Abstract: A system for enabling real-time iterative collaborative decision support. The system includes one or more processors and memory storing instructions for receiving a connection request from a client device; establishing a first connection with the client device, including populating a first user interface of the client device, wherein the first user interface corresponds to the first workspace; broadcasting availability of the client device to two or more coach devices; in response to the broadcast, receiving a connection request from a first coach device; and in response to receiving the connection request from the first coach device, establishing a second connection with the first coach device, including populating a second user interface of the first coach device, wherein the second user interface corresponds to the first workspace and includes an element not included in the first user interface of the client device.

Abstract: A mixing system for use in a process bottle for mixing its contents, the mixing system including a low volume magnetically-driven mixer mounted at the bottom of the bottle. The mixer may have vanes and lower grooves, or no vanes and grooves on both upper and lower faces. The mixer has a “microsized” three-dimensional solid inanimate body to enable insertion through relatively small mouth openings at the top of conventional reactor bottles. Methods of assembly are also disclosed which involve passing the microsized mixer through an open mouth of a process bottle and coupling the mixer with a bearing assembly at the floor of the bottle. The bearing assembly includes fixtures sealed around a hole in the floor of the bottle.

Abstract: The present invention is directed to a method, apparatus and computer-readable medium for utilizing a shared computer system. The method includes receiving, by way of at least one interface, an access request associated with a potential user of a financial entity for access to a secure data processing center of a financial regulatory system, wherein the secure data processing center is configured to share information associated with specified financial activities. The method includes determining a classification of the potential user with respect to one or more potential or actual access rights to be associated with the potential user for accessing the secure data processing center. The determined classification of the potential user is that the potential user is an eligible user of the secure data processing center as defined by an accrediting organization of the financial regulatory system.

Abstract: A display system for sensing a finger of a user applied to the display system includes a display panel; a sensor for sensing the finger; a sensing light source configured to emit a first light having a first wavelength W1; and a reflective polarizer disposed between the display panel and the sensor. For a substantially normally incident light, an optical transmittance of the reflective polarizer versus wavelength for a first polarization state has a band edge such that for a first wavelength range extending from a smaller wavelength L1 to a greater wavelength L2 and including W1, where 30 nm?L2?L1?50 nm and L1 is greater than and within about 20 nm of a wavelength L3 corresponding to an optical transmittance of about 50% along the band edge, the optical transmittance has an average of greater than about 75%.

Abstract: According to certain general aspects, the present embodiments relate generally to a device that mobilizes the lens material inside the capsular bag. Mobilized lens material is easier to visualize than lens material lingering at the lens equator of the eye, or other areas in the capsular bag that are difficult to visualize, making the mobilized lens material easier to retrieve from the capsular bag. Mobilizing the lens material reduces the possibility that the person receiving the cataract surgery will develop secondary cataracts or infections due to lens material left inside the capsular bag.

Abstract: A process heat exchange rod for cooling or heating liquids in a process vessel. The rod may have a linear form and extend downward through an upper wall of the process vessel into proximity with the lower floor. The rod internally defines a circulatory flow path for the heat exchange medium, including an outer jacket and a flow diverter having a central through bore and external helical flutes. Heat exchange medium travels down through the central through bore and then back up through helical grooves formed between the flow diverter and the outer jacket, or vice versa. Accurate heating or cooling of the process fluid is attained by modification of the configuration of the heat exchange rod as well as the flow rate and temperature of the heat exchange medium. The components may be injection molded of a polymer, often transparent, having a high heat transfer coefficient.

Abstract: The present invention is directed to a method, apparatus and computer-readable medium for utilizing a shared computer system. The method includes receiving, by way of at least one interface, an access request associated with a potential user of a financial entity for access to a secure data processing center of a financial regulatory system, wherein the secure data processing center is configured to share information associated with specified financial activities. The method includes determining a classification of the potential user with respect to one or more potential or actual access rights to be associated with the potential user for accessing the secure data processing center. The determined classification of the potential user is that the potential user is an eligible user of the secure data processing center as defined by an accrediting organization of the financial regulatory system.

Abstract: The present invention is directed to a method, apparatus and computer-readable medium for utilizing a shared computer system. The method includes receiving, utilizing at least one interface, an access request associated with a potential user for access to a secure data processing center. The method may also include processing, utilizing at least one processor, the access request. The system may also include determining, based on the processed access request, a classification of the potential user with respect to one or more potential or actual access rights to be associated with the potential user for accessing the secure data processing center. In the method, the determined classification of the potential user is that the potential user is at least one of a non-user, an eligible user, a limited user and an authorized user of the secure data processing center.

Abstract: Described here are systems and methods for performing magnetic resonance imaging (“MRI”) using radio frequency (“RF”) phase gradients to provide spatial encoding of magnetic resonance signals rather than the conventional magnetic field gradients. Particularly, the systems and methods described here implement swept RF pulses (e.g., wideband, uniform rate, and smooth transition (“WURST”) RF pulses) and a quadratic phase correction to enable RF phase gradient encoding in inhomogeneous background (B0) magnetic fields.

Abstract: A system and method of use includes (a) directing a magnetic resonance (MR) system to perform a pulse sequences block in which radio frequency (RF) energy is applied to the subject to substantially saturate magnetization corresponding to an exchangeable proton. The method includes (b), following step (a), acquiring data from the subject with the MR system and (c) repeating step (a) a plurality of times where parameters of the pulse sequence sub-block differ in at least some pulse sequence sub-blocks by at least an amount of RF energy applied to saturate the magnetization. The method further includes (d), after each repetition of step (a), repeating step (b) to acquire data representing signal evolutions from the subject. Additionally, the method includes (e) comparing the signal evolutions with a dictionary database comprising a plurality of different signal evolution templates to determine quantitative chemical exchange or exchangeable proton information of the subject.

Abstract: A system and method for imaging in connection with electrical currents includes nanoparticles introduced into a region in which the electrical currents are present. A low-field magnetic resonance imaging (MRI) scanner detects an effect of a magnetic field generated by interaction of the nanoparticles with the electrical currents in the region. The MRI scanner operates at a magnetic field intensity below a level at which the nanoparticles would be magnetically saturated.

Abstract: Systems and methods for magnetic resonance fingerprinting (“MRF”) using highly differentiated trajectories that optimize differentiation between magnetic resonance signal patterns as a function of relaxation time(s) and static magnetic field homogeneity are described. Using the optimized acquisition parameters, MRF can be performed in the presence of inhomogeneous magnetic fields. Flip angle homogeneity can also be incorporated into the dictionary matching process to simultaneously estimate quantitative parameters of the subject and radio frequency coil transmission homogeneity profiles.

Abstract: Described here are systems and methods for performing magnetic resonance imaging (“MRI”) using radio frequency (“RF”) phase gradients to provide spatial encoding of magnetic resonance signals rather than the conventional magnetic field gradients. Particularly, the systems and methods described here implement swept RF pulses (e.g., wideband, uniform rate, and smooth transition (“WURST”) RF pulses) and a quadratic phase correction to enable RF phase gradient encoding in inhomogeneous background (B0) magnetic fields.

Abstract: A system and method for imaging in connection with electrical currents includes nanoparticles introduced into a region in which the electrical currents are present. A low-field magnetic resonance imaging (MRI) scanner detects an effect of a magnetic field generated by interaction of the nanoparticles with the electrical currents in the region. The MRI scanner operates at a magnetic field intensity below a level at which the nanoparticles would be magnetically saturated.

Abstract: A system and method of use includes (a) directing a magnetic resonance (MR) system to perform a pulse sequences block in which radio frequency (RF) energy is applied to the subject to substantially saturate magnetization corresponding to an exchangeable proton. The method includes (b), following step (a), acquiring data from the subject with the MR system and (c) repeating step (a) a plurality of times where parameters of the pulse sequence sub-block differ in at least some pulse sequence sub-blocks by at least an amount of RF energy applied to saturate the magnetization. The method further includes (d), after each repetition of step (a), repeating step (b) to acquire data representing signal evolutions from the subject. Additionally, the method includes (e) comparing the signal evolutions with a dictionary database comprising a plurality of different signal evolution templates to determine quantitative chemical exchange or exchangeable proton information of the subject.

Abstract: The present invention is directed to a method, apparatus and computer-readable medium for utilizing a shared computer system. The method includes receiving, utilizing at least one interface, an access request associated with a potential user for access to a secure data processing center. The method may also include processing, utilizing at least one processor, the access request. The system may also include determining, based on the processed access request, a classification of the potential user with respect to one or more potential or actual access rights to be associated with the potential user for accessing the secure data processing center. In the method, the determined classification of the potential user is that the potential user is at least one of a non-user, an eligible user, a limited user and an authorized user of the secure data processing center.

Abstract: The present invention is directed to a system for rapid enrollment of users of a secure, shared computer system comprising: (a) a secure shared computer system accessible only by approved users; (b) a plurality of approved users of the secure shared computer system; (c) a system manager that operates the secure shared computer system; (d) a plurality of member organizations, wherein the member organizations purchase a right to allow employees or members of the member organizations to be approved users of the shared computer system from the system manager; (e) at least one email system operated by each member organization which the employees or members of the member organizations use to receive and send email, where access to email sent to each individual employee or member is securely limited to that individual; (f) at least one accrediting organization, wherein the at least one accrediting organization registers member organizations and grants rights for employees or members of the member organizations, indi

Abstract: Systems and methods for magnetic resonance fingerprinting (“MRF”) using highly differentiated trajectories that optimize differentiation between magnetic resonance signal patterns as a function of relaxation time(s) and static magnetic field homogeneity are described. Using the optimized acquisition parameters, MRF can be performed in the presence of inhomogeneous magnetic fields. Flip angle homogeneity can also be incorporated into the dictionary matching process to simultaneously estimate quantitative parameters of the subject and radio frequency coil transmission homogeneity profiles.

Abstract: The present invention is directed to a system for rapid enrollment of users of a secure, shared computer system comprising: (a) a secure shared computer system accessible only by approved users; (b) a plurality of approved users of the secure shared computer system; (c) a system manager that operates the secure shared computer system; (d) a plurality of member organizations, wherein the member organizations purchase a right to allow employees or members of the member organizations to be approved users of the shared computer system from the system manager; (e) at least one email system operated by each member organization which the employees or members of the member organizations use to receive and send email, where access to email sent to each individual employee or member is securely limited to that individual; (f) at least one accrediting organization, wherein the at least one accrediting organization registers member organizations and grants rights for employees or members of the member organizations, indi

Abstract: The invention concerns processes for the synthesis of a compound of the formula: wherein: R1 and R2 are each, independently, C1-C12 alkyl, CO2R3, OR4, R5(OR6), or C6-C18 aryl; R3-R6 are each, independently, C1-C12 alkyl or C6-C12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R7-0H with BH3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R7 is a C2-C12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.