Patents by Inventor Mason Duncan

Mason Duncan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis of N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids
    Patent number: 7294740
    Abstract: The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: November 13, 2007
    Assignee: Wyeth
    Inventors: Scott Mason Duncan, Augustine Tobi Osuma, Sylvain Daigneault, Michel Bernatchez
  • Process for the synthesis of N-nacyl-2-amino-4-alkoxy-5-nitrobenzoic acids
    Patent number: 7227037
    Abstract: The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: June 5, 2007
    Assignee: Wyeth
    Inventors: Scott Mason Duncan, Augustine Tobi Osuma, Sylvain Daigneault, Michel Bernatchez
  • Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
    Patent number: 7126025
    Abstract: This invention provides a compound of Formula (I): wherein S1 and S2 are each independently, hydrogen, alkyl, alkenyl, alkynyl, aralkyl, substituted or unsubstituted aryl, and S1 and S2 together with the nitrogen to which they are attached form a nitrogen containing heteroaryl and a pharmaceutically acceptable salt thereof; a method of preparing the compound of Formula (I), and use of the compound of Formula (I) in the preparation of 3-cyano quinolines.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: October 24, 2006
    Assignee: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Mason Duncan, Jianxin Ren
  • Process for the synthesis of 3-cyano-6-alkoxy-7-nitro-4-quinolones
    Patent number: 6933388
    Abstract: There is provided a process for the preparation of 3-cyano-6-alkoxy-7-nitro-4-quinolone intermediates useful for the preparation of protein tyrosine kinase (PTK) inhibitors which are useful in the treatment of cancer of the formula: wherein R is alkyl(C1-C3) prepared by reacting a substituted anthranilate with N,N-dimethylformamide dimethyacetal to obtain a N,N-dimethylamidine which is condensed with t-butylcyanoacetate to obtain a N-(2-cyano-2-t-butoxycarbonylvinyl)anthranilate, which is hydrolyzed to yield a N-(2-cyano-2-carboxyvinyl)anthranilate followed by decarboxylating to obtain a N-(2-cyano-2-carboxyvinyl)anthranilate followed by cyclizing to obtain a 3-cyano-6-alkoxy-7-nitro-4-quinolone.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: August 23, 2005
    Assignee: Wyeth Holdings Corporation
    Inventors: Scott Mason Duncan, Miguel Angel Pagan, Middleton Brawner Floyd, Jr.
  • Process for the synthesis of 3-cyano-6-alkoxy-7-nitro-4-quinolones
    Publication number: 20040204587
    Abstract: There is provided a process for the preparation of 3-cyano-6-alkoxy-7-nitro-4-quinolone intermediates useful for the preparation of protein tyrosine kinase (PTK) inhibitors which are useful in the treatment of cancer of the formula: 1
    Type: Application
    Filed: April 7, 2004
    Publication date: October 14, 2004
    Applicant: Wyeth Holdings Corporation
    Inventors: Scott Mason Duncan, Miguel Angel Pagan, Middleton Brawner Floyd
  • Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
    Publication number: 20040162442
    Abstract: This invention provides a compound of Formula (I): 1
    Type: Application
    Filed: January 15, 2004
    Publication date: August 19, 2004
    Applicant: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Mason Duncan, Jianxin Ren