Patents by Inventor Masayoshi Fukuoka
Masayoshi Fukuoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10259792Abstract: The present invention provides a crystal that has preferable oral absorption and can be obtained with particularly preferable reproducibility. Provided is a crystal of (R)—N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide.Type: GrantFiled: April 28, 2016Date of Patent: April 16, 2019Assignee: TAIHO PHARMACEUTICAL CO., LTD.Inventor: Masayoshi Fukuoka
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Publication number: 20180134666Abstract: The present invention provides a crystal that has preferable oral absorption and can be obtained with particularly preferable reproducibility. Provided is a crystal of (R)—N-(1-(3-(cyclopentyloxy)phenyl)ethyl)-3-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)propane-1-sulfonamide.Type: ApplicationFiled: April 28, 2016Publication date: May 17, 2018Applicant: TAIHO PHARMACEUTICAL CO., LTD.Inventor: Masayoshi FUKUOKA
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Patent number: 8883759Abstract: There is provided an agent for potentiating the effects of an anti-tumor agent. An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents a C1-5 alkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom; R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a hydrogen atom or a halogen atom; and R3 represents a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a (C3-6 cycloalkyl) C1-6 alkyl group, a halogeno-C1-6 alkyl group or a saturated heterocyclic group.Type: GrantFiled: November 29, 2010Date of Patent: November 11, 2014Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Masayoshi Fukuoka, Tatsushi Yokogawa, Seiji Miyahara, Hitoshi Miyakoshi, Wakako Yano, Junko Taguchi, Yayoi Takao
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Patent number: 8530490Abstract: Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug. A uracil compound represented by the general formula (I) or a salt thereof: wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents —SO2NR1R2 or —NR3SO2—R4, wherein R1 and R2 each represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; R3 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R4 represents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like.Type: GrantFiled: June 2, 2009Date of Patent: September 10, 2013Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Masayoshi Fukuoka, Tatsushi Yokogawa, Seiji Miyahara, Hitoshi Miyakoshi, Wakako Yano, Junko Taguchi, Yayoi Takao
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Publication number: 20120225838Abstract: There is provided an agent for potentiating the effects of an anti-tumor agent. An anti-tumor effect potentiator containing, as an active ingredient, a uracil compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein X represents a C1-5 alkylene group and one of methylene groups constituting the alkylene group is optionally substituted with an oxygen atom; R1 represents a hydrogen atom or a C1-6 alkyl group; R2 represents a hydrogen atom or a halogen atom; and R3 represents a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a (C3-6 cycloalkyl) C1-6 alkyl group, a halogeno-C1-6 alkyl group or a saturated heterocyclic group.Type: ApplicationFiled: November 29, 2010Publication date: September 6, 2012Applicant: Taiho Pharmaceutical Co., Ltd.Inventors: Masayoshi Fukuoka, Tatsushi Yokogawa, Seiji Miyahara, Hitoshi Miyakoshi, Wakako Yano, Junko Taguchi, Yayoi Takao
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Publication number: 20110082163Abstract: Provided is a uracil compound or a salt thereof, which has potent human dUTPase inhibitory activity and is useful as, for example, an antitumor drug. A uracil compound represented by the general formula (I) or a salt thereof: wherein n represents an integer of 1 to 3; X represents a bond, an oxygen atom, a sulfur atom, or the like; Y represents a linear or branched alkylene group having 1 to 8 carbon atoms, or the like; and Z represents —SO2NR1R2 or —NR3SO2—R4, wherein R1 and R2 each represent an alkyl group having 1 to 6 carbon atoms, an aralkyl group which is optionally substituted, or the like; R3 represents an alkyl group having 1 to 6 carbon atoms, or the like; and R4 represents an aromatic hydrocarbon group, an unsaturated heterocyclic group, or the like.Type: ApplicationFiled: June 2, 2009Publication date: April 7, 2011Applicant: Taiho Pharmaceutical Co., Ltd.Inventors: Masayoshi Fukuoka, Tatsushi Yokogawa, Seiji Miyahara, Hitoshi Miyakoshi, Wakako Yano, Junko Taguchi, Yayoi Takao
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Patent number: 5468141Abstract: A mold for injection molding of a thermoplastic resin. The mold comprises a cavity block, a core block, and a cavity formed between the cavity block and the core block and adapted to be filled with a molten resin. The cavity block includes an insulating layer on a cavity side thereof, the insulating layer being made of a material selected from the group consisting of ceramic materials, porcelain enamel, glass materials, heat resistant plastic materials and their composites. The core block includes a release insulating layer on a cavity side thereof, the release insulating layer being made of a material selected from the group consisting of fluorocarbon resins, fluorocarbon resin composite materials, silicone resin composite materials and metal platings with fluorocarbon resin dispersion, the release insulating layer further being adapted to effect both mold releasing and heat insulation.Type: GrantFiled: January 18, 1994Date of Patent: November 21, 1995Assignee: Taiyo Manufacturing Works Co., Ltd.Inventors: Hiroyuki Iwami, Masayoshi Fukuoka, Hiroyuki Kanayama
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Patent number: 5223218Abstract: An instrument for quantitative analysis includes two shutters, one of which prevents light from being introduced into a black box housing a cell holder from the outside through a port in which a cell may be placed in and taken out the black box, and the other of which prevents light from impinging on a photomultiplier tube which is in communication with the black box. The shutters are controlled by a control unit so that one of the shutters opens when the other closes. The instrument also includes detectors which detect whether or not the cell holder and the cell are disposed at predetermined positions, respectively. The detectors output signals to the control unit. The control unit controls an automatic pipetting device to restrict a sample from being introduced into the cell when both the cell holder and the cell are not disposed at the predetermined position.Type: GrantFiled: April 8, 1988Date of Patent: June 29, 1993Assignee: Kabushiki Kaisha MeidenshaInventors: Masayoshi Fukuoka, Akira Matsuyuki