Patents by Inventor Mathias Ehrich

Mathias Ehrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and processes for non-invasive assessment of genetic variations
    Patent number: 9367663
    Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: June 14, 2016
    Assignee: SEQUENOM, INC.
    Inventors: Cosmin Deciu, Zeljko Dzakula, Mathias Ehrich, Sung Kyun Kim
  • METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
    Publication number: 20160145685
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: March 13, 2014
    Publication date: May 26, 2016
    Inventors: Taylor Jacob JENSEN, Mathias EHRICH
  • Base specific cleavage of methylation-specific amplification products in combination with mass analysis
    Patent number: 9249456
    Abstract: Methods, combinations and kits are provided for identifying the methylation state of a target nucleic acid molecule, the methylation state of a nucleotide locus in a target nucleic acid molecule, or for identifying the locus of one or more methylated or unmethylated nucleotides in a target nucleic acid molecule. Methylation state identification is performed by treating a methylated target nucleic acid molecule with a reagent that modifies one or more nucleotides in the target nucleic acid molecule as a function of the methylation state of the target nucleic acid molecule, methylation specifically amplifying treated target nucleic acid molecule, fragmenting amplified products, and detecting one or more fragments to thereby identify the methylation state of a target nucleic acid molecule, the methylation state of a nucleotide locus in a target nucleic acid molecule, or the locus of one or more methylated or unmethylated nucleotides in a target nucleic acid molecule.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: February 2, 2016
    Assignee: AGENA BIOSCIENCE, INC.
    Inventors: Mathias Ehrich, Dirk Johannes Van Den Boom
  • PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSES
    Publication number: 20150275304
    Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.
    Type: Application
    Filed: June 10, 2015
    Publication date: October 1, 2015
    Inventors: Mathias Ehrich, Anders Nygren Olof Herman
  • Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
    Patent number: 8962247
    Abstract: Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: February 24, 2015
    Assignee: Sequenom, Inc.
    Inventors: Mathias Ehrich, Anders Olof Herman Nygren, Taylor Jacob Jensen
  • Restriction endonuclease enhanced polymorphic sequence detection
    Patent number: 8722336
    Abstract: Provided in part herein is an improved method for the detection of specific polymorphic alleles in a mixed DNA population. The method comprises enriching the relative percentage of a given polymorphic allele that is exponentially amplifiable by PCR. Provided also are methods for selectively enriching target nucleic acid, for example, fetal nucleic acid in a maternal sample. In the case of detecting fetal nucleic acid in a maternal sample, a restriction enzyme is introduced that can discriminate between the alleles of a polymorphic site. In some embodiments, the maternal allele is digested and nucleic acid comprising the paternal allele is relatively enriched.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: May 13, 2014
    Assignee: Sequenom, Inc.
    Inventors: Mathias Ehrich, Dirk Johannes Van Den Boom
  • Method for accurate assessment of DNA quality after bisulfite treatment
    Patent number: 8673571
    Abstract: The present invention is directed to methods useful for determining DNA quality after bisulfite treatment. The methods include a PCR-based assay, which allows ab-initio assessment of the DNA quality after bisulfite treatment and can help to prevent inaccurate quantitative measurement resulting from poor bisulfite treatment.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: March 18, 2014
    Assignee: Sequenom, Inc.
    Inventor: Mathias Ehrich
  • Restriction endonuclease enhanced polymorphic sequence detection
    Patent number: 8652780
    Abstract: Provided is an improved method for the detection of specific polymorphic alleles in a mixed DNA population. The method comprises enriching the relative percentage of a given polymorphic allele that is exponentially amplifiable by PCR. Also provided are methods for selectively enriching target nucleic acid, for example, fetal nucleic acid in a maternal sample. In the case of detecting fetal nucleic acid in a maternal sample, a restriction enzyme is introduced that can discriminate between the alleles of a polymorphic site. Preferably, the maternal allele is digested and nucleic acid comprising the paternal allele is relatively enriched.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: February 18, 2014
    Assignee: Sequenom, Inc.
    Inventors: Mathias Ehrich, Dirk Johannes Van den Boom
  • METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
    Publication number: 20130325360
    Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: March 12, 2013
    Publication date: December 5, 2013
    Applicant: SEQUENOM, INC.
    Inventors: COSMIN DECIU, Zeljko Dzakula, Mathias Ehrich, Taylor Jacob Jensen
  • Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification
    Patent number: 8551707
    Abstract: The invention in part provides nucleic acid-based assays, which are particularly useful for non-invasive prenatal testing. The invention in part provides compositions and methods for RhD typing, detecting the presence of fetal nucleic in a sample, determining the relative amount of fetal nucleic acid in a sample and determining the sex of a fetus, wherein each of the assays may be performed alone or in combination.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: October 8, 2013
    Assignee: Sequenom, Inc.
    Inventors: Paul Andrew Oeth, Mathias Ehrich
  • METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
    Publication number: 20130230858
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: March 1, 2013
    Publication date: September 5, 2013
    Applicant: Sequenom, Inc.
    Inventors: Charles R. CANTOR, Grace DeSANTIS, Reinhold Mueller, Mathias Ehrich
  • Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
    Patent number: 8476013
    Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: July 2, 2013
    Assignee: Sequenom, Inc.
    Inventors: Mathias Ehrich, Anders Olof Herman Nygren
  • PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSES
    Publication number: 20130150249
    Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
    Type: Application
    Filed: June 13, 2012
    Publication date: June 13, 2013
    Applicant: SEQUENOM, INC.
    Inventors: Mathias EHRICH, Anders Nygren
  • PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSES
    Publication number: 20130143211
    Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.
    Type: Application
    Filed: June 13, 2012
    Publication date: June 6, 2013
    Applicant: SEQUENOM, INC.
    Inventors: Mathias EHRICH, Anders Olof Herman Nygren
  • PROCESSES AND KITS FOR IDENTIFYING ANEUPLOIDY
    Publication number: 20130130923
    Abstract: Provided are methods for identifying the presence or absence of a chromosome abnormality by which a cell-free sample nucleic acid from a subject is analyzed. In certain embodiments, provided are methods for identifying the presence or absence of a fetal chromosome abnormality in a nucleic acid from cell-free maternal blood.
    Type: Application
    Filed: December 20, 2010
    Publication date: May 23, 2013
    Applicant: SEQUENOM, INC.
    Inventors: Mathias Ehrich, Guy Del Mistro, Cosmin Deciu, Yong Qing Chen, Ron Michael McCullough, Roger Chan Tim
  • PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSES
    Publication number: 20120277119
    Abstract: Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
    Type: Application
    Filed: June 13, 2012
    Publication date: November 1, 2012
    Applicant: SEQUENOM, INC.
    Inventors: Mathias EHRICH, Anders Olof Herman Nygren
  • RESTRICTION ENDONUCLEASE ENHANCED POLYMORPHIC SEQUENCE DETECTION
    Publication number: 20120270217
    Abstract: Provided in part herein is an improved method for the detection of specific polymorphic alleles in a mixed DNA population. The method comprises enriching the relative percentage of a given polymorphic allele that is exponentially amplifiable by PCR. Provided also are methods for selectively enriching target nucleic acid, for example, fetal nucleic acid in a maternal sample. In the case of detecting fetal nucleic acid in a maternal sample, a restriction enzyme is introduced that can discriminate between the alleles of a polymorphic site. In some embodiments, the maternal allele is digested and nucleic acid comprising the paternal allele is relatively enriched.
    Type: Application
    Filed: May 25, 2012
    Publication date: October 25, 2012
    Applicant: Sequenom, Inc.
    Inventors: Mathias EHRICH, Dirk Johannes Van Den Boom
  • METHOD FOR ACCURATE ASSESSMENT OF DNA QUALITY AFTER BISULFITE TREATMENT
    Publication number: 20120270224
    Abstract: The present invention is directed to methods useful for determining DNA quality after bisulfite treatment. The methods include a PCR-based assay, which allows ab-initio assessment of the DNA quality after bisulfite treatment and can help to prevent inaccurate quantitative measurement resulting from poor bisulfite treatment.
    Type: Application
    Filed: May 25, 2012
    Publication date: October 25, 2012
    Applicant: Sequenom, Inc.
    Inventor: Mathias EHRICH
  • NUCLEIC ACID-BASED TESTS FOR RHD TYPING, GENDER DETERMINATION AND NUCLEIC ACID QUANTIFICATION
    Publication number: 20120214680
    Abstract: The invention in part provides nucleic acid-based assays, which are particularly useful for non-invasive prenatal testing. The invention in part provides compositions and methods for RhD typing, detecting the presence of fetal nucleic in a sample, determining the relative amount of fetal nucleic acid in a sample and determining the sex of a fetus, wherein each of the assays may be performed alone or in combination.
    Type: Application
    Filed: December 12, 2011
    Publication date: August 23, 2012
    Applicant: SEQUENOM, INC.
    Inventors: Paul Andrew OETH, Mathias Ehrich
  • Restriction endonuclease enhanced polymorphic sequence detection
    Patent number: 8206926
    Abstract: Provided in part herein is an improved method for the detection of specific polymorphic alleles in a mixed DNA population. The method comprises enriching the relative percentage of a given polymorphic allele that is exponentially amplifiable by PCR. Provided also are methods for selectively enriching target nucleic acid, for example, fetal nucleic acid in a maternal sample. In the case of detecting fetal nucleic acid in a maternal sample, a restriction enzyme is introduced that can discriminate between the alleles of a polymorphic site. In some embodiments, the maternal allele is digested and nucleic acid comprising the paternal allele is relatively enriched.
    Type: Grant
    Filed: March 25, 2009
    Date of Patent: June 26, 2012
    Assignee: Sequenom, Inc.
    Inventors: Mathias Ehrich, Dirk Johannes Van den Boom