Abstract: A cell culturing system is equipped with a cell culturing device and a support device. The cell culturing device comprises a culturing unit and a sampling unit. The support device includes a housing and a sampling support unit. The housing includes an accommodation chamber in which the culturing unit is accommodated. A sampling circuit unit is capable of being attached to and detached from the sampling support unit. The sampling support unit is installed on the outer surface of the housing.

Abstract: A cell culturing system includes a cell culturing device and a support device. The cell culturing device cultures cells by allowing a culture medium inside circulation flow paths connected to the bioreactor to flow inside the bioreactor. The cell culturing device is connected to the circulation flow paths and includes a waste liquid flow path in order to discard the liquid flowing through the circulation flow paths, and a waste liquid accommodation unit in which the liquid guided from the waste liquid flow path is accommodated. A sampling unit, in which the culture medium that is guided from the circulation flow paths to the waste liquid flow path is collected, is connected to the waste liquid flow path.

Abstract: Provided is a blood component collection cassette capable of measuring a circuit internal pressure using a simple and economical configuration. A blood component collection cassette includes an inflow line for sending blood or a blood component collected from a donor to a centrifugal separator, a return line for returning a predetermined blood component to the donor, and a line forming member forming one of the inflow line and the return line and having a load detection soft portion made of a soft material.

Abstract: In a blood transfusion system (a blood transfusion kit, a blood transfusion kit for emergency blood transfusion, or a method of using a blood transfusion kit), a flow path through which blood flows is formed using a tube having a channel therein. The flow path includes: a first path that connects an upstream path and a downstream path and has a leukocyte removal filter removing leukocytes at an intermediate position of the channel and a second path that connects the upstream path and the downstream path and bypasses the leukocyte removal filter.

Abstract: A blood component collection cassette that can trap a foreign object such as a blood-coagulated clot from blood components to be returned to a blood donor and a manufacturing method of the blood component collection cassette are provided. A sheet-shaped filter member (60) is arranged on a flow path (42) in a cassette main body (40) of a blood component collection cassette (28). A first tube (66) and a second tube (68) are arranged in the cassette main body (40). An inner space (51) of a filter housing unit (54a) is separated by the filter member (60) into a first space (51a) on the side of the first tube (66) and a second space (51b) on the side of the second tube (68).

Abstract: A blood component collection cassette has a flow path in the interior thereof through which blood flows, and a cassette main body composed of a resin that possesses flexibility. The cassette main body includes a first constituent part in which a plurality of concavities and convexities are formed. Furthermore, a resin sheet includes a second constituent part, which is provided on one portion of an outer surface of the flow path wall portion that constitutes the flow path, and in which the plurality of concavities and convexities do not exist.

Abstract: A flow path is formed in a cassette body of a blood component collection cassette. The cassette body includes a bulging structure in which at least a portion of the flow path is formed. A first gripped member, which is configured to be gripped by a first gripping member provided on a centrifugal separation device, is disposed on one surface of the bulging structure in a thickness direction thereof. A second gripped member, which is configured to be gripped by a second gripping member to which a load detection unit that is provided on the centrifugal separation device is fixed, is disposed on another surface of the bulging structure in the thickness direction thereof.

Abstract: A cell culturing system includes a processing unit that cultures cells, a reactor installation device in which the processing unit is installable, a connection circuit connected to the processing unit, a circuit control device to and from which the connection circuit is attachable and detachable, and a tank device including a culture medium accommodation unit for accommodating the culture medium. The processing unit includes a plurality of bioreactors. The culture medium in the culture medium accommodation unit is supplied to the processing unit via the connection circuit. The culture medium accommodation unit is capable of accommodating the culture medium of an amount required for culturing the cells in the processing unit.

Abstract: A cell culturing system includes a sampling channel, a detection unit, and a first measuring instrument that measures a gas component contained in a sample by means of the detection unit while the sample flows. The sampling device also includes a standard solution storage unit capable of supplying a standard solution to the detection unit through the sampling channel, and a gas supply device that supplies a gas having a predetermined component amount to the standard solution in the standard solution storage unit. The first measuring instrument performs calibration by measuring the standard solution mixed with the gas having the predetermined component amount.

Abstract: A cell culturing system includes a reactor, a flow channel that allows a culture medium to flow into and out of the reactor, a waste liquid channel that discharges the culture medium from the flow channel, and a waste liquid container capable of storing the culture medium passing through the waste liquid channel. The waste liquid channel includes a temporary storage unit capable of temporarily storing the culture medium. The waste liquid container is located below the temporary storage unit) in a gravity direction, and the temporary storage unit is provided above the flow channel in the gravity direction. The temporary storage unit temporarily stores the culture medium discharged from the flow channel and allows the culture medium to flow out toward the waste liquid container.

Abstract: A sampling device includes a sampling channel, a detection unit and a sample introduction channel. A cell culturing device or the sample introduction channel includes an aseptic filter in a section before the sampling channel. A sampling method includes a sampling step for introducing the sample from the culturing device and detecting the sample by the detection unit and an adhering substance removal step for removing an adhering substance adhering to the aseptic filter by allowing a fluid to flow from the sampling channel to the sample introduction channel.

Abstract: A blood component collection cassette of a blood component collection system, which is a biological component transfer system, includes a sheet-shaped cassette main body in which a blood line is formed. The blood line includes a second applied load measurement unit and line main body portions. A separation device includes a second load measurement unit that measures a load applied to a wall portion of the second applied load measurement unit in a cassette mounted state. The second applied load measurement unit is more easily deformed than the line main body portions, and is disposed at a location within the blood line on which only a positive pressure acts.

Abstract: A cell culturing system includes a processing unit that performs culturing of cells, a reactor installation device in which the processing unit is capable of being installed, a connection circuit that is connected to the processing unit, and a circuit control device to which the connection circuit is capable of being attached to and detached from and that is capable of supplying the cells and a culture medium from the connection circuit to the processing unit, and to receive a collection of cultured cells from the processing unit into the connection circuit. The processing unit includes a plurality of bioreactors. The reactor installation device is disposed separately with respect to the circuit control device.

Abstract: A cell culturing system configured to move a liquid sample from a cell culturing device to a sampling channel via a sample introduction channel. The sampling device includes a sampling channel having a main-mechanism-side pump disposed between a cleaning solution storage unit and the sample introduction channel and is configured to allow a cleaning solution to flow to a detection unit. The sample introduction channel includes an introduction-mechanism-side pump that is configured to allow the sample to flow from the sample introduction channel to the detection unit.

Abstract: A cell culturing system is equipped with a plurality of processing units that perform culturing of cells, a plurality of reactor installation devices in which the plurality of processing units are capable of being respectively installed, a plurality of connection circuits connected respectively to the plurality of processing units, a plurality of circuit control devices which the plurality of connection circuits are capable of being respectively attached to and detached from, and a sensor device. The sensor device is used in common with respect to the plurality of processing units in order to measure components of the culture medium guided into the plurality of processing units. Each of the plurality of processing units includes a plurality of bioreactors.

Abstract: A sampling method includes: a sampling step of circulating a sample from a cell culture device to a sampling channel and measuring concentrations of predetermined components in the sample by a second sensor and a gas concentration sensor; a cleaning step of circulating a cleaning liquid through the sampling channel to circulate the cleaning liquid through the second sensor and the gas concentration sensor after the sampling step; and an air introduction step of replacing the cleaning liquid remaining in the gas concentration sensor with air after the cleaning step.

Abstract: A cell culturing system includes a culturing device including a plurality of reactors, and a sampling device that receives a liquid sample from the culturing device. A sample introduction channel fluidically connects the cell culturing device and the sampling device. The sample introduce channel includes a temporary storage unit that can temporarily store a sample. A sample in each of the plurality of reactors may flows into the temporary storage unit under the operation of a pump. A combined sample may be obtained by combining the plurality of samples received from the plurality of reactors. The temporary storage unit sends the combined sample to a sampling channel of the sampling device.

Abstract: A sampling method includes a sampling step and a cleaning step. The sampling step includes a first sample introduction step of introducing a first sample from a first cell culturing device to a more downstream side than a first connection portion in a sampling flow path, a first returning step of causing the first sample in the sampling flow path to flow into an introduction path from the first connection portion after the first sample introduction step, and a first flowing step of bringing the first sample into contact with a second sensor after the first returning step.

Abstract: A cell culturing system is equipped with a reactor, a flow path through which a culture medium flows into and flows out from the reactor, an optical measurement unit that optically measures cells contained in the culture medium, and a control unit that processes measurement results of the optical measurement unit. The optical measurement unit includes, at different positions in a flow direction of the culture medium, a first measurement unit that performs optical measurements based on emission of a first measurement light, and a second measurement unit that performs optical measurements based on emission of a second measurement light. In addition, a first optical path length of the first measurement light is set to be longer than a second optical path length of the second measurement light.

Abstract: A sampling system includes a sensor (for example, a biosensor) that is provided in a sampling channel so as to be in contact with a sample and measures concentrations of predetermined components in the sample, an introduction path that introduces a cleaning liquid to an upstream side of the sensor of the sampling channel, and an air introduction path that is connected to the introduction path and is opened to the atmosphere. The air guided from the air introduction path flows into the sampling channel via the introduction path.