Patents by Inventor Masataka Ueno
Masataka Ueno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7563811Abstract: The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).Type: GrantFiled: July 6, 2005Date of Patent: July 21, 2009Assignee: Eisai R&D Management Co., Ltd.Inventors: Satoshi Nagato, Kohshi Ueno, Koki Kawano, Yoshihiko Norimine, Koichi Ito, Takahisa Hanada, Masataka Ueno, Hiroyuki Amino, Makoto Ogo, Shinji Hatakeyama, Yoshio Urawa, Hiroyuki Naka, Anthony John Groom, Leanne Rivers, Terence Smith
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Publication number: 20090087711Abstract: This invention provides an electrode for a fuel battery, which can improve both current collection properties and oxidizing gas and/or fuel feedability by allowing produced water to be more easily removed, and a cell for a fuel battery, and a stack for a fuel battery. The electrode for a fuel battery comprises a net material (51, 52), a microporous layer (MPL) (51b, 52b) formed integrally on one side of the net material (21, 22), and a catalyst layer (51c, 52c) formed integrally on one side of the net material (21, 22) closer to the surface. The net material (51, 52) is in a plate form and has an electrically conductive material plate (53) on its other side. The microporous layer (51b, 52b) has a number of interconnected micropores and, at the same time, is electrically conductive and repellent to water. The net material (51, 52) has a number of interconnected voids and, at the same time, is electrically conductive, and each void, together with the plate (53), constitutes an air chamber or a fuel chamber.Type: ApplicationFiled: October 31, 2006Publication date: April 2, 2009Applicant: KABUSHIKI KAISHA EQUOS RESEARCHInventors: Masataka Ueno, Hiroyuki Yamakawa, Hiroki Tsukamoto
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Publication number: 20090030017Abstract: The present invention relates to a therapeutic agent for dyskinesia excluding tremor, comprising 1,2-dihydropyridine compound, a salt thereof, or a solvate thereof, which shows AMPA receptor antagonism and is highly useful as a pharmaceutical drug.Type: ApplicationFiled: April 10, 2006Publication date: January 29, 2009Applicant: Eisai R & D Management Co., LtdInventors: Takahisa Hanada, Masataka Ueno, Sadako Kuno, Eiji Mizuta
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Patent number: 7153605Abstract: A fuel cell wherein efficient cooling is achieved by supplying air and cooling water simultaneously while maintaining cooling and wetting of a membrane without increasing the size of the fuel cell. The fuel cell includes a separator sandwiched between unit cells. The separator includes an air passage on a front surface side abutting at least on a cathode of the unit cell and cooling passages supplied with air and water on the rear side thereof to cool the unit cell with latent heat of evaporation of water by heat of the unit cell transmitted to the cooling space. Thereby, the unit cell is cooled via the separator and clogging of the air passages by water is prevented.Type: GrantFiled: August 8, 2002Date of Patent: December 26, 2006Assignee: Kabushikikaisha Equos ResearchInventors: Munehisa Horiguchi, Hidemi Kato, Masataka Ueno
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Publication number: 20060189622Abstract: The present invention provides a novel compound exhibiting an excellent inhibitory action on AMPA receptor and/or kainate receptor. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. In the formula, A1, A2 and A3 are independent of each other and each represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a 5- to 14-membered non-aromatic heterocyclic group, a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may be substituted; Q represents O, S or NH; Z represents C or N; X1, X2 and X3 are independent of each other and each represents a single bond, an optionally substituted C1-6 alkylene group, an optionally substituted C2-6 alkenylene group, an optionally substituted C2-6 alkynylene group, —NH—, —O—, —NHCO—, —CONH—, —SO0-2—, etc.Type: ApplicationFiled: April 21, 2006Publication date: August 24, 2006Inventors: Satoshi Nagato, Koki Kawano, Koichi Ito, Yoshihiko Norimine, Kohshi Ueno, Takahisa Hanada, Hiroyuki Amino, Makoto Ogo, Shinji Hatakeyama, Masataka Ueno, Anthony Groom, Leanne Rivers, Terence Smith
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Publication number: 20050245581Abstract: The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally sbutituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).Type: ApplicationFiled: July 6, 2005Publication date: November 3, 2005Inventors: Satoshi Nagato, Kohshi Ueno, Koki Kawano, Yoshihiko Norimine, Koichi Ito, Takahisa Hanada, Masataka Ueno, Hiroyuki Amino, Makoto Ogo, Shinji Hatakeyama, Yoshio Urawa, Hiroyuki Naka, Anthony Groom, Leanne Rivers, Terence Smith
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Patent number: 6949571Abstract: The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof. In the formula, Q indicates NH, O or S; and R1, R2, R3, R4 and R5 are the same as or different from each other and each indicates hydrogen atom, a halogen atom, a C1-6 alkyl group or a group represented by the formula —X-A (wherein X indicates a single bond, an optionally substituted C1-6 alkylene group etc.; and A indicates an optionally substituted C6-14 aromatic hydrocarbocyclic group or 5- to 14-membered aromatic heterocyclic group etc.).Type: GrantFiled: June 8, 2001Date of Patent: September 27, 2005Assignee: Eisai Co., Ltd.Inventors: Satoshi Nagato, Kohshi Ueno, Koki Kawano, Yoshihiko Norimine, Koichi Ito, Takahisa Hanada, Masataka Ueno, Hiroyuki Amino, Makoto Ogo, Shinji Hatakeyama, Anthony John Groom, Leanne Rivers, Terence Smith
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Patent number: 6896985Abstract: There is provided a fuel cell system which is efficient and does not cause reduction in output even when operation and stopping of a fuel cell are repeated for a long period of time. The fuel cell system is provided with a fuel cell stack including a fuel chamber for supplying a hydrogen gas to a hydrogen electrode and an oxygen chamber for supplying air to an oxygen electrode. The system is provided with gas supply ports for supplying the hydrogen gas into the fuel chamber, gas discharge ports for discharging the hydrogen gas from the fuel chamber, a hydrogen suction pump and the like for sucking the hydrogen gas from the gas discharge ports, a hydrogen circulation pipe and the like for interconnecting the gas discharge ports and the gas supply ports through the hydrogen suction pump and the like, and a first hydrogen discharge pipe and the like for interconnecting the gas discharge ports and an outside gas release port through the hydrogen suction pump and the like.Type: GrantFiled: August 28, 2002Date of Patent: May 24, 2005Assignee: Kabushiki Kaisha Equos ResearchInventors: Munehisa Horiguchi, Taizo Yamamoto, Masataka Ueno, Kenji Kato, Hideto Miyazaki
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Patent number: 6825192Abstract: The present invention provides a hetrodiazinon compound having 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonistic action, which is represented by the following formula (I), a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A represents O, S or a group represented by the formula NR3 (wherein R3 represents hydrogen atom or a lower alkyl group); R1 and R2 are the same as or different from each other and each represents an optionally substituted (hetero)aryl group etc.; and R4 and R5 are the same as or different from each other and each represents hydrogen atom, hydroxy, a halogen atom, nitrile group, nitro group, a lower alkyl group, a (hetero)aryl group etc.Type: GrantFiled: August 15, 2001Date of Patent: November 30, 2004Assignee: Eisai Co., Ltd.Inventors: Koichi Ito, Noritaka Kitazawa, Satoshi Nagato, Akiharu Kajiwara, Tatsuto Fukushima, Shinji Hatakeyama, Takahisa Hanada, Masataka Ueno, Kohshi Ueno, Koki Kawano
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Publication number: 20040023973Abstract: The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt thereof or hydrates thereof.Type: ApplicationFiled: November 26, 2002Publication date: February 5, 2004Inventors: Satoshi Nagato, Kohshi Ueno, Koki Kawano, Yoshihiko Norimine, Koichi Ito, Takahisa Hanada, Masataka Ueno, Hiroyuki Amino, Makoto Ogo, Shinji Hatakeyama, Yoshio Urawa, Hiroyuki Naka, Anthony John Groom, Leanne Rivers
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Publication number: 20030225081Abstract: The present invention provides a novel compound exhibiting an excellent inhibitory action on AMPA receptor and/or kainate receptor. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them.Type: ApplicationFiled: March 18, 2003Publication date: December 4, 2003Inventors: Satoshi Nagato, Koki Kawano, Koichi Ito, Yoshihiko Norimine, Koshi Ueno, Takahisa Hanada, Hiroyuki Amino, Makoto Ogo, Shinji Hatakeyama, Masataka Ueno, Anthony John Groom, Leanne Rivers, Terence Smith
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Publication number: 20030059656Abstract: There is provided a fuel cell system which is efficient and does not cause reduction in output even when operation and stopping of a fuel cell are repeated for a long period of time. The fuel cell system is provided with a fuel cell stack including a fuel chamber for supplying a hydrogen gas to a hydrogen electrode and an oxygen chamber for supplying air to an oxygen electrode. The system is provided with gas supply ports for supplying the hydrogen gas into the fuel chamber, gas discharge ports for discharging the hydrogen gas from the fuel chamber, a hydrogen suction pump and the like for sucking the hydrogen gas from the gas discharge ports, a hydrogen circulation pipe and the like for interconnecting the gas discharge ports and the gas supply ports through the hydrogen suction pump and the like, and a first hydrogen discharge pipe and the like for interconnecting the gas discharge ports and an outside gas release port through the hydrogen suction pump and the like.Type: ApplicationFiled: August 28, 2002Publication date: March 27, 2003Applicant: KABUSHIKI KAISHA EQUOS RESEARCHInventors: Munehisa Horiguchi, Taizo Yamamoto, Masataka Ueno, Kenji Kato, Hideto Miyazaki
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Publication number: 20030039875Abstract: The present invention is to provide an efficient cooling by supplying air and cooling water simultaneously while keeping cooling and wetting of a membrane without having a fuel cell large-sized. A fuel cell includes a separator 10B between unit cells 10A adjacent to each other. The separator includes an air pass S1 on a front surface side abutting at least on a cathode of the unit cell and it includes a cooling space S2 supplied with air and water on the rear side thereof to cool the unit cell with latent heat of water evaporated by heat of the unit cell transmitted to the cooling space. Thereby, the unit cell is cooled via the separator and clogging up of the air pass caused by water entering is prevented.Type: ApplicationFiled: August 8, 2002Publication date: February 27, 2003Inventors: Munehisa Horiguchi, Hidemi Kato, Masataka Ueno
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Patent number: 6511765Abstract: A fuel cell power generating apparatus includes a stack of a plurality of fuel cell units each having a cathode and an anode disposed on opposite sides of an electrolyte membrane. A fuel gas supply system supplies fuel gas to the anode, an air supply system supplies air to the cathode and a water supply system supplies liquid water to the cathode. A control unit ensures that, when the apparatus starts up, the cathode is first supplied with air, followed by supply of the liquid water. In a preferred embodiment, the water supply system intermittently sprays the liquid water onto the cathode when the temperature of the fuel cell stack monitored by a temperature sensor falls below a predetermined temperature.Type: GrantFiled: November 30, 2000Date of Patent: January 28, 2003Assignee: Kabusikikaisha Equos ResearchInventors: Masataka Ueno, Kenji Kato, Munehisa Horiguchi, Noriyuki Takada
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Patent number: 6294277Abstract: A fuel cell power generating apparatus includes a stack of a plurality of fuel cell units each having a cathode and an anode disposed on opposite sides of an electrolyte membrane. A fuel gas supply system supplies fuel gas to the anode, an air supply system supplies air to the cathode and a water supply system supplies liquid water to the cathode. A control unit ensures that, when the apparatus starts up, the cathode is first supplied with air, followed by supply of the liquid water. In a preferred embodiment, the water supply system intermittently sprays the liquid water onto the cathode when the temperature of the fuel cell stack monitored by a temperature sensor falls below a predetermined temperature.Type: GrantFiled: December 18, 1998Date of Patent: September 25, 2001Assignee: Kabushikikaisha Equos ResearchInventors: Masataka Ueno, Kenji Kato, Munehisa Horiguchi, Noriyuki Takada
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Patent number: 6281214Abstract: A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: wherein R1, R2, R3, R4, and R5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.Type: GrantFiled: October 5, 1998Date of Patent: August 28, 2001Assignee: Eisai Co., LtdInventors: Kozo Akasaka, Masahiro Yonaga, Akiharu Kajiwara, Kunizo Higurashi, Kohshi Ueno, Satoshi Nagato, Makoto Komatsu, Noritaka Kitazawa, Masataka Ueno, Yoshiharu Yamanishi, Yoshimasa Machida, Yuki Komatsu, Naoyuki Shimomura, Norio Minami, Toshikazu Shimizu, Atsushi Nagaoka
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Patent number: 6238814Abstract: A fuel cell power generating apparatus (1) using a fuel cell stack (2) includes an air intake manifold (45) mounted above the stack for supplying air to a plurality of longitudinally extending air flow passages of fuel cells in stack; one or more of nozzles (55) mounted to side walls of THE air intake manifold for injecting water into the air intake manifold; and water supply system (50) for supplying water to the nozzles. In a preferable embodiment, the nozzles are mounted respectively to a pair of opposite side walls of the air intake manifold at location offset to each other or at different angle of water injection, to facilitate complete dispersion or distribution of water over the entirety of the air intake manifold, which allows smooth entry of the sprayed water to the respective air flow passages of the fuel cells.Type: GrantFiled: December 18, 1998Date of Patent: May 29, 2001Assignee: KabushikiKaisha Equos ResearchInventors: Munehisa Horiguchi, Masataka Ueno, Noriyuki Takada
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Publication number: 20010001287Abstract: A fuel cell power generating apparatus (1) using a stack (2) of a plurality of fuel cell units (U) each having a structure such that a cathode (3) and an anode (4) are disposed on opposite sides of an electrolyte membrane (5) has a fuel gas supply system (10) that supplies fuel gas to the anode, an air supply system (40) that supplies air to the cathode and a water supply system (50) that supplies liquid water to the cathode. A control unit (151) controls such that, when the apparatus starts up, the cathode is first subjected to supply of the air, followed by supply of the liquid water. In a preferable embodiment, the water supply system is driven to intermittently spray the liquid water to the cathode when the temperature of the fuel cell stack monitored by a temperature sensor (47) becomes below a predetermined temperature.Type: ApplicationFiled: November 30, 2000Publication date: May 17, 2001Inventors: Masataka Ueno, Kenji Kato, Munehisa Horiguchi, Noriyuki Takada
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Patent number: 5853910Abstract: A fuel cell power generating apparatus using a fuel cell (10) having a structure such that a cathode and an anode are disposed on opposite sides of a polymer electrolyte membrane, comprising: an air introduction passage (11) for introducing air to the cathode; an air discharge passage (15) for discharging, to the outside of the system, discharge gas containing reactant water generated at the cathode; a circulation passage (16) connected between the air discharge passage and the air introduction passage in order to again introduce at least a portion of the discharge gas flowing through the air discharge passage to the air introduction passage and thus to the cathode; a valve (17) provided for at least one of the air introduction passage and the air discharge passage; a temperature sensor (22) for measuring the temperature of the discharge gas from the cathode; an ampere meter (19) for measuring the level of an electric current output from the fuel cell; and a control unit (18) for controlling the degree of opeType: GrantFiled: March 27, 1997Date of Patent: December 29, 1998Assignee: Kabushikikaisha Equos ResearchInventors: Norihiro Tomioka, Hiroehi Nakashima, Masataka Ueno, Koichi Shiraishi, Saki Izumisawa
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Patent number: 5849912Abstract: A biphenyl derivative represented by the following formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined in the specification, is clinically useful for treating and ameliorating mental disorders such as cerebrovascular disorder, aggressive behavior due to senile dementia, mental excitation, poriomania, delirium, hallucination, hyperkinesia, schizophrenia, emotional disturbance, depression, neurosis, psychophysiologic disorder and anxiety neurosis. The compounds exhibit dopamine 2 receptor antagonism and/or serotonin 2 receptor antagonism.Type: GrantFiled: May 12, 1997Date of Patent: December 15, 1998Assignee: Eisai Co., Ltd.Inventors: Kozo Akasaka, Masahiro Yonaga, Akiharu Kajiwara, Kunizo Higurashi, Kohshi Ueno, Satoshi Nagato, Makoto Komatsu, Noritaka Kitazawa, Masataka Ueno, Yoshiharu Yamanishi, Yoshimasa Machida, Yuki Komatsu, Naoyuki Shimomura, Norio Minami, Toshikazu Shimizu, Atsushi Nagaoka