Abstract: The present disclosure provides compositions and methods for the genetic modification of cells, including, but not limited to, hepatocytes. The compositions and methods can comprise lipid nanoparticles, wherein the lipid nanoparticles comprise at least one bioreducible ionizable cationic lipid, at least one structural lipid, at least one phospholipid and at least one PEGylated lipid.

Abstract: A database system receives a query. The database system retrieves an old query execution plan (QEP), OldPlan, for the query. The database system submits the query to an optimizer. The optimizer returns a new QEP, NewPlan, for the query. The database system submits the OldPlan and the NewPlan to a machine learning classifier (ML classifier). The ML classifier predicts that executing the NewPlan will result in a performance regression as compared to executing the OldPlan. The database system executes the OldPlan instead of the NewPlan.

Abstract: A steering wheel actuation device, for example in ADAS testing, is provided. The actuation device can include a steering wheel actuator to selectively move during testing between an engaged configuration and a disengaged configuration. The actuation device can impart an actuation force to a vehicle steering wheel in the engaged configuration, and can vary the magnitude of the resistance it creates to the turning of the steering wheel during testing.

Abstract: Systems and methods for cultivating or accumulating climate-focused marine target products are described herein. The target product may be microalgae, macroalgae, plankton, marine bacteria or archaea, filter feeders (such as oysters or clams), or crustaceans either for the purpose of bioremediation, eventual cultivation or for sequestering carbon dioxide; or the target product may be direct chemical or biological accumulation of carbon or carbon containing organisms. The system is primarily a floating apparatus designed to hold the target product in a region of the water column and in a spatial region of the water where it will best accumulate target product mass. In some embodiments the system is designed to achieve eventual passive sinking (transformation from a floating to sinking apparatus) into the deep ocean. In some embodiments, the system is equipped with purpose-chosen sensors to instrument and quantify the various biological and mechanical processes occurring onboard.

Abstract: A method of targeting, which involves capturing a first video of a scene about a potential targeting coordinate by a first video sensor on a first aircraft; transmitting the first video and associated potential targeting coordinate by the first aircraft; receiving the first video on a first display in communication with a processor, the processor also receiving the potential targeting coordinate; selecting the potential targeting coordinate to be an actual targeting coordinate for a second aircraft in response to viewing the first video on the first display; and guiding a second aircraft toward the actual targeting coordinate; where positive identification of a target corresponding to the actual targeting coordinate is maintained from selection of the actual targeting coordinate.

Abstract: Aspects of the disclosure relate to cash handling devices that provide intelligent monitoring and management of cash cycles. A cash handling device having at least one processor, a communication interface, and memory may receive, from a mobile device, a request to process a pre-staged transaction. Subsequently, the cash handling device may generate and present a graphical identifier based on the mobile device requesting access to the cash handling device. Next, the cash handling device may verify that the mobile device is authorized to perform the pre-staged transaction based on the graphical identifier being scanned by the mobile device and cause a connection to be established between the cash handling device and the mobile device. Thereafter, the cash handling device may identify and process the pre-staged transaction associated with the mobile device. Then, the cash handling device may generate a notification indicating completed processing of the identified pre-staged transaction.

Abstract: Data distribution and analysis systems, and associated methods are described herein. In one aspect, a method for distributing data can include: receiving, by a computing service and from a medical data server, medical image data stored by the PACS; inputting the medical image data into a machine learning model hosted by the computing service, wherein the computing service allows users to upload machine learning models and configure corresponding machine learning models to interface with the medical data server; generating, by the machine learning model, additional biometric data corresponding to the medical image data; and sending the additional biometric data to the medical data server, wherein the additional biometric data and the medical image data is incorporated into an electronic health record (EHR).

Abstract: Systems, computer program products, and methods are described herein for activity data transmission in real-time using alternative communication rails to skip processing touch points. Specifically, the systems, apparatuses, methods and computer program products of the present invention are directed to a secure platform for preemptive transformation and structuring of resource data at a resource instrument device and authentication of resource data for processing from the resource instrument device to an end point party in real time without requiring intermediary processing.

Abstract: A panel system includes a chassis holding one or more tray arrangements, which are each configured to receive one or more cassettes at two or more bays. The tray arrangements and cassettes cooperate to define a cassette sensor arrangement and a port occupancy sensor arrangement having separate interface points. The cassette sensor arrangement may include electronic memory storing physical layer information about the cassette. All active components of the port occupancy sensor arrangement are disposed on the tray while the electronic memories of the cassette sensor arrangement are stored on the cassettes.

Abstract: A device for sealing an aperture in a tissue includes: a foot including a distal portion configured to be disposed distal to the tissue when the device is implanted in a position to seal the aperture; and a flexible wing positionable against a distal surface of the tissue adjacent the aperture such that the flexible wing is disposed between the distal portion of the foot and the distal surface adjacent the aperture.

Abstract: Described are substrate containers that are useful for holding or transporting substrates such as semiconductor wafers and microelectronic devices, in a clean environment, as well as methods of using the substrate containers.

Abstract: A rechargeable lithium-ion battery assembly configured to provide power to a forklift vehicle, the battery assembly including a plurality of battery modules integrated into the assembly, where each integrated battery module includes a plurality of battery cells within a module casing, with the cells being grouped and interconnected in both series and parallel to provide in combination an overall predetermined electrical potential between a positive terminal and a negative terminal for each module, and where each module uses two conductors within a printed circuit board assembly (PCBA) as busbars, with the PCBA being disposed adjacent to a first end of each battery cell in the module and being electrically coupled by wire bonds with each battery cell, and the PCBA also having a processor (a battery management system, or BMS) for management control of the integrated module.

Abstract: A method of generating customizable goal representation is disclosed. A request from a user to view a goal representation is received. A flexible goal ontology is accessed that comprises one or more goal entities, one or more goal relationships between the goal entities, or one or more goal properties, the one or more goal properties including one or more metadata attributes relating to the one or more goal entities. A set of mapping rules is obtained that defines mappings between one or more goals. The set of mapping rules is evaluated to assemble a customized goal representation tailored to the user. The customized goal representation is updated based on a revaluation of the mapping rules affected by changes to the one or more goal entities, the one or more goal relationships, or the one or more properties.

Abstract: A lidar system includes one or more light sources configured to generate a first beam of light and a second beam of light, a scanner configured to scan the first and second beams of light across a field of regard of the lidar system, and a receiver configured to detect the first beam of light and the second beam of light scattered by one or more remote targets. The scanner includes a rotatable polygon mirror that includes multiple reflective surfaces angularly offset from one another along a periphery of the polygon mirror, the reflective surfaces configured to reflect the first and second beams of light to produce a series of scan lines as the polygon mirror rotates. The scanner also includes a pivotable scan mirror configured to (i) reflect the first and second beams of light and (ii) pivot to distribute the scan lines across the field of regard.

Abstract: A method and device for reducing emissions of nitrogen oxides and for increasing heat transfer in a fired process heater is disclosed herein. The invention relates generally to the combustion of fuel using some proportion of air as the oxidant which leads to the production of oxides of nitrogen, and more particularly to a method and device that reduces the production of nitrogen oxides from combustion, promotes the appropriate distribution of temperature to reduce fouling of the process tubes in a fired heater, and increases the efficiency of heat transfer to the same process tubes.

Abstract: A fault insertion device (FID) comprises a transceiver and an FPGA. The transceiver receives signals from a MIL-STD-1553/1760 communications bus. The FPGA evaluates the signals received from the communications bus against a set of rules stored by the FPGA. Based upon the set of rules, the FPGA can selectively modify messages received from the communications bus prior to transmission to a remote terminal or a bus controller that is configured to communicate on the communications bus.

Abstract: An anti-cant indicator assembly, components thereof, and associated methods. The anti-cant indicator assembly indicates the orientation of a weapon with respect to vertical. The anti-cant indicator assembly includes a mount configured to mount to the weapon, a level including a vial containing a bubble and a pivot connection connecting the level to the mount. The pivot connection is configured to permit movement of the level with respect to the mount about the pivot connection between an operational position in which the bubble can be referenced by the user for indicating orientation of the weapon with respect to vertical, and a stowed position different from the operational position. The pivot connection can include a retainer configured to releasably retain the level in at least one of the operational position or the stowed position. The level can be selectively movable with respect to the mount to calibrate the anti-cant indicator.

Abstract: Techniques are discussed herein for detecting and measuring faults within vehicle drive systems. In various implementations, actuator feedback monitors and/or vehicle performance monitors are used individually or in combination to determine faults within acceleration systems, braking systems, and/or steering systems of a vehicle. Different monitors may use different algorithms, models, and input data from the vehicle during operation, to compare a predicted drive system output to a corresponding measured output. Additionally, monitors may include associated sets of disable conditions used to distinguish drive system faults from other driving conditions. The outputs from actuator feedback monitors, vehicle performance monitors, and disable conditions may be analyzed to detect drive system faults and control the vehicle to address the faults and control the safe operation of the vehicle.