Patents by Inventor Matthew D. Hilton

Matthew D. Hilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for removing N-terminal dipeptides from precursor polypeptides with dipeptidylaminopeptidase from Dictyostelium discoideum
    Patent number: 5565330
    Abstract: A method for removing dipeptides from the amino terminus of precursor polypeptides to produce a polypeptide product is presented which comprises contacting the precursor polypeptide for sufficient time to remove the dipeptide with a dipeptidylaminopeptidase (dDAP) from the slime mold, Dictyostelium descoideum, which has a mass of about 225 kilodaltons and a pH optimum of about 3.5. The precursor polypeptides may be made recombinantly and may be analogs of naturally occurring polypeptides.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: October 15, 1996
    Assignee: Eli Lilly and Company
    Inventors: Paul R. Atkinson, Matthew D. Hilton, Peter K. Lambooy
  • Dictyostelium dipeptidylaminopeptidase
    Patent number: 5565349
    Abstract: A dipeptidylaminopeptidase (dDAP enzyme) and a method for isolating it from the culture medium of the cellular slime mold, Dictyostelium discoideum have been presented. The isolated dDAP enzyme has a pH optimum of about 3.5 and a mass of about 225 kDA. The dDAP enzyme has an activity which is somewhat similar to both DAP-I and DAP-III from this organism. Methods for using the dDAP enzyme to remove dipeptides from the N-terminus of recombinantly produced precursor proteins or peptides are also presented.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: October 15, 1996
    Assignee: Eli Lilly and Company
    Inventors: Paul R. Atkinson, Matthew D. Hilton, Peter K. Lambooy
  • Microorganism ATCC53716 and process for producing acetophenone
    Patent number: 4871668
    Abstract: A microorganism of the genus Pseudomonas (ATCC 53716) metablizes cinnamate to produce acetophenone in a receoverable quantity upon fermentation in an aqueous nutrient medium containing cinnamate as a carbon source and, optionally, assimilable sources of nitrogen and inorganic substances.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: October 3, 1989
    Assignee: Pitman-Moore, Inc.
    Inventors: Matthew D. Hilton, Wendy J. Cain