Patents by Inventor Masayoshi Fukuoka

Masayoshi Fukuoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10259792
    Abstract: The present invention provides a crystal that has preferable oral absorption and can be obtained with particularly preferable reproducibility. Provided is a crystal of (R)—N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: April 16, 2019
    Assignee: TAIHO PHARMACEUTICAL CO., LTD.
    Inventor: Masayoshi Fukuoka
  • Publication number: 20180134666
    Abstract: The present invention provides a crystal that has preferable oral absorption and can be obtained with particularly preferable reproducibility. Provided is a crystal of (R)—N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide.
    Type: Application
    Filed: April 28, 2016
    Publication date: May 17, 2018
    Applicant: TAIHO PHARMACEUTICAL CO., LTD.
    Inventor: Masayoshi FUKUOKA
  • Patent number: 8883759
    Abstract: There is provided an agent for potentiating the effects of an anti-tumor agent. An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents a C1-5 alkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom; R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a hydrogen atom or a halogen atom; and R3 represents a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a (C3-6 cycloalkyl) C1-6 alkyl group, a halogeno-C1-6 alkyl group or a saturated heterocyclic group.
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: November 11, 2014
    Assignee: Taiho Pharmaceutical Co., Ltd.
    Inventors: Masayoshi Fukuoka, Tatsushi Yokogawa, Seiji Miyahara, Hitoshi Miyakoshi, Wakako Yano, Junko Taguchi, Yayoi Takao
  • Patent number: 8530490
    Abstract: Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug. A uracil compound represented by the general formula (I) or a salt thereof: wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents —SO2NR1R2 or —NR3SO2—R4, wherein R1 and R2 each represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; R3 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R4 represents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: September 10, 2013
    Assignee: Taiho Pharmaceutical Co., Ltd.
    Inventors: Masayoshi Fukuoka, Tatsushi Yokogawa, Seiji Miyahara, Hitoshi Miyakoshi, Wakako Yano, Junko Taguchi, Yayoi Takao
  • Publication number: 20120225838
    Abstract: There is provided an agent for potentiating the effects of an anti-tumor agent. An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents a C1-5 alkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom; R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a hydrogen atom or a halogen atom; and R3 represents a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a (C3-6 cycloalkyl) C1-6 alkyl group, a halogeno-C1-6 alkyl group or a saturated heterocyclic group.
    Type: Application
    Filed: November 29, 2010
    Publication date: September 6, 2012
    Applicant: Taiho Pharmaceutical Co., Ltd.
    Inventors: Masayoshi Fukuoka, Tatsushi Yokogawa, Seiji Miyahara, Hitoshi Miyakoshi, Wakako Yano, Junko Taguchi, Yayoi Takao
  • Publication number: 20110082163
    Abstract: Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug. A uracil compound represented by the general formula (I) or a salt thereof: wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents —SO2NR1R2 or —NR3SO2—R4, wherein R1 and R2 each represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; R3 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R4 represents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like.
    Type: Application
    Filed: June 2, 2009
    Publication date: April 7, 2011
    Applicant: Taiho Pharmaceutical Co., Ltd.
    Inventors: Masayoshi Fukuoka, Tatsushi Yokogawa, Seiji Miyahara, Hitoshi Miyakoshi, Wakako Yano, Junko Taguchi, Yayoi Takao
  • Patent number: 5468141
    Abstract: A mold for injection molding of a thermoplastic resin. The mold comprises a cavity block, a core block, and a cavity formed between the cavity block and the core block and adapted to be filled with a molten resin. The cavity block includes an insulating layer on a cavity side thereof, the insulating layer being made of a material selected from the group consisting of ceramic materials, porcelain enamel, glass materials, heat resistant plastic materials and their composites. The core block includes a release insulating layer on a cavity side thereof, the release insulating layer being made of a material selected from the group consisting of fluorocarbon resins, fluorocarbon resin composite materials, silicone resin composite materials and metal platings with fluorocarbon resin dispersion, the release insulating layer further being adapted to effect both mold releasing and heat insulation.
    Type: Grant
    Filed: January 18, 1994
    Date of Patent: November 21, 1995
    Assignee: Taiyo Manufacturing Works Co., Ltd.
    Inventors: Hiroyuki Iwami, Masayoshi Fukuoka, Hiroyuki Kanayama
  • Patent number: 5223218
    Abstract: An instrument for quantitative analysis includes two shutters, one of which prevents light from being introduced into a black box housing a cell holder from the outside through a port in which a cell may be placed in and taken out the black box, and the other of which prevents light from impinging on a photomultiplier tube which is in communication with the black box. The shutters are controlled by a control unit so that one of the shutters opens when the other closes. The instrument also includes detectors which detect whether or not the cell holder and the cell are disposed at predetermined positions, respectively. The detectors output signals to the control unit. The control unit controls an automatic pipetting device to restrict a sample from being introduced into the cell when both the cell holder and the cell are not disposed at the predetermined position.
    Type: Grant
    Filed: April 8, 1988
    Date of Patent: June 29, 1993
    Assignee: Kabushiki Kaisha Meidensha
    Inventors: Masayoshi Fukuoka, Akira Matsuyuki