Abstract: A database management engine provides a user interface that allows users to access and modify employee information in a database. The database includes entries for employees, and each database entry includes identifying information about the associated employee. A user can request to modify data within database entries, for instance in order to update information associated with an employee. Responsive to the request, the database management engine identifies liabilities associated with the database modification stemming from associated tax laws. Based on the identified tax liabilities, the engine computes the aggregate tax liability owed by the employer and/or employee. Before modifying a database entry, the engine modifies the user interface to include interface elements detailing the computed aggregate tax liability. The user explicitly can be required to confirm the database modification in view of the aggregate tax liability.

Abstract: This invention relates to compositions and methods for the treatment of cancer, in particular difficult-to-treat cancers. More specifically, the present invention relates to compositions and methods for the treatment of PD-L1 negative or PD-L1 low expressing cancers using a modulator of ICOS, such as an anti-ICOS antibody, either alone or in combination with other agents, such as an anti-PD-L1 antibody.

Abstract: Filtering device for filtering cerebrospinal fluid are disclosed. An example filtering device may include a filter housing having an inlet for receiving cerebrospinal fluid from a patient and an outlet for returning filtered cerebrospinal fluid to the patient. The filter housing may include a plurality of layers coupled together and defining a fluid pathway therein between the inlet and the outlet. A filtering section may be defined within the filter housing along the fluid pathway. The filtering section may include a widened region of the fluid pathway that is configured to slow the passage of fluid therethrough.

Abstract: Emmacin-related substituted dihydropyrimidine compounds demonstrate potency at low concentrations and inhibit Methicillin-resistant S. aureus growth.

Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as activators from AMPK, pharmaceutical compositions containing such compounds and their use to treat, for example, heart failure or peripheral vascular disease.

Abstract: A compressor system includes a compression module having an inlet for receiving air; and a filter housing in fluid communication with the compression module. The filter housing is constructed to house a filter, the filter having a sealing feature disposed at a first end of the filter and having an engagement feature disposed at a second end of the filter opposite the first end. The filter housing includes a trap door constructed to contact the engagement feature, and constructed to drive the engagement feature in a direction parallel to an axis of the filter toward the sealing feature and urge the sealing feature into sealing engagement with the filter housing.

Abstract: Systems and methods for servicing vehicle messages utilizing a common communications infrastructure are provided. A method includes obtaining, by a vehicle computing system onboard an autonomous vehicle, a message including a cryptographic signature and contextual information, a request, or a command. The method includes determining an originating sender associated with the message based on the cryptographic signature and determining a message privilege for the message based on the originating sender. The originating sender is a process that generated the message. The method includes determining a response for the contextual information, the request, or the command based on the message privilege. The response is indicative of an acceptance or rejection of contextual information, an assignment of computing resources to a request, or an acceptance or rejection of a command. The method includes performing a vehicle action based on the response.

Abstract: A vapor delivery needle is provided that may include any of a number of features. One feature of the energy delivery probe is that it can apply condensable vapor energy to tissue, such as a prostrate, to shrink, damage, or denature tissues of the prostate. Methods associated with use of the energy delivery probe are also covered.

Abstract: Disclosed are some implementations of systems, apparatus, methods and computer program products for facilitating the authentication of computing system requests across tenants of at least one multi-tenant database system. Authentication is facilitated using a central registry that is accessible by and independent from the tenants of the multi-tenant database system.

Abstract: A vehicle has a pod carrier, a pod rotatably connected to the pod carrier, and an energy attenuating system (EAS) disposed between the pod and the pod carrier to attenuate forces associated with a deflection of the pod relative to the pod carrier. A method of operating an energy attenuating system (EAS) is provided for attenuating energy associated with movement between a pod and a pod carrier. The method includes providing a vehicle having a pod carrier and providing the pod carrier with an EAS configured in an undeflected state.

Abstract: Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and effector T cells, to stimulate the immune system of patients, including use in treating cancers. Methods of producing anti-ICOS antibodies, including species cross-reactive antibodies, using transgenic knock-out mice.

Abstract: According to examples there may be provided a method for classifying a capnogram, the method comprising: obtaining a breath waveform from a capnogram determining one or more transition points of the breath waveform, wherein the transition points comprise: a delta transition point between an expiratory baseline and an expiratory upstroke, a gamma transition point between an inspiratory downstroke and an inspiratory baseline, and an alpha transition point between the expiratory upstroke and an expiratory plateau; extracting features of the breath waveform using the transition points; and applying a trained machine learning model to the extracted features, wherein the trained machine learning model is configured to output a classification of the capnogram from the features.

Abstract: A connection node assembly for use in connecting an upper prefabricated building module to a lower module. Hollow vertical edge supports of the building modules have top and bottom connection parts. A connecting bolt can be passed through the top part of an upper vertical support in the upper building module and seated within the bottom part of that vertical support with the shank extending downward. The shank engages a threaded aperture in a connecting nut secured within the top part of a corresponding lower vertical support in the lower building module. Diaphragm plates sandwiched between the upper and lower vertical supports are used to tie horizontally placed modules together.

Abstract: In a cartridge device for analyzing a body liquid, a first member of the cartridge has two or more wells for performing assays, and a second member of the cartridge has a compartment for holding one or more disposable pipette tips.

Abstract: Securely loading digital blocks into memory for consumption by a processor. A method includes, at a memory protection shim, receiving a digital block and a manifest for the digital block. The manifest includes a transformation key for the digital block. The transformation key is configured to be used for at least one of validating the digital block or decrypting the digital block. The manifest is encrypted. The method further includes decrypting the manifest to obtain the transformation keys. The method further includes using the transformation keys to perform at least one of validating or decrypting the digital block. The method further includes retransforming the digital block using a memory protection shim ephemeral key to perform at least one of creating an authentication tag or encrypting the digital block. The method further includes storing the retransformed digital block in memory.

Abstract: A system and method for electronic document management including: creating an executable document object, wherein the executable document object comprises at least one programmable element; constructing an interaction schema object, wherein each interaction schema comprises: executable logic and a trigger as part of an inbound interaction schema or an outbound interaction schema that associates an external resource with the executable document object; and bundling the interaction schema object with the executable document object.

Abstract: A cutting board with one or more cut-out sections is provided. The cutting board includes at least one work surface and a frame that transitions from a first (e.g., closed, stowed) position to a second position in which the frame at least partially defines a cut-out for removably holding one or more containers. The work surface may be used to prepare food ingredients, which are easily transported to the one or more containers. When work is complete, the containers are removed and the frame is returned to the first position, in which the cutting board occupies less space than in the second position.

Abstract: A database system is operable to determine a query for execution. A disjunction of a plurality of conjunctive normal form (CNF) filtering predicates is determined based on filtering predicates of the query. An IO pipeline is generated based on the disjunction of the plurality of CNF filtering predicates that includes, based on applying at least one type of optimization, at least one shared IO element common to multiple ones of plurality of the CNF filtering predicates. The IO pipeline is executed in accordance with execution of the query to generate a filtered subset of a plurality of rows that each meet at least one of the plurality of CNF filtering predicates.

Abstract: An apparatus comprising a CPU core configured to execute instructions and consume data. The apparatus includes a memory configured to store the instructions and the data. A memory protection shim is coupled to the CPU core and the memory. The memory protection shim is configured to perform transformations over digital blocks to perform at least one of authentication or decryption of the digital blocks received from the memory. The memory protection shim is coupled to the CPU core in a fashion that prevents egress of the digital blocks or ingress of other external digital blocks between the memory protection shim and the CPU core.

Abstract: A durability assessment system may receive a request, from a computing system, for a durability index describing an entity. The durability assessment system may determine the durability index based on information about the resource usage by the entity, such as a resource availability score or a resource allocation score. The durability assessment system may compare the obtained resource availability score and resource allocation score to ranges associated with a set of durability indices. Based on the comparison, the durability assessment system may determine a durability index for the entity. The durability index may indicate an ability of the entity to return accessed resources. In some cases, the durability assessment system may provide the durability index to an allocation computing system that is configured to determine whether to grant access to resources based on the durability index.