Patents by Inventor Matthew C. Stevens

Matthew C. Stevens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bryostatin compounds and methods of preparing the same
    Patent number: 11746105
    Abstract: Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: September 5, 2023
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Paul Wender, Ryan Quiroz, Stephen Ho, Akira Shimizu, Steven Ryckbosch, Matthew C. Stevens, Matthew S. Jeffreys, Clayton Hardman, Jack Sloane
  • BRYOSTATIN COMPOUNDS AND METHODS OF PREPARING THE SAME
    Publication number: 20210292309
    Abstract: Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.
    Type: Application
    Filed: January 29, 2021
    Publication date: September 23, 2021
    Inventors: Paul Wender, Ryan Quiroz, Stephen Ho, Akira Shimizu, Steven Ryckbosch, Matthew C. Stevens, Matthew S. Jeffreys, Clayton Hardman, Jack Sloane
  • Bryostatin compounds and methods of preparing the same
    Patent number: 10947221
    Abstract: Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: March 16, 2021
    Assignee: The Board of the Leland Stanford Junior University
    Inventors: Paul Wender, Ryan Quiroz, Stephen Ho, Akira Shimizu, Steven Ryckbosch, Matthew C. Stevens, Matthew S. Jeffreys, Clayton Hardman, Jack Sloane
  • BRYOSTATIN COMPOUNDS AND METHODS OF PREPARING THE SAME
    Publication number: 20190292172
    Abstract: Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.
    Type: Application
    Filed: September 28, 2017
    Publication date: September 26, 2019
    Inventors: Paul Wender, Ryan Quiroz, Stephen Ho, Akira Shimizu, Steven Ryckbosch, Matthew C. Stevens, Matthew S. Jeffreys, Clayton Hardman, Jack Sloane