Abstract: A loosening detection structure used to detect loosening of a bolt includes a material that is disposed between a fixing subject steel plate and a head portion of a metal bolt for fixing the steel plate and either attached to a seating surface of the head portion of the bolt or attached to a washer disposed between the steel plate and the head portion of the bolt, and that has electrical characteristics that vary in response to variation in a force for fastening the bolt to the steel plate.

Abstract: A transducer includes a conductive sheet installed on a sheath of a cable, an insulative sheet installed on the conductive sheet, holes being formed in predetermined positions of the insulative sheet, and a conductive sheet installed on the insulative sheet, holes being formed in predetermined positions of the conductive sheet. The transducer has structure in which, when the cable is tightened by the screw from the top of the conductive sheet and fixed, the distal end of the screw comes into contact with the conductive sheet passing through the holes formed in the insulative sheet and the conductive sheet, and the conductive sheet and the conductive sheet are electrically connected.

Abstract: A three-dimensional shaping device includes a plasticizing unit configured to plasticize a material to generate a plasticized material, a nozzle configured to discharge the plasticized material, a stage including a shaping surface on which the plasticized material is stacked, a moving unit configured to change relative positions of the nozzle and the stage, a plate-shaped first heating unit including a heater configured to heat the plasticized material on the stage, a through-hole being formed in the first heating unit, and a first supporting unit configured such that a relative position thereof to the stage changes together with the nozzle, the first supporting unit supporting the first heating unit to thereby dispose the first heating unit in a position opposed to the stage. At a shaping time, at least a part of the nozzle is located in the through-hole. The first supporting unit includes a posture changing unit configured to allow a change in a posture of the first heating unit.

Abstract: An amorphous alloy soft magnetic powder contains a particle having a composition with a compositional formula (Fe1-xCrx) a (Si1-yBy)100-a-bCb expressed by an atomic ratio, in which 0<x?0.06, 0.3?y?0.7, 70.0?a?81.0, and 0<b?3.0, and when XAFS measurement is performed with an analysis depth set to a bulk, an obtained Fe—K absorption edge XANES spectrum has a first absorption edge structure having a peak A present in a range of 7113±1 eV and a first continuous band structure positioned at a higher energy side than the first absorption edge structure, and an intensity of the peak A at 7113 eV is 0.60 or more and 0.90 or less when an intensity of the first continuous band structure is 1.

Abstract: A charged depth filter for removing cells and/or cellular debris from a biopharma feedstock having a first functionalized nonwoven layer having a first calculated pore size and a first dynamic charge capacity; a second functionalized nonwoven layer having a second calculated pore size and a second dynamic charge capacity positioned after the first functionalized nonwoven layer in the direction of the biopharma feedstock flow, and wherein the first calculated pore size is greater than the second calculated pore size, and the first dynamic charge capacity is less than the second dynamic charge capacity.

Abstract: A non-transitory computer-readable storage medium storing therein an information management program for causing a computer to execute a process comprises: receiving property information indicating a reliability of a post uploaded on the Internet and a digital signature generated from the property information; and storing the property information, to which identification information of the post and the digital signature are added, in a storage.

Abstract: The present invention relates to a compound having inhibitory activity against KRAS G12D mutation or a salt thereof, and relates to a pharmaceutical composition comprising the compound as an active ingredient.

Abstract: A method of applying a two-part dental sealant is described comprising providing a syringe device (1) comprising a cartridge (10) including first and second chamber. The first chamber contains a first part of a dental sealant comprising a (meth)acrylate resin and an oxidizing curing agent. The second chamber contains a second part of a dental sealant comprising a (meth)acrylate resin and a reducing curing agent that reacts with the oxidizing curing agent of the first chamber. The first and/or second part of the dental sealant further comprise a single component or multiple components that neutralize acid and promote remineralization. The syringe device comprises a dispensing nozzle (17) comprising a static mixer and an outlet at one end of the cartridge and a plunger (20) at the opposing end of the cartridge. Also described is a kit for storing and applying the dental sealant is described.

Abstract: A sensor element and sensor comprising the sensing element. The sensor includes, in order, an absorptive layer, a metallic layer and an optically transparent, dielectric substrate. The absorptive layer has a polymer of intrinsic microporosity having an average pore volume of at least 0.1 nm3. The metallic layer has a plurality of openings each extending from the first to the second major surface of the metallic layer, the openings having a pitch in a range from 50 nm to 5000 nm, wherein the openings have an opening size in a range from 5% to 95% percent of the pitch.

Abstract: A composition and a method for culturing cells. The composition includes a plurality of buoyant hollow particles, the buoyant hollow particles comprising a siliceous surface; and a plurality of mammalian cells attached to the siliceous surface of the buoyant hollow particles; wherein the buoyant hollow particles are less dense than a media; and wherein the average seeding density is 3-50 adherent cells/buoyant hollow particle.

Abstract: A composition and method of detecting an analyte in a sample using the composition, the composition including: a liquid that includes water; a plurality of first hollow glass bubbles in the liquid; a plurality of covalently attached first affinity groups that are covalently attached to at least some of the plurality of first hollow glass bubbles; and a plurality of first detector compound molecules not covalently bonded to the plurality of first hollow glass bubbles; wherein the first detector compound molecules include a first detectable group that is detected at a first wavelength; and wherein the first hollow glass bubbles have: a density of less than 0.60 gram/mole; a span of less than 1.0; and a plurality of covalently attached first affinity groups.

Abstract: A fluid pressure control device includes a neutral passage, a control valve provided in the neutral passage, a first supply passage, and a discharge passage, the control valve has, a switching valve configured to control a flow of a working fluid to the discharge passage from the first actuator in accordance with a pressure in a pilot chamber to which a part of the working fluid supplied from the first supply passage to the first actuator is led, and a throttle portion configured to throttle the flow of the working fluid supplied to the first actuator from the first supply passage, and the pressure on an upstream side of the throttle portion is led to the pilot chamber.

Abstract: A control valve includes a housing formed with first and second supply ports, first and second actuator ports, and a pilot port, and a spool accommodated slidably in the housing, and the spool is configured to allow the first supply port and the pilot port to communicate with each other both at the first communication position and the second communication position.

Abstract: Provided are a novel pyrimidine compound that inhibits HER2 activity and exhibits brain penetration properties, or a salt thereof, and a pharmaceutical composition comprising the same. A compound represented by the following formula (I), or a salt thereof: wherein R1 represents a C1-C4 alkyl group optionally having a C1-C4 alkoxy group as a substituent, or a C3-C4 cycloalkyl group; R2 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group optionally having 1 to 5 C1-C4 alkoxy groups or fluorine atoms each as a substituent(s), or a C1-C6 alkoxy group; R3 represents a hydrogen atom, or a C1-C4 alkyl group optionally having 1 to 5 fluorine atoms as a substituent(s); R4 represents a hydrogen atom or a C1-C4 alkyl group; and R5 represents a phenyl group optionally having 1 to 3 substituents selected from fluorine atoms and chlorine atoms.

Abstract: A hardenable (e.g. dental) compositions is described comprising an encapsulated material. The encapsulated material comprises a basic core material and an inorganic shell material having certain viscosity criteria. Also described are dispensing devices and kits are described comprising a hardenable (e.g. dental) composition comprising a liquid material and an encapsulated material wherein the encapsulated material comprises a basic core material and an inorganic shell material comprising a metal oxide surrounding the core. The dispensing devices and kits can facilitate the methods of applying the hardenable composition. The hardenable or hardened (e.g. cured) composition can provide various technical effects such as a delayed release of a basic core material, a delayed increase in basicity, promoting remineralization of a tooth or bone structure, and increasing the average alkaline phosphatase (ALP) activity of pulp cells. In some embodiments, the composition is a dental (e.g.

Abstract: A fluid pressure control device includes a switching valve, a main pilot passage and a sub pilot passage, the switching valve is configured to be switched to the open position when the working fluid is supplied to the pilot chamber, and to be switched to the throttled position with opening on the downstream side of the switching valve in the neutral passage, and the sub pilot passage is provided with a throttle portion and a check valve in parallel in the throttle portion.

Abstract: Provided is a water-purifying agent that is excellent in water purifying performance, can be suitably used in an automated wastewater purification apparatus, and is formed of a granulated product including a mixture of a powder of Corchorus olitorius and a polymeric flocculant, wherein a median diameter of the granulated product is 250 micrometers or greater but 850 micrometers or less.

Abstract: Provided are a novel pyrimidine compound that inhibits HER2 activity and exhibits brain penetration properties, or a salt thereof, and a pharmaceutical composition comprising the same. A compound represented by the following formula (I), or a salt thereof: wherein R1 represents a C1-C4 alkyl group optionally having a C1-C4 alkoxy group as a substituent, or a C3-C4 cycloalkyl group; R2 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group optionally having 1 to 5 C1-C4 alkoxy groups or fluorine atoms each as a substituent(s), or a C1-C6 alkoxy group; R3 represents a hydrogen atom, or a C1-C4 alkyl group optionally having 1 to 5 fluorine atoms as a substituent(s); R4 represents a hydrogen atom or a C1-C4 alkyl group; and R5 represents a phenyl group optionally having 1 to 3 substituents selected from fluorine atoms and chlorine atoms.

Abstract: There is provided a water jacket spacer set in a groove-like coolant passage of a cylinder block of an internal combustion engine including cylinder bores and set in an entire circumferential direction or a part in a circumferential direction of the groove-like coolant passage when viewed in the circumferential direction, wherein a coolant passage opening through which coolant flowing on the rear surface side of the water jacket spacer passes to flow to an inner side of the water jacket spacer is formed on at least one place of upper portions of inter-bore portions, a guide wall for guiding the coolant is formed in a vicinity of the coolant passage opening, such that the coolant flows into the coolant passage opening; and an inclined wall is formed on the rear surface side of bore portions of a position where the coolant is supplied into the groove-like coolant passage, the inclined wall extending with an upward inclination to create a flow of the coolant toward the coolant passage opening.

Abstract: A composition for use in bioseparation. The composition includes a plurality of hollow particles having a siliceous surface. The composition further includes a surface-modifying agent bonded to the hollow particles. The surface-modifying agent includes a binding segment and a reactive segment. The binding segment includes a silyl group and the reactive segment includes a reactive nitrogen group.