Patents by Inventor Massimo Castorina

Massimo Castorina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL DUAL TARGETING ANTITUMORAL CONJUGATES
    Publication number: 20110160147
    Abstract: The present invention relates to dual-targeting cytotoxic compounds of formula (I) and to their preparation. The described compounds are endowed with tumour specific action, incorporating three functional units: a tumour recognition moiety and a tumour selective enzymatic substrate sequence connected together by means of a spacer. These conjugates are designed to guarantee serum stability and, at the same time, the desired action inside the tumour cells as a result of enzymatic cleavability. [(L-D)nE]m-F-D-PI-SI-CT Formula (I).
    Type: Application
    Filed: September 2, 2009
    Publication date: June 30, 2011
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Alma Dal Pozzo, Emiliano Esposito, Minghong Ni, Sergio Penco, Claudio Pisano, Massimo Castorina, Loredana Vesci
  • 2-(N-acyl)amino-6,7-dimethoxy tetralines, and pharmaceutical compositions having antihypertensive activity containing same
    Patent number: 5053424
    Abstract: 2-(N-acyl)amino-6,7-dimethoxy tetraline of general formula (I) ##STR1## wherein R is selected from hydrogen and ethyl and A is an aminoacyl or dipeptidyl radical are endowed with potent anti-hypertensive activity.
    Type: Grant
    Filed: July 30, 1990
    Date of Patent: October 1, 1991
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Mauro Marzi, Maria O. Tinti, Licia Pacifici, Carla Franceschelli, Massimo Castorina