Abstract: A reciprocating saw blade includes an elongated blade body extending along a blade axis and having a rear end, a front end, a cutting edge having a plurality of teeth, a non-cutting edge opposite the cutting edge; and a tang coupled to the rear end and configured to be received in a blade holder of a powered reciprocating saw. The cutting edge includes inclined and declined cutting edge portions. The inclined cutting edge portion extends away from the blade axis and toward the front end at an acute first angle and extends from a first tooth to a second tooth. The first tooth is closer to the rear end and closer to the blade axis than the second tooth. The declined cutting edge portion extends toward the blade axis and toward the front end at an acute second angle that is greater than the first angle and extends from a third tooth to the first tooth. The first tooth is closer to the front end and closer to the blade axis than the third tooth.

Abstract: A hole cutting accessory for a power-driven tool may include an arbor that provides for quick release of an annular saw blade component of the accessory, and for quick release of a pilot drill bit component of the accessory. The quick release of the annular saw blade component from the arbor may be accomplished separately from the quick release of the pilot drill bit component from the arbor.

Abstract: An apparatus for installing multiple strands of hose below a surface of terrain is provided. The apparatus comprises a chassis and rotating trenching blade assemblies connected to the chassis. The trenching blade assemblies are configured to dig parallel trenches when the apparatus is pulled along the terrain. Curved hose guides are connected to the chassis in trailing positions behind the trenching blades. Each hose guide receives hose from a hose reel on reel mounts connected to the chassis and deposits the hose into a trench dug by a trenching blade assembly. Trench fillers connected to the chassis trail the hose guides. Each trench filler is aligned with a respective hose guide and comprises a number of blades configured to push soil excavated from a trench back into the trench when the apparatus is pulled along the terrain.

Abstract: A method includes monitoring and logging a plurality of transactions between one or more clients and an application programming interface gateway, and analyzing data corresponding to the plurality of transactions using one or more machine learning techniques. The method further includes determining, based on the analyzing, one or more issues corresponding to one or more application programming interfaces associated with the application programming interface gateway and resulting from one or more of the plurality of transactions. In the method, one or more corrective actions are performed to address the one or more issues.

Abstract: The invention is directed to a method of increasing the expression of Activity-Dependent Neuroprotector Protein (ADNP) in at least one mammalian cell showing insufficient ADNP expression levels, comprising administering to the at least one mammalian ceil an effective amount of ketamine or a combination of ketamine and ADNP-Derived Neuroprotective Peptide (NAP).

Abstract: An accessory includes an attachment portion with a central opening configured to be coupled to an oscillating power tool and defining a first axis generally parallel to a power tool axis. An intermediate portion with a first side edge and a second side edge has a proximal end portion coupled to the attachment portion and extends away from the attachment portion to a distal end portion. A working portion is coupled to and extends away from a distal end portion at an angle to the intermediate portion and at an angle to the first axis. The working end portion has a non-cutting third side edge continuous with the first side edge and a cutting fourth side edge continuous with the second side edge. The intermediate portion wraps at least partially around an obstruction located along the first axis so the working portion can cut a workpiece located behind the obstruction.

Abstract: An apparatus for installing multiple strands of hose below a surface of terrain is provided. The apparatus comprises a chassis and rotating trenching blade assemblies connected to the chassis. The trenching blade assemblies are configured to dig parallel trenches when the apparatus is pulled along the terrain. Curved hose guides are connected to the chassis in trailing positions behind the trenching blades. Each hose guide receives hose from a hose reel on reel mounts connected to the chassis and deposits the hose into a trench dug by a trenching blade assembly. Trench fillers connected to the chassis trail the hose guides. Each trench filler is aligned with a respective hose guide and comprises a number of blades configured to push soil excavated from a trench back into the trench when the apparatus is pulled along the terrain.

Abstract: Embodiments are directed to managing data in a file system that includes a plurality of storage nodes and a plurality of storage volumes such that each storage node may be a compute instance provided by a cloud computing environment (CCE) and each storage volume may be based on blobs provided by the CCE. Write requests that include write data may be provided. A lowest range of addresses in the storage volume may be determined for storing the write data. Buckets may be determined based on the range of addresses and the write data assigned to the buckets. If portions of the buckets remain unassigned, other data may be provided from a cache volume or the blobs. The write data and the other data may be written to the portion of the blobs.

Abstract: A heat exchanger of a heating, ventilation, air conditioning, and refrigeration (HVAC&R) system includes a plurality of microchannel tubes, where each microchannel tube of the plurality of microchannel tubes is configured to direct refrigerant therethrough, and a plurality of fin sets, where each fin set of the plurality of fin sets is disposed between corresponding adjacent microchannel tubes of the plurality of microchannel tubes. Additionally, each fin set of the plurality of fin sets includes a respective fin density based on a location of the respective fin set along a height of the heat exchanger.

Abstract: The instant invention provides compounds of formulas Ia and Ib which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.

Abstract: A medical device holder includes a one-piece holder body having end walls, and side walls, extending vertically upward from a base. The end walls are oriented parallel to one another, and the first and the second side walls are oriented so as to converge toward one another in a direction of an opening. A plurality of medical device storage slots are formed by a plurality of internal vertical walls, and a plurality of elongate medical devices wound in opposition to an internal unwinding bias are trapped within the plurality of medical device storage slots.

Abstract: A hole cutter has a cylindrical blade body including a cutting edge and one or more axially-elongated apertures formed within a side wall of the blade body. The axially-elongated aperture is configured to receive a lever, such as a screwdriver, therethrough. Each axially-elongated aperture includes a first fulcrum axially spaced adjacent to the cutting edge, a second fulcrum axially spaced further away from the cutting edge than the first fulcrum, and optionally a third fulcrum axially spaced between the first and second fulcrums. A lever, such as a screwdriver, can be inserted into the aperture and placed against each of the fulcrums to lever slugs out of the interior of the blade body.

Abstract: Processes for reviewing and editing a computer-generated animation are provided. In one example process, multiple images representing segments of a computer-generated animation may be displayed. In response to a selection of one or more of the images, geometry data associated with the corresponding segment(s) of computer-generated animation may be accessed. An editable geometric representation of the selected segment(s) of computer-generated animation may be displayed based on the accessed geometry data. In some examples, previously rendered representations and/or geometric representations of the same or other segments of the computer-generated animation may be concurrently displayed adjacent to, overlaid with, or in any other desired manner with the displayed geometric representation of the selected segment's) of computer-generated animation.

Abstract: This application discloses systems and methods of applying vibration to a targeted area on an individual that is experiencing pain, discomfort, or other musculoskeletal symptoms. Steps of the method include lengthening followed by oscillation and vibration. The lengthening step requires positioning the individual (e.g., with the help of a stretching cage) such that the individual experiences a stretching sensation in a targeted area (e.g., a group of muscles, ligaments, tendons, etc.). Next, the individual oscillates in and out of that lengthened position while vibration is applied to the targeted area. It has been discovered that these techniques can bring about dramatic and quick improvements in flexibility and range of motion, while also diminishing symptoms like pain and discomfort.

Abstract: A hole cutter has a cylindrical blade body including a cutting edge and one or more axially-elongated apertures formed within a side wall of the blade body. The axially-elongated aperture is configured to receive a lever, such as a screwdriver, therethrough. Each axially-elongated aperture includes a first fulcrum axially spaced adjacent to the cutting edge, a second fulcrum axially spaced further away from the cutting edge than the first fulcrum, and optionally a third fulcrum axially spaced between the first and second fulcrums. A lever, such as a screwdriver, can be inserted into the aperture and placed against each of the fulcrums to lever slugs out of the interior of the blade body.

Abstract: Computer implemented systems and methods for adjudication of treatments and prescriptions for a patient are provided. The method may comprise receiving a request to approve a medical request for administering a treatment to a patient; accessing a database of genetic information to determine genetic information of the patient; comparing the genetic information of the patient against a database of pharmacogenetic information in view of the medical request; and providing a response to the medical request, the response including one or more of administering the treatment to the patient, or offering an alternate treatment for the patient.

Abstract: An accessory for an oscillating power tool includes an attachment portion configured to be coupled to an oscillating power tool and a working portion coupled to the attachment portion and extending generally along a longitudinal axis. The working portion has a generally planar wedge shape bounded at least partially by a rear non-cutting end with a first width, a front cutting edge opposite the rear edge with a second width that is greater than the first width, a first side cutting edge extending from a first end of the rear end to a first end of the front cutting edge at a first angle to the longitudinal axis, and a second side cutting edge opposite the first side cutting edge and extending from a second end of the rear end to a second end of the front cutting edge at a second angle to the longitudinal axis.

Abstract: Processes for reviewing and editing a computer-generated animation are provided. In one example process, multiple images representing segments of a computer-generated animation may be displayed. In response to a selection of one or more of the images, geometry data associated with the corresponding segment(s) of computer-generated animation may be accessed. An editable geometric representation of the selected segment(s) of computer-generated animation may be displayed based on the accessed geometry data. In some examples, previously rendered representations and/or geometric representations of the same or other segments of the computer-generated animation may be concurrently displayed adjacent to, overlaid with, or in any other desired manner with the displayed geometric representation of the selected segment(s) of computer-generated animation.

Abstract: This application discloses systems and methods of applying vibration to a targeted area on an individual that is experiencing pain, discomfort, or other musculoskeletal symptoms. Steps of the method include lengthening followed by oscillation and vibration. The lengthening step requires positioning the individual (e.g., with the help of a stretching cage) such that the individual experiences a stretching sensation in a targeted area (e.g., a group of muscles, ligaments, tendons, etc.). Next, the individual oscillates in and out of that lengthened position while vibration is applied to the targeted area. It has been discovered that these techniques can bring about dramatic and quick improvements in flexibility and range of motion, while also diminishing symptoms like pain and discomfort.

Abstract: Various implementations include a wearable audio device for enhancing the acoustic response proximate a user, for example, in the direction of the user's mouth. In particular implementations, a wearable audio device includes: a head mount having: a crown portion for resting on a head of a user, and a brim extending from the crown portion in a forward-oriented direction; and a plurality of microphones coupled to the brim of the head mount.