Abstract: An open loop cashless payment system incents a consumer account holder to transact in a physical store with a merchant who agrees to make an auditable donation to a charity when the transaction is conducted on an account issued to the consumer account holder. The consumer account holder may direct the donation to a specific charity within a predetermined geographically determined community where the transaction was physically conducted. The consumer account holder can register an obligation to make a donation matching that of the merchant, where the consumer account holder's donation is initially paid by the consumer account's issuer for reimbursement by the consumer account holder to the issuer after the consumer account holder receives their account statement. The merchant's acquirer, the issuer, and a transaction handler for the issuer and acquirer may also make donations as directed by the consumer account holder.

Abstract: Links are generated between local merchants and community programs for merchant incentives to customers for the programs which are tracked for online-offline customer transactions using incentives. Participants' identifiers are linked to payment sources. Offline-online transaction data is collected in a data storage area. All data in the data storage area may be utilized by logic tool, which may provide information, such as details of consumer behavior and analytic reporting. Rich data provided by pre-transaction chat sessions between merchants and potential customers are matched with rich data provided by subsequent transactions between the merchants and their customers, and a level of certainty may be determined as to the accuracy of the match of a prior chat session to a subsequent transaction.

Abstract: Methods, devices and media for a pre-enrollment registration system are described.

Abstract: Methods, systems and device for verifying a transaction in a loyalty or advertising system are described. One such method includes: receiving, at least one processor, transaction data associated with a transaction between a customer and a merchant; determining, at the at least one processor, from the transaction data whether the customer and the merchant are associated with the loyalty or advertising system; and upon determining from the transaction data whether the transaction corresponds to a reward or advertisement, triggering the redemption of the reward or advertisement.

Abstract: The generating of actionable recommendations for tuning model metrics of an Artificial Intelligence (AI) system includes partitioning a key performance indicator (KPI) range associated with a target system into a plurality of buckets. Log data including at least one KPI of the target system and one or more AI model metrics is partitioned and distributed across the plurality of buckets. For each bucket, an aggregate value of the one or more AI model metrics across the log data is computed and weighted according to the volume of log data in that bucket. A correlation factor between the aggregate value and a representative KPI value for each bucket is determined. A model tuning recommendation to increase ranking of the AI model metrics according to the determined correlation factor is provided to an output device and/or to the AI system for updating the one or more AI model.

Abstract: The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds of Formula (I) to pharmaceutical compositions comprising compounds of Formula (I) and to methods of use thereof, such as methods of treating cancer using the compounds of Formula (I) and pharmaceutical compositions comprising those compounds.

Abstract: The present invention relates to compounds that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Abstract: The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds of Formula (I) to pharmaceutical compositions comprising compounds of Formula (I) and to methods of use thereof, such as methods of treating cancer using the compounds of Formula (I) and pharmaceutical compositions comprising those compounds.

Abstract: Compounds that inhibit KRas G12D; in particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are compounds that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, disclosed are compounds of Formula (I) and pharmaceutical compositions thereof, and methods of using the compounds and pharmaceutical compositions in, for example, methods of treating cancer.

Abstract: Methods, devices and media for a pre-enrollment registration system are described.

Abstract: Disclosed are compounds of formula (I) or (II) that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Abstract: Methods, systems and computer program products for improving ground truth quality for modeling are provided. Aspects include receiving a plurality of data inputs, wherein each of the plurality of data inputs has an associated label. Aspects also include training a model based on the plurality of data inputs. Aspects also include generating a plurality of vector representations corresponding to the plurality of data inputs based on the model. Aspects also include clustering the plurality of vector representations into one or more clusters. Aspects also include identifying at least one anomalous data input based on the one or more clusters. The at least one anomalous data input can be a data input of the plurality of data inputs that is mislabeled, contributes to an ambiguous class structure or is an outlier. Aspects also include outputting a notification that provides an indication of the at least one anomalous data input.

Abstract: The present invention relates to compounds that inhibit at least one of KRas wild type, KRas G12A, KRas G12C, KRas G12D, KRas G12R, KRas G12S, KRas G12V, KRas G13D and KRas Q61H, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: A donor incentivizes a payer to make a real time payment to a payee, as facilitated by operation of one RTPS Technology, by terms set by the donor to make an auditable donation to an affinity entity designated by the payer. To incent such real time payments within a predetermined geographic location, the donor's terms may limit its donation by a derivation of navigation time between the payer and payee, and/or by date and time of the real time payment from the payer to the payee. The payer can direct the donation by the donor to one of more affinity entities within the payer's own geographic community, and/or within a community where the real time payment was physically conducted. An payer can also make a donation to the affinity entity at the time of real time payment by the payer where the donation by the payer is paid by a payer financial institution that issued a payer account of the payer.

Abstract: Methods, systems and device for verifying a transaction in a loyalty or advertising system are described. One such method includes: receiving, at least one processor, transaction data associated with a transaction between a customer and a merchant; determining, at the at least one processor, from the transaction data whether the customer and the merchant are associated with the loyalty or advertising system; and upon determining from the transaction data whether the transaction corresponds to a reward or advertisement, triggering the redemption of the reward or advertisement.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: Systems, data access management utilities, and methods generate links between local merchants and community programs, whereby the merchant may provide incentives to customers in relation to community programs. The implementations may track community programs, as well as online and offline customer transactions with merchants that make use of the incentive. Implementations may include as participants, customers, merchants, community organizations, intermediaries, and other groups or individuals. Participants may have participant identifiers, which may be linked to a payment source. Data may be collected about all participants, either expressly, or from offline or online transactions between merchants and customers utilizing a participant identifier, and the data may be stored in a data storage area.

Abstract: The present disclosure relates to compounds of Formula (I), or pharmaceutically, acceptable salts thereof, that inhibit Polycomb Repressive Complex 2 (PRC2) activity. In particular, the present disclosure relates to compounds, or pharmaceutically acceptable salts thereof pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions comprising compounds of Formula (I), or pharmaceutically acceptable salts thereof.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.