Abstract: When being connected to a macro cell (S-MeNB) and a small cell (SeNB), a user equipment device performs a pre-handover process of disconnecting the connection with the SeNB before a handover process of switching a macro cell connected with the UE from the macro cell (S-MeNB) that is a moving source to a macro cell (T-MeNB) that is a moving destination along with moving of the UE, and after the handover process, performs a post-handover process of reestablishing the connection with the SeNB.

Abstract: An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries.

Abstract: One aspect of the present invention is an information processing system that includes a computing machine installed in a computing machine base, and a first transmitting/receiving apparatus connected to the computing machine, a second transmitting/receiving apparatus installed in a user base that is used by a user, and a device connected to the second transmitting/receiving apparatus, and a control apparatus configured to control connection between the first transmitting/receiving apparatus and the second transmitting/receiving apparatus. In the information processing system, the control apparatus is configured to change the connection between the first transmitting/receiving apparatus and the second transmitting/receiving apparatus, and copy the state of the pre-change computing machine from the pre-change computing machine into the post-change computing machine.

Abstract: An organ preservation container includes a container body, joints, and tubes. The container body includes a bottom plate and a side wall. The side wall has through holes. Each joint has a through hole. The tubes are connected to the joints from the inner side of the container body. Thus, the tubes are arranged in advance in the container body in an organ transplant operation. This enables a small number of people to speedily conduct the work of placing an organ removed from the donor in the container body and connecting the tubes to blood vessels in the organ.

Abstract: One aspect of the present invention is an information processing system that includes a computing machine installed in a computing machine base, and a first transmitting/receiving apparatus connected to the computing machine, a second transmitting/receiving apparatus installed in a user base that is used by a user, and a device connected to the second transmitting/receiving apparatus, and a control apparatus configured to control connection between the first transmitting/receiving apparatus and the second transmitting/receiving apparatus. In the information processing system, the control apparatus is configured to change the connection between the first transmitting/receiving apparatus and the second transmitting/receiving apparatus, and copy the state of the pre-change computing machine from the pre-change computing machine into the post-change computing machine.

Abstract: An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries.

Abstract: An organ container has a pouch-shaped body having contraction and expansion properties and an opening. In a no-load condition, a maximum width of the opening is less than a maximum width of the body. On the other hand, the opening is expandable to a state in which the maximum width of the opening becomes greater than the maximum width of the body. Thus, the organ container covers the surface of an organ along the surface of the organ. Accordingly, when an organ is placed in the body cavity of a recipient, the organ container does not expand around the organ. For this reason, the organ container is less likely to hinder work during operation. Moreover, the organ container covers most part of the organ and thereby suppresses a temperature rise in the organ.

Abstract: A perfusion device includes first inlet piping that connects a reservoir and a portal vein, second inlet piping that connects the reservoir and a hepatic artery, a first pump that produces a flow in the first inlet piping, and a second pump that produces a flow in the second inlet piping. The first and second pumps are of the same type, each having a rotating portion for solution sending. The rotating portion of the first pump has a greater diameter than the rotating portion of the second pump. Thus, even if the first and second pumps make the same number of rotations, the ratio of the flow rate of the perfusate between the first inlet piping and the second inlet piping can be made almost constant. Accordingly, the perfusate is supplied under appropriate conditions to the portal vein and the hepatic artery with a simple configuration.

Abstract: A perfusion method includes a) cleaning a blood vessel of an organ by causing a first perfusate to flow into the blood vessel and letting the first perfusate out of the organ through the blood vessel, and b) after the operation a), preserving the organ while causing a second perfusate to flow into the blood vessel and letting the second perfusate out of the organ through the blood vessel. The first perfusate and the second perfusate each contain a biocompatible solution and a serine protease and have an osmotic pressure ratio higher than or equal to 1 and lower than or equal to 5 relative to the saline solution. The concentration of the serine protease in the second perfusate is lower than that in the first perfusate. Accordingly, it is possible to dissolve thrombi in the blood vessel or prevent the formation of new thrombi during organ perfusion treatment.

Abstract: An organ container has a pouch-shaped body having contraction and expansion properties and an opening. In a no-load condition, a maximum width of the opening is less than a maximum width of the body. On the other hand, the opening is expandable to a state in which the maximum width of the opening becomes greater than the maximum width of the body. Thus, the organ container covers the surface of an organ along the surface of the organ. Accordingly, when an organ is placed in the body cavity of a recipient, the organ container does not expand around the organ. For this reason, the organ container is less likely to hinder work during operation. Moreover, the organ container covers most part of the organ and thereby suppresses a temperature rise in the organ.

Abstract: The invention provides pyrazolo[1,5-a]pyrimidine derivatives which are useful as potent analgesics and represented by the formula ##STR1## wherein R.sup.1 is lower alkenyl, hydroxy(lower)alkyl, (lower)alkylthio(lower)alkyl, (lower)alkanoyloxy(lower)alkyl, (lower)alkoxy(lower)alkyl, furyl or thienyl, R.sup.2 is pyridyl, 1-oxide-pyridyl, lower alkyl-substituted pyrazinyl, lower alkyl-substituted pyrimidinyl, or phenyl which may have 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy and halogen, R.sup.3 is hydrogen or halogen, and A is a single bond or lower alkylene.

Abstract: The invention provides an analgesic composition containing as an active ingredient a specific pyrimidine derivative represented by one of the follwing formulas (1) to (3): ##STR1## wherein the substituents are as defined herein. This composition exhibits potent analgesic activity and is effective for alleviating various types of pain such as postoperative pain.

Abstract: The invention provides a pyrazolo?1,5-a!pyrimidine derivative of the following formula (1): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, R.sup.6, Q, A and n are defined in the description; and R.sup.2 is naphthyl, cycloalkyl, furyl, thienyl, optionally halogen-substituted pyridyl, optionally halogen-substituted phenoxy, or phenyl which may have 1 to 3 substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro, halogen-substituted lower alkyl, halogen-substituted lower alkoxy, lower alkoxycarbonyl, hydroxyl, phenyl(lower)alkoxy, amino, cyano, lower alkanoyloxy, phenyl and di(lower)alkoxyphos-phoryl(lower)alkyl. This derivative is useful as a potent analgesic.