performed by a method wherein a solution containing a mixture of adsorptive organic compounds and non-adsorptive compounds is contacted with the selective adsorbing particles. The method is suitable for separation or purification of various organic compounds such as antibiotics, dyestuffs, nucleic acids, preteins or enzymes.Type: GrantFiled: March 19, 1974Date of Patent: April 27, 1976Assignee: Toyo Jozo Company, Ltd.Inventors: Masataka Morishita, Mitsuru Fukushima, Yoshihito Inaba
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Patent number: 3951859Abstract: A novel molecular sieving particle containing adsorbent powders dispersed in matrix of micro-porous polymer gels is prepared by dispersing adsorbent powders into a polymeric material solution dissolved in a solvent, then emulsifying the thus prepared dispersion into a vehicle having a boiling point higher than that of the solvent and finally removing the solvent by evaporation. This molecular sieving particle has excellent molecular sieving effect as well as excellent adsorption capacity, and applicable in various applications.Type: GrantFiled: December 28, 1973Date of Patent: April 20, 1976Assignee: Toyo Jozo Co., Ltd.Inventors: Yoshihito Inaba, Masataka Morishita, Mitsuru Fukushima
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Patent number: 3943063Abstract: Microcapsules are made by (a.) dispersing or dissolving a core substance in a film-forming polymer solution, (b.) emulsifying in fine droplets the resulting dispersion or solution in a vehicle which is poorly miscible with the solvent of the polymer solution and which doesn't dissolve said polymer to prepare an emulsion, and (c.) adding to the emulsion a non-solvent for the polymer wherein the non-solvent is miscible with the solvent, poorly miscible with the vehicle, and does not dissolve the polymer, whereby the solvent is removed by being absorbed by non-solvent emulsion droplets to precipitate the polymer film around the core substance.Type: GrantFiled: January 2, 1973Date of Patent: March 9, 1976Assignee: Toyo Jozo Company, Ltd.Inventors: Masataka Morishita, Yoshihito Inaba, Mitsuru Fukushima, Sadami Kobari, Akiho Nagata, Jinnosuke Abe