Patents by Inventor Masato Horie
Masato Horie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100261880Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: ApplicationFiled: September 30, 2008Publication date: October 14, 2010Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: MASATO HORIE, KEIICHI OKUTOMI, YOSHIHIRO TANIGUCHI, MIKIO SUZUKI, YUTAKA OHBUCHI
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Publication number: 20100160611Abstract: The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.Type: ApplicationFiled: January 19, 2010Publication date: June 24, 2010Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Tsutomu FUJIWARA, Takeshi WANTANABE, Masato HORIE
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Patent number: 7678007Abstract: The present invention relates to a reclining device that includes an external teeth gear and an internal teeth gear and in which the rotation axis of one of the external teeth gear and the internal teeth gear revolves around the rotation axis of the other. The present invention aims to provide a reclining device of which the operation force is small and the operation force varies little. To achieve the aim, one of (a) the plane of each of the external teeth 31b that engages with the internal teeth 32b and (b) the plane of each of the internal teeth 32b that engages with the external teeth 31b is arranged to be flat, and the other of (a) and (b) is arranged to be convex.Type: GrantFiled: November 7, 2006Date of Patent: March 16, 2010Assignee: Shiroki Kogyo Co., LtdInventors: Masato Horie, Yoichi Takada
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Patent number: 7674889Abstract: The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.Type: GrantFiled: November 7, 2006Date of Patent: March 9, 2010Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Tsutomu Fujiwara, Takeshi Watanabe, Masato Horie
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Publication number: 20100048878Abstract: The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.Type: ApplicationFiled: July 27, 2009Publication date: February 25, 2010Applicant: Otsuka Pharmaceutical Co., Ltd.Inventors: Tsutomu Fujiwara, Takeshi Watanabe, Masato Horie
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Publication number: 20090297888Abstract: A magnetic recording medium substrate has a polyester film having metallic oxide-containing layers (layers M) formed on both the surfaces, one layer on each surface, the layers M having a thickness of 50 to 200 nm each, characterized in that the magnetic recording medium substrate has a total light transmittance of 0 to 75% and a surface resistivity of 1×102 to 1×1013? on each surface.Type: ApplicationFiled: September 21, 2006Publication date: December 3, 2009Inventors: Masato Horie, Makoto Sato, Takuji Higashioji, Yukari Nakamori, Hiroaki Watanabe
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Patent number: 7592438Abstract: The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.Type: GrantFiled: July 6, 2007Date of Patent: September 22, 2009Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Tsutomu Fujiwara, Takeshi Watanabe, Masato Horie
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Patent number: 7582732Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: GrantFiled: July 3, 2008Date of Patent: September 1, 2009Assignee: Osaka Pharmaceutical Co., Ltd.Inventors: Masato Horie, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi
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Publication number: 20090017479Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: ApplicationFiled: February 15, 2008Publication date: January 15, 2009Inventors: Masato HORIE, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi
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Publication number: 20080275218Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SEQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: ApplicationFiled: July 3, 2008Publication date: November 6, 2008Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Masato HORIE, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi
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Patent number: 7432363Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: GrantFiled: December 23, 2003Date of Patent: October 7, 2008Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Masato Horie, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi
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Patent number: 7420048Abstract: An isolated and purified human skeletal muscle-specific ubiquitin-conjugating enzyme comprising the amino acid sequence shown in SEQ ID NO: 22 is disclosed. The use of the genes make it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.Type: GrantFiled: January 15, 2003Date of Patent: September 2, 2008Assignee: Otsuka Pharmaceutical Co., Ltd.Inventors: Tsutomu Fujiwara, Takeshi Watanabe, Masato Horie
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Publication number: 20080032337Abstract: The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.Type: ApplicationFiled: July 6, 2007Publication date: February 7, 2008Inventors: Tsutomu FUJIWARA, Takeshi Watanabe, Masato Horie
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Publication number: 20070295161Abstract: The present invention relates to a reclining device that includes an external teeth gear and an internal teeth gear and in which the rotation axis of one of the external teeth gear and the internal teeth gear revolves around the rotation axis of the other, the external teeth gear having external teeth on the outer circumferential surface thereof and being disposed with one of a member on the seat cushion side and a member on the seat back side, and the internal teeth gear having internal teeth of which the number of teeth is larger than that of the external teeth of the external teeth gear and that are configured so as to engage with the external teeth and being disposed with the other of the member on the seat cushion side and the member on the seat back side. The present invention aims to provide a reclining device of which the operation force is small and the operation force varies little.Type: ApplicationFiled: November 7, 2006Publication date: December 27, 2007Inventors: Masato Horie, Yoichi Takada
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Patent number: 7235253Abstract: A method is disclosed for stabilizing a physiologically active peptide in a process of preparing a powder containing the physiologically active peptide by drying an aqueous liquid containing the physiologically active peptide, wherein the method comprises adding to the aqueous liquid at least one compound selected from the group consisting of a nonionic surfactant, a water-soluble, nonionic, organic binder, hydrogenated lecithin, and mannitol.Type: GrantFiled: November 28, 2001Date of Patent: June 26, 2007Assignee: JCR Pharmaceuticals Co., Ltd.Inventors: Yoshinobu Hanyu, Mariko Okada, Chihiro Shindo, Satoshi Nishimuro, Tetsuo Yokoyama, Masato Horie
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Publication number: 20070111285Abstract: The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.Type: ApplicationFiled: November 7, 2006Publication date: May 17, 2007Inventors: Tsutomu Fujiwara, Takeshi Watanabe, Masato Horie
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Publication number: 20060134634Abstract: The present invention provides novel human genes, for example a novel human gene comprising a nucleotide sequence coding for the amino acid sequence shown under SEQ ID NO:1. The use of the genes makes it possible to detect the expression of the same in various tissues, analyze their structures and functions, and produce the human proteins encoded by the genes by the technology of genetic engineering. Through these, it becomes possible to analyze the corresponding expression products, elucidate the pathology of diseases associated with the genes, for example hereditary diseases and cancer, and diagnose and treat such diseases.Type: ApplicationFiled: February 20, 2004Publication date: June 22, 2006Inventor: Masato Horie
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Patent number: 7025419Abstract: A seat mechanism for vehicle includes a lower rail fixed to a vehicle floor; an upper member having an upper rail guided by the lower rail; a seat back pivoted on the upper member and movable between upright and forward-tilted positions; a slide lock mechanism for locking the upper member relative to the lower rail; a slide-position memory mechanism for remembering an adjusted position of the upper rail relative to the lower rail after the seat back has moved to the forward-tilted position; and a forward-tilt holding mechanism for holding the seat back in the forward-tilted position. The forward-tilt holding mechanism includes engaging members which engage when the seat back is in the forward-tilted position, and disengage when the seat back is in the upright position, the forward-tilt holding mechanism providing a resistance force during a returning operation of the seat back to the upright position.Type: GrantFiled: May 12, 2004Date of Patent: April 11, 2006Assignee: Shiroki CorporationInventors: Kazutaka Sasaki, Hidehiko Fujioka, Masato Horie
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Publication number: 20040262969Abstract: A seat mechanism for vehicle includes a lower rail fixed to a vehicle floor; an upper member having an upper rail guided by the lower rail; a seat back pivoted on the upper member and movable between upright and forward-tilted positions; a slide lock mechanism for locking the upper member relative to the lower rail; a slide-position memory mechanism for remembering an adjusted position of the upper rail relative to the lower rail after the seat back has moved to the forward-tilted position; and a forward-tilt holding mechanism for holding the seat back in the forward-tilted position. The forward-tilt holding mechanism includes engaging members which engage when the seat back is in the forward-tilted position, and disengage when the seat back is in the upright position, the forward-tilt holding mechanism providing a resistance force during a returning operation of the seat back to the upright position.Type: ApplicationFiled: May 12, 2004Publication date: December 30, 2004Inventors: Kazutaka Sasaki, Hidehiko Fujioka, Masato Horie
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Publication number: 20040254340Abstract: The invention provides a brain-specific gene useful in treating Alzheimer's disease, for instance, which comprises a nucleotide sequence cording for the amino acid sequence shown in SQ ID NO:1 and fragments thereof; an expression vector comprising the gene; a host cell comprising the expression vector; an expression product of the gene; an antibody against the product; a therapeutic and prophylactic composition for neurodegenerative disease; and the like.Type: ApplicationFiled: December 23, 2003Publication date: December 16, 2004Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Masato Horie, Keiichi Okutomi, Yoshihiro Taniguchi, Mikio Suzuki, Yutaka Ohbuchi