Patents by Inventor Massimiliano Tomasulo
Massimiliano Tomasulo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240125773Abstract: The disclosure relates to compositions comprising a non-fluorescent component of a polymer dye such as a monomeric component of a polymer dye, a photo-bleached polymer dye, and/or a polymer dye comprising a quenching moiety, for reducing non-specific interactions of polymer dye conjugates, for example, in Flow Cytometric Analysis of a biological sample. Methods for using such compositions, and kits comprising such compositions are also provided.Type: ApplicationFiled: February 4, 2022Publication date: April 18, 2024Inventors: Frederic MONSONIS, Boi Hoa SAN, Arunkumar EASWARAN, Massimiliano TOMASULO, Sergei GULNIK, Rajesh VENKATESH, Shiva Ranjini SRINIVASAN
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Publication number: 20230399565Abstract: The present disclosure provides fused dihydrophenanthrene (DHP) monomers and fluorescent fused DHP polymers, water-soluble fluorescent polymers and copolymers, water-soluble fluorescent polymer complexes, and their use in methods for detecting an analyte in a sample.Type: ApplicationFiled: June 9, 2023Publication date: December 14, 2023Inventors: Massimiliano Tomasulo, Mukesh Mudgal, Arunkumar Easwaran, Sergei Gulnik
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Publication number: 20230192943Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.Type: ApplicationFiled: January 6, 2023Publication date: June 22, 2023Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
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Patent number: 11584825Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.Type: GrantFiled: December 11, 2019Date of Patent: February 21, 2023Assignee: Beckman Coulter, Inc.Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
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Patent number: 11453654Abstract: The present invention relates to photochromic indeno fused phenanthrenopyran compounds represented by the following Formula (I). With some embodiments, the photochromic compounds represented by Formula (I) include at least one lengthening group (e.g., R6 and/or R7 each independently being a lengthening group) and the compounds of the present invention are photochromicdichroic compounds. The present invention also relates to photochromic compositions and photochromic articles, such as photochromic ophthalmic articles that include one or more photochromic compounds represented by Formula (I).Type: GrantFiled: May 10, 2017Date of Patent: September 27, 2022Assignee: Transitions Optical, Ltd.Inventors: Anil Kumar, Darrin R. Dabideen, Shengwen Yuan, Massimiliano Tomasulo
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Publication number: 20200190253Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.Type: ApplicationFiled: December 11, 2019Publication date: June 18, 2020Inventors: Arunkumar Easwaran, Sergei Gulnik, Massimiliano Tomasulo
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Publication number: 20200048216Abstract: The present invention relates to photochromic indeno fused phenanthrenopyran compounds represented by the following Formula (I). With some embodiments, the photochromic compounds represented by Formula (I) include at least one lengthening group (e.g., R6 and/or R7 each independently being a lengthening group) and the compounds of the present invention are photochromicdichroic compounds. The present invention also relates to photochromic compositions and photochromic articles, such as photochromic ophthalmic articles that include one or more photochromic compounds represented by Formula (I).Type: ApplicationFiled: May 10, 2017Publication date: February 13, 2020Inventors: Anil Kumar, Darrin R. Dabideen, Shengwen Yuan, Massimiliano Tomasulo
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Patent number: 10501477Abstract: The present invention relates to photochromic compounds, such as thienochromene compounds represented by the following Formulas (1a) and/or (1b). The present invention also relates to photochromic compositions and articles containing one or more such photochromic thienochromene compounds.Type: GrantFiled: March 10, 2015Date of Patent: December 10, 2019Assignee: Transitions Optical, Inc.Inventors: Jun Deng, Brian R. Stepp, Eric Spitler, Wenjing Xiao, Massimiliano Tomasulo, Robert W. Walters
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Patent number: 10423061Abstract: A multilayer photochromic article can include a photochromic substrate, which may include a first photochromic layer defining a surface of the substrate, and a second photochromic layer positioned between the surface of the photochromic substrate and a source of actinic radiation, and in which the photochromic substrate and the second photochromic layer are selected such that the fade half-life of the photochromic substrate or the half-life of the first photochromic layer defining the surface of the substrate are greater than the fade half-life of the second photochromic layer.Type: GrantFiled: September 3, 2015Date of Patent: September 24, 2019Assignee: Transitions Optical, Inc.Inventors: Massimiliano Tomasulo, Cory Brown, Elizabeth Ann Zezinka
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Publication number: 20180210330Abstract: A multilayer photochromic article can include a photochromic substrate, which may include a first photochromic layer defining a surface of the substrate, and a second photochromic layer positioned between the surface of the photochromic substrate and a source of actinic radiation, and in which the photochromic substrate and the second photochromic layer are selected such that the fade half-life of the photochromic substrate or the half-life of the first photochromic layer defining the surface of the substrate are greater than the fade half-life of the second photochromic layer.Type: ApplicationFiled: September 3, 2015Publication date: July 26, 2018Inventors: Massimiliano Tomasulo, Cory Brown, Elizabeth Ann Zezinka
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Patent number: 9630902Abstract: The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride.Type: GrantFiled: November 10, 2015Date of Patent: April 25, 2017Assignee: Transitions Optical, Inc.Inventors: Meng He, Massimiliano Tomasulo, Allison Greene, Anil Kumar
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Publication number: 20160060205Abstract: The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride.Type: ApplicationFiled: November 10, 2015Publication date: March 3, 2016Inventors: Meng He, Massimiliano Tomasulo, Allison Greene, Anil Kumar
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Patent number: 9206151Abstract: The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride.Type: GrantFiled: November 20, 2013Date of Patent: December 8, 2015Assignee: Transitions Optical, Inc.Inventors: Meng He, Massimiliano Tomasulo, Allison Greene, Anil Kumar
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Patent number: 9051332Abstract: The present invention relates to photochromic indeno-fused ring pyran compounds represented by the following Formula (I-A): The present invention also relates to photochromic dichroic compounds, such as represented by Formula (I-A), in which (i) Z2 is a group N—R13 in which R13 is a group L, and (ii) optionally at least one R1 independently for each n is selected from a group L, in which the group L independently in each case is a lengthening group that provides the photochromic compound with dichroic properties, in accordance with some embodiments. The present invention also relates to photochromic articles, such as photochromic ophthalmic articles, that include one or more photochromic compounds according to the present invention, such as represented by Formula (I-A).Type: GrantFiled: November 20, 2013Date of Patent: June 9, 2015Assignee: Transitions Optical, Inc.Inventors: Meng He, Massimiliano Tomasulo, Anil Kumar
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Publication number: 20150141662Abstract: The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride.Type: ApplicationFiled: November 20, 2013Publication date: May 21, 2015Applicant: Transitions Optical, Inc.Inventors: Meng He, Massimiliano Tomasulo, Allison Greene, Anil Kumar
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Publication number: 20150141661Abstract: The present invention relates to photochromic indeno-fused ring pyran compounds represented by the following Formula (I-A): The present invention also relates to photochromic dichroic compounds, such as represented by Formula (I-A), in which (i) Z2 is a group N—R13 in which R13 is a group L, and (ii) optionally at least one R1 independently for each n is selected from a group L, in which the group L independently in each case is a lengthening group that provides the photochromic compound with dichroic properties, in accordance with some embodiments. The present invention also relates to photochromic articles, such as photochromic ophthalmic articles, that include one or more photochromic compounds according to the present invention, such as represented by Formula (I-A).Type: ApplicationFiled: November 20, 2013Publication date: May 21, 2015Applicant: Transitions Optical, Inc.Inventors: Meng He, Massimiliano Tomasulo, Anil Kumar
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Publication number: 20150141663Abstract: The present invention relates to intermediate compounds represented by the following Formula (I-A), The intermediate compounds of the present invention, such as represented by Formula (I-A), can be used to prepare photochromic compounds, such as photochromic fused ring indenopyran compounds, including but not limited to photochromic fused ring indeno-naphtho-pyran compounds.Type: ApplicationFiled: November 20, 2013Publication date: May 21, 2015Applicant: Transitions Optical, Inc.Inventors: Meng He, Massimiliano Tomasulo, Anil Kumar
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Patent number: 9029565Abstract: The present invention relates to intermediate compounds represented by the following Formula (I-A), The intermediate compounds of the present invention, such as represented by Formula (I-A), can be used to prepare photochromic compounds, such as photochromic fused ring indenopyran compounds, including but not limited to photochromic fused ring indeno-naphtho-pyran compounds.Type: GrantFiled: November 20, 2013Date of Patent: May 12, 2015Assignee: Transitions Optical, Inc.Inventors: Meng He, Massimiliano Tomasulo, Anil Kumar
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Patent number: 9028728Abstract: The present invention relates to photochromic materials that include one or more indeno-fused naphthopyrans that have particular groups at the 7, 11, and 13 positions thereof, and at the position alpha to the oxygen of the pyran ring thereof. With some embodiments, hydrogen or an alkoxy group is bonded to the 7 position, an optionally substituted phenyl is bonded to the 11 position, two alkyl groups are bonded to the 13 position, and two optionally substituted phenyl groups are bonded to the position alpha to the oxygen of the pyran ring of the indeno-fused naphthopyran compound. The 13 position of the indeno-fused naphthopyrans is free of ether groups in which an ether oxygen is bonded to the 13 position, and hydroxyl. The present invention also relates to photochromic articles and compositions that include such indeno-fused naphthopyrans.Type: GrantFiled: December 8, 2011Date of Patent: May 12, 2015Assignee: Transitions Optical, Inc.Inventors: Kevin E. Bancroft, Anu Chopra, Xiao-Man Dai, Beon-Kyu Kim, David B. Knowles, Jason R. Lewis, Victor A. Montes, Stephen D. Straight, Massimiliano Tomasulo, Barry Van Gemert, Robert W. Walters, Wenjing Xiao, Huayun Yu, Elizabeth A. Zezinka
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Patent number: 8920928Abstract: Described herein are compounds generally comprising an indeno[2?,3?:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles.Type: GrantFiled: December 14, 2011Date of Patent: December 30, 2014Assignee: Transitions Optical, Inc.Inventors: Meng He, Darrin R. Dabideen, Sujit Mondal, Xiao-Man Dai, Ruisong Xu, Wenjing Xiao, Massimiliano Tomasulo, Huayun Yu, Anu Chopra, Anil Kumar