Patents by Inventor Masayoshi Harigai

Masayoshi Harigai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel gene associated with rheumatoid arthritis
    Publication number: 20060172296
    Abstract: It is disclosed that novel polypeptides which has enhanced expression levels in the synovial tissues of human chronic rheumatoid arthritis (RA) patients compared with the synovial tissues of human osteoarthritis (OA) patients, polynucleotides encoding the polypeptides, vectors comprising the polynucleotides, transformant cells comprising the vectors and an antibody against the polypeptide. It is also disclosed that polynucleotides specifically hybridizing with the polynucleotides and having at least 15 nucleotides, a detection method which is useful for RA diagnosis, and a detection kit which is useful for RA diagnosis.
    Type: Application
    Filed: July 18, 2003
    Publication date: August 3, 2006
    Inventors: Masahiro Takeuchi, Noboru Yamaji, Jun Takasaki, Masahiko Akamatsu, Kazuhisa Tsunoyama, Masayoshi Harigai
  • Screening assays for identifying agents that regulate the expression of genes involved in cell death
    Patent number: 5908750
    Abstract: The present invention provides regulatory elements that are linked to genes involved in cell death. For example, the present invention provides a p53-RE.sup.D, which is involved in p53-mediated down-regulation of the bcl-2 gene, and the bax promotor, which contains a p53-RE.sup.U that is involved in p53-mediated up-regulation of the bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death. In addition, the invention provides methods for modulating the level of apoptosis in a cell.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: June 1, 1999
    Assignee: Le Jolla Cancer Research Foundation
    Inventors: John C. Reed, Toshiyuki Miyashita, Masayoshi Harigai, Motoi Hanada
  • Promotors that regulate the expression of genes involved in cell death
    Patent number: 5659024
    Abstract: The present invention provides regulatory elements that are linked to genes involved in cell death. For example, the present invention provides a p53-RE.sup.D, which is involved in p53-mediated down-regulation of the bcl-2 gene, and the bax promotor, which contains a p53-RE.sup.U that is involved in p53-mediated up-regulation of the bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death. In addition, the invention provides methods for modulating the level of apoptosis in a cell.
    Type: Grant
    Filed: October 27, 1994
    Date of Patent: August 19, 1997
    Assignee: The Burnham Institute
    Inventors: John C. Reed, Toshiyuki Miyashita, Masayoshi Harigai, Motoi Hanada
  • BCL-2 gene inhibitory element binding factor
    Patent number: 5643727
    Abstract: The present invention provides a bcl-2 gene inhibitory element (BIE), which can inhibit expression of a gene in position-dependent and orientation-dependent manner. The invention provides, for example, BIE-1, having the nucleotide sequence 5'-CAAGAATGCAA-3' (SEQ ID NO: 1), which acts in an orientation-dependent and position-dependent manner to down-regulate the expression of the bcl-2 gene. The invention also provides a BIE binding factor (BBF), which is a cellular factor that can bind to a BIE. The invention provides, for example, BBF-A, which binds to BIE-1, including a nucleic acid sequence (SEQ ID NO: 8) encoding a portion of the amino acid sequence (SEQ ID NO: 9) of BBF-A. The invention further provides an antibody that specifically binds BBF-A. The invention also provides screening assays for identifying agents that can increase or decrease the binding of a BBF to a BIE, modulate the expression of a nucleic acid molecule linked to a BIE or modulate apoptosis in a cell.
    Type: Grant
    Filed: February 16, 1995
    Date of Patent: July 1, 1997
    Assignee: La Jolla Cancer Research Foundation
    Inventors: John C. Reed, Masayoshi Harigai
  • Method of down-regulating a gene linked to a P-53 responsive element
    Patent number: 5484710
    Abstract: The present invention provides regulatory elements that are linked to genes involved in cell death and are regulated by p53 tumor suppressor protein. Examples of such p53 responsive elements (p53-RE) include p53-RE.sup.D, which is involved in p53-mediated down-regulation of the Bcl-2 gene, and p53-RE.sup.U, which is involved in p53-mediated up-regulation of the Bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death and contains a p53-RE.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: January 16, 1996
    Assignee: La Jolla Cancer Research Foundation
    Inventors: John C. Reed, Toshiyuki Miyashita, Masayoshi Harigai, Motoi Hanada