Abstract: A simulated road generation system (10) includes an acquisition unit (11), a detection unit (12), an estimation unit (13), and a generation unit (14). The acquisition unit (11) acquires an image indicating a surrounding of a vehicle, and position information of the vehicle. The detection unit (12) detects a demarcation line of a road from the image. The estimation unit (13) estimates, based on the position information of the vehicle and the demarcation line in the image, a road parameter including at least one of a number of lanes included in a predetermined region on a real space, a length of the lane, a width of the lane, and a curve curvature. The generation unit (14) generates a simulated road, based on the road parameter.

Abstract: The present invention provides a retrieval apparatus (10) including: a search condition acquisition unit (11) acquiring a search condition specifying a plurality of starting points; a selection unit (12) selecting, from among a plurality of preregistered facilities, one or a plurality of facilities to be one or a plurality of meeting places from the plurality of starting points, based on the plurality of starting points and a crowdedness state of a public transportation means; and a notification unit (13) notifying a facility selected as the meeting place to a user.

Abstract: Silica particles having a thiol group on a surface thereof, and satisfying the following conditions (a) to (c): (a) a particle diameter is 20 to 1,000 nm; (b) a density of the thiol group on the surface of the silica particles is 0.002 to 0.2 piece/nm2; and (c) a ratio (B/A) in terms of an amount B (piece/particle) of the thiol group existing on the surface of the silica particles to an amount A of sulfur elements in the silica particles (the number of sulfur elements derived from thiol per silica particle) is 0.10 to 0.60.

Abstract: A fluorescent labeling particle for detecting a target substance, containing a composite particle having a phase containing a magnetic material and a phase containing a fluorescent material, and a thermoresponsive polymer on a surface of the composite particle.

Abstract: A method of detecting a target substance, containing the steps of: incorporating labeling particles into a test liquid containing an analyte; heating the test liquid; irradiating the test liquid with excitation light, and detecting the target substance contained in the test liquid depending on a state of light emission of the labeling particles; wherein an aggregation state of the labeling particles is changed by the heating step; and wherein the labeling particles have a thermoresponsive polymer on a surface of a composite particle containing a magnetic material and a fluorescent material, and further have a biomolecule having properties of binding with the target substance.

Abstract: The purpose of the present invention is to provide: a method for detecting a substance of interest and a method for quantifying a substance of interest, whereby it becomes possible to detect or quantify the substance of interest properly using a reagent that can be produced with high yield; a kit; and a method for preparing a regent.

Abstract: Provided is a method by which the quantity of objects to be detected can be quickly determined with high sensitivity. The method of determining the quantity of objects to be detected in a specimen comprises: a mixing step for preparing a mixture by mixing the specimen and carrier particles that carry stimulus-responsive substances and a first affinity substance for the objects to be detected; a measurement step for placing the mixture under the condition that the stimulus-responsive substances aggregate, and measuring the particle diameter of a suspended solid in the mixture; and a determination step for determining, on the basis of the particle diameter, the quantity of the objects to be detected.

Abstract: A method of detecting a target substance, containing the steps of: incorporating labeling particles into a test liquid containing an analyte; heating the test liquid; irradiating the test liquid with excitation light, and detecting the target substance contained in the test liquid depending on a state of light emission of the labeling particles; wherein an aggregation state of the labeling particles is changed by the heating step; and wherein the labeling particles have a thermoresponsive polymer on a surface of a composite particle containing a magnetic material and a fluorescent material, and further have a biomolecule having properties of binding with the target substance.

Abstract: A fluorescent labeling particle for detecting a target substance, containing a composite particle having a phase containing a magnetic material and a phase containing a fluorescent material, and a thermoresponsive polymer on a surface of the composite particle.

Abstract: Silica particles having a thiol group on a surface thereof, and satisfying the following conditions (a) to (c): (a) a particle diameter is 20 to 1,000 nm; (b) a density of the thiol group on the surface of the silica particles is 0.002 to 0.2 piece/nm2; and (c) a ratio (B/A) in terms of an amount B (piece/particle) of the thiol group existing on the surface of the silica particles to an amount A of sulfur elements in the silica particles (the number of sulfur elements derived from thiol per silica particle) is 0.10 to 0.60.

Abstract: A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof to coexist with a linker molecule having a maleimido group and a carboxyl group in an aprotic solvent, thereby allowing formation of a thioether bond between the thiol group and the maleimido group, and obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded to coexist with carbodiimide and a biomolecule having an amino group in an aqueous solvent, thereby allowing formation of an amide bond between the carboxyl group active esterified by the carbodiimide, and the amino group of the biomolecule.

Abstract: A kit for immunochromatography, having: a planar test strip having a test area and a reference area, the test area having a test purpose capturing substance, the reference area having a reference purpose capturing substance; fluorescent particulates provided with a binding property to a target substance, the target substance provided with a binding property to the test purpose capturing substance; and light absorbing particulates provided with a binding property to the reference purpose capturing substance.

Abstract: A method of producing functional molecule-containing silica nanoparticles on which a biomolecule is bonded, containing the steps of: allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof to coexist with a linker molecule having a maleimido group and a carboxyl group in an aprotic solvent, thereby allowing formation of a thioether bond between the thiol group and the maleimido group, and obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded to coexist with carbodiimide and a biomolecule having an amino group in an aqueous solvent, thereby allowing formation of an amide bond between the carboxyl group active esterified by the carbodiimide, and the amino group of the biomolecule.