Patents by Inventor Masato Kusunoki
Masato Kusunoki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220022851Abstract: The present invention provides a method for determining the likelihood of colorectal cancer development in a human ulcerative colitis patient, the method including: a measurement step of measuring methylation rates of one or more CpG sites present in specific differentially methylated regions in DNA recovered from a biological sample collected from the human ulcerative colitis patient; and a determination step of determining the likelihood of colorectal cancer development in the human ulcerative colitis patient based on average methylation rates of the differentially methylated regions which are calculated based on the methylation rates measured in the measurement step and a preset reference value or a preset multivariate discrimination expression, in which the reference value is a value for identifying a cancerous ulcerative colitis patient and a non-cancerous ulcerative colitis patient, which is set for the methylation rate of each differentially methylated region, and the multivariate discrimination expresType: ApplicationFiled: October 13, 2021Publication date: January 27, 2022Applicants: Hanumat Co., Ltd., EA Pharma Co., Ltd.Inventors: Masato KUSUNOKI, Yuji TOIYAMA, Koji TANAKA, Toshimitsu ARAKI, Akira MITSUI, Kenji TAKEHANA, Tsutomu UMEZAWA
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Publication number: 20190352721Abstract: The present invention provides a method for determining the likelihood of sporadic colorectal cancer development, the method including: a measurement step of measuring methylation rates of one or more CpG sites present in specific differentially methylated regions, in DNA recovered from a biological sample collected from a human subject; and a determination step of determining the likelihood of sporadic colorectal cancer development in the human subject, based on average methylation rates of the differentially methylated regions which are calculated based on the methylation rates measured and a preset reference value or a preset multivariate discrimination expression, in which the reference value is a value for identifying a sporadic colorectal cancer patient and a non-sporadic colorectal cancer patient, which is set for the average methylation rate of each differentially methylated region, and the multivariate discrimination expression includes, as variables, average methylation rates of one or more differenType: ApplicationFiled: September 28, 2017Publication date: November 21, 2019Applicants: Hanumat Co., Ltd., EA Pharma Co., Ltd.Inventors: Masato KUSUNOKI, Yuji TOIYAMA, Akira MITSUI, Kenji TAKEHANA, Tsutomu UMEZAWA
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Publication number: 20190241970Abstract: The present invention provides a method for determining the likelihood of colorectal cancer development in a human ulcerative colitis patient, the method including: a measurement step of measuring methylation rates of one or more CpG sites present in specific differentially methylated regions in DNA recovered from a biological sample collected from the human ulcerative colitis patient; and a determination step of determining the likelihood of colorectal cancer development in the human ulcerative colitis patient based on average methylation rates of the differentially methylated regions which are calculated based on the methylation rates measured in the measurement step and a preset reference value or a preset multivariate discrimination expression, in which the reference value is a value for identifying a cancerous ulcerative colitis patient and a non-cancerous ulcerative colitis patient, which is set for the methylation rate of each differentially methylated region, and the multivariate discrimination expresType: ApplicationFiled: July 7, 2017Publication date: August 8, 2019Applicants: Hanumat Co., Ltd., EA Pharma Co., Ltd.Inventors: Masato KUSUNOKI, Yuji TOIYAMA, Koji TANAKA, Toshimitsu ARAKI, Akira MITSUI, Kenji TAKEHANA, Tsutomu UMEZAWA
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Patent number: 9526735Abstract: An object of the present invention is to provide a method for suppressing surgical site infections (SSI) that have occurred at extremely high incidence rates at the time of surgical operations and particularly surgical operations on digestive system organs, and to provide a column to be used for the method. According to the present invention, a method is provided for suppressing surgical site infections, which comprises the steps of: (a) administering a chemotherapeutic drug for treating and/or preventing a surgical site infection; and (b) collecting blood from a surgical subject and removing leukocytes that comprise neutrophils from the blood during or within 24 hours after surgical operation, and then returning the blood from which the leukocytes have been removed to the surgical subject.Type: GrantFiled: March 7, 2014Date of Patent: December 27, 2016Assignee: ASAHI KASEI MEDICAL CO., LTD.Inventors: Masato Kusunoki, Chikao Miki, Shigeyuki Yoshiyama
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Publication number: 20140179659Abstract: An object of the present invention is to provide a method for suppressing surgical site infections (SSI) that have occurred at extremely high incidence rates at the time of surgical operations and particularly surgical operations on digestive system organs, and to provide a column to be used for the method. According to the present invention, a method is provided for suppressing surgical site infections, which comprises the steps of: (a) administering a chemotherapeutic drug for treating and/or preventing a surgical site infection; and (b) collecting blood from a surgical subject and removing leukocytes that comprise neutrophils from the blood during or within 24 hours after surgical operation, and then returning the blood from which the leukocytes have been removed to the surgical subject.Type: ApplicationFiled: March 7, 2014Publication date: June 26, 2014Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Masato KUSUNOKI, Chikao MIKI, Shigeyuki YOSHIYAMA
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Patent number: 8708945Abstract: An object of the present invention is to provide a method for suppressing surgical site infections (SSI) that have occurred at extremely high incidence rates at the time of surgical operations and particularly surgical operations on digestive system organs, and to provide a column to be used for the method. According to the present invention, a method is provided for suppressing surgical site infections, which comprises the steps of: (a) administering a chemotherapeutic drug for treating and/or preventing a surgical site infection; and (b) collecting blood from a surgical subject and removing leukocytes that comprise neutrophils from the blood during or within 24 hours after surgical operation, and then returning the blood from which the leukocytes have been removed to the surgical subject.Type: GrantFiled: June 23, 2005Date of Patent: April 29, 2014Assignee: Asahi Kasei Medical Co., Ltd.Inventors: Masato Kusunoki, Chikao Miki, Shigeyuki Yoshiyama
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Publication number: 20080260710Abstract: An object of the present invention is to provide a method for suppressing surgical site infections (SSI) that have occurred at extremely high incidence rates at the time of surgical operations and particularly surgical operations on digestive system organs, and to provide a column to be used for the method. According to the present invention, a method is provided for suppressing surgical site infections, which comprises the steps of: (a) administering a chemotherapeutic drug for treating and/or preventing a surgical site infection; and (b) collecting blood from a surgical subject and removing leukocytes that comprise neutrophils from the blood during or within 24 hours after surgical operation, and then returning the blood from which the leukocytes have been removed to the surgical subject.Type: ApplicationFiled: June 23, 2005Publication date: October 23, 2008Applicant: ASAHI KASEI MEDICAL CO., LTD.Inventors: Masato Kusunoki, Chikao Miki, Shigeyuki Yoshiyama
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Patent number: 6303583Abstract: A method of treating intestinal cancer characterized by performing an adjuvant therapy comprising continuous injection of 5FU and oral administration of UFT in combination with the injection after surgical resection of a human intestinal cancer.Type: GrantFiled: September 21, 1999Date of Patent: October 16, 2001Assignees: Taiho Pharmaceutical Company, LimitedInventor: Masato Kusunoki
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Patent number: D736913Type: GrantFiled: June 11, 2013Date of Patent: August 18, 2015Assignees: OTSUKA PHARMACEUTICAL FACTORY, INC., HANUMAT, LTD.Inventors: Masato Kusunoki, Takanori Inoue