Patents by Inventor MATTHEW DIRCKX
MATTHEW DIRCKX has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230270842Abstract: Microneedle and microneedle devices including implantable tips (e.g., silk-based tips) for sustained dermal delivery of a coronavirus and/or influenza vaccine, kits, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for controlled- or sustained-administration of a coronavirus vaccine and/or an influenza vaccine to provide improved immunogenicity and/or broad-spectrum immunity to a subject are also described.Type: ApplicationFiled: November 21, 2022Publication date: August 31, 2023Applicant: VAXESS TECHNOLOGIES, INC.Inventors: Michael A. Schrader, Kathryn M. Kosuda, Jonathan A. Kluge, Kimberly M. Cirelli, Emily L. Borkowski, Cassie L. Caudill, Matthew Dirckx, Nickolas W. Hartman, Livio Valenti
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Publication number: 20220339416Abstract: Microneedle and microneedle devices including, e.g., silk fibroin-based microneedles tips for sustained dermal delivery of an anti-cancer agent and/or an immunomodulatory agent, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for burst-release or sustained-release administration of an anti-cancer agent and/or an immunomodulatory agent to provide an improved immune response to a cancer in a subject are described.Type: ApplicationFiled: April 5, 2022Publication date: October 27, 2022Applicant: VAXESS TECHNOLOGIES, INC.Inventors: Kathryn M. Kosuda, Kimberly M. Cirelli, Alexander Beliveau, Archana V. Boopathy, Matthew Dirckx, Jonathan A. Kluge, Michael A. Schrader, Megan Eisele
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Patent number: 11253853Abstract: Fluidic devices and methods are provided.Type: GrantFiled: March 18, 2019Date of Patent: February 22, 2022Assignee: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Jason Taylor, Vincent Linder
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Publication number: 20210283597Abstract: The present invention generally relates to the collection, storage, and stabilization of biological samples (e.g., bodily fluids, such as whole blood, blood serum, and blood plasma), and analytes thereof. More particularly, the present invention relates to polymer-based biological sample collection devices, and methods of making and using the same.Type: ApplicationFiled: January 25, 2021Publication date: September 16, 2021Applicant: VAXESS TECHNOLOGIES, INC.Inventors: Jonathan A. Kluge, Alexander Beliveau, Adrian Benton Li, Matthew Dirckx, Michael A. Schrader, Kathryn M. Kosuda, Elizabeth Whitney Johansen
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Publication number: 20210085598Abstract: Microneedle and microneedle devices including implantable silk-based tips for sustained dermal delivery of a vaccine, kits, as well as methods of manufacturing and using the same are described herein. In other embodiments, compositions and methods for controlled- or sustained-administration of a vaccine (e.g., an influenza vaccine) to provide improved immunogenicity and/or broad-spectrum immunity to a subject are also described.Type: ApplicationFiled: April 2, 2019Publication date: March 25, 2021Inventors: Kathryn M. Kosuda, Jordan A. Stinson, Archana V. Boopathy, Matthew Dirckx, Jonathan A. Kluge, Yichen Zhang, Carter R. Palmer, Michael A. Schrader
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Publication number: 20210015413Abstract: Articles and methods for collecting and/or facilitating transfer of fluids are generally provided. In some embodiments, an article comprises a fluid collection region for introducing a fluid, such as a sample (e.g., blood sample) or a reagent, into a fluidic system. The articles and methods described herein may be useful for facilitating the filling of relatively small channels with a fluid, such as channels of a microfluidic device. The articles and methods may, for example, interface with a patient sample (e.g., a droplet of blood), or with a macroscopic fluid source such as a pipette or syringe. In certain embodiments, articles and methods described herein may increase the ease of collecting a fluidic sample from a patient, prevent or reduce spillage of the fluidic sample, reduce contamination of a fluidic sample, and/or prevent or reduce air from entering a fluidic sample or device compared to certain existing fluid collection devices.Type: ApplicationFiled: October 2, 2020Publication date: January 21, 2021Applicant: OPKO Diagnostics, LLCInventors: Jason Taylor, Hardeep Singh, Matthew Dirckx
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Patent number: 10852310Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may comprise an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In some embodiments, fluidic devices for performing a vitamin D assay are provided.Type: GrantFiled: December 8, 2016Date of Patent: December 1, 2020Assignee: OPKO Diagnostics, LLCInventors: Douglas M. Haddad, Gary J. Fagan, Yi Dong, Matthew Dirckx, Vincent Linder
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Patent number: 10827966Abstract: Articles and methods for collecting and/or facilitating transfer of fluids are generally provided. In some embodiments, an article comprises a fluid collection region for introducing a fluid, such as a sample (e.g., blood sample) or a reagent, into a fluidic system. The articles and methods described herein may be useful for facilitating the filling of relatively small channels with a fluid, such as channels of a microfluidic device. The articles and methods may, for example, interface with a patient sample (e.g., a droplet of blood), or with a macroscopic fluid source such as a pipette or syringe. In certain embodiments, articles and methods described herein may increase the ease of collecting a fluidic sample from a patient, prevent or reduce spillage of the fluidic sample, reduce contamination of a fluidic sample, and/or prevent or reduce air from entering a fluidic sample or device compared to certain existing fluid collection devices.Type: GrantFiled: April 24, 2017Date of Patent: November 10, 2020Assignee: OPKO Diagnostics, LLCInventors: Jason Taylor, Hardeep Singh, Matthew Dirckx
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Patent number: 10684201Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.Type: GrantFiled: February 27, 2017Date of Patent: June 16, 2020Assignee: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Vincent Linder, Jason Taylor
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Publication number: 20190336968Abstract: Fluidic devices and methods are provided.Type: ApplicationFiled: March 18, 2019Publication date: November 7, 2019Applicant: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Jason Taylor, Vincent Linder
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Patent number: 10279345Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may include an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In certain embodiments, the detection channel may be used to provide feedback on the extent of incubation and/or mixing. Based on the feedback, one or more component of the fluidic system may be regulated to allow the requisite degree of mixing and/or incubation to be achieved.Type: GrantFiled: December 11, 2015Date of Patent: May 7, 2019Assignee: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Jason Taylor, Vincent Linder
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Publication number: 20170238857Abstract: Articles and methods for collecting and/or facilitating transfer of fluids are generally provided. In some embodiments, an article comprises a fluid collection region for introducing a fluid, such as a sample (e.g., blood sample) or a reagent, into a fluidic system. The articles and methods described herein may be useful for facilitating the filling of relatively small channels with a fluid, such as channels of a microfluidic device. The articles and methods may, for example, interface with a patient sample (e.g., a droplet of blood), or with a macroscopic fluid source such as a pipette or syringe. In certain embodiments, articles and methods described herein may increase the ease of collecting a fluidic sample from a patient, prevent or reduce spillage of the fluidic sample, reduce contamination of a fluidic sample, and/or prevent or reduce air from entering a fluidic sample or device compared to certain existing fluid collection devices.Type: ApplicationFiled: April 24, 2017Publication date: August 24, 2017Applicant: OPKO Diagnostics, LLCInventors: JASON TAYLOR, Hardeep Singh, Matthew Dirckx
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Publication number: 20170167958Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.Type: ApplicationFiled: February 27, 2017Publication date: June 15, 2017Applicant: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Vincent Linder, Jason Taylor
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Publication number: 20170168077Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may comprise an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In some embodiments, fluidic devices for performing a vitamin D assay are provided.Type: ApplicationFiled: December 8, 2016Publication date: June 15, 2017Applicant: OPKO Diagnostics, LLCInventors: DOUGLAS M. HADDAD, Gary J. Fagan, Yi Dong, Matthew Dirckx, Vincent Linder
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Patent number: 9588027Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active to components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.Type: GrantFiled: February 7, 2014Date of Patent: March 7, 2017Assignee: UPKO Diagnostics, LLCInventors: Matthew Dirckx, Vincent Linder, Jason Taylor
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Publication number: 20160207042Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may comprise an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In certain embodiments, the detection channel may be used to provide feedback on the extent of incubation and/or mixing. Based on the feedback, one or more component of the fluidic system may be regulated to allow the requisite degree of mixing and/or incubation to be achieved.Type: ApplicationFiled: December 11, 2015Publication date: July 21, 2016Applicant: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Jason Taylor, Vincent Linder
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Patent number: 9255866Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.Type: GrantFiled: July 30, 2014Date of Patent: February 9, 2016Assignee: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Vincent Linder, Jason Taylor
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Publication number: 20140342350Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.Type: ApplicationFiled: July 30, 2014Publication date: November 20, 2014Applicant: OPKO Diagnostics, LLCInventors: Matthew Dirckx, Vincent Linder, Jason Taylor
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Patent number: D804682Type: GrantFiled: August 10, 2015Date of Patent: December 5, 2017Assignee: OPKO Diagnostics, LLCInventors: Jason Taylor, Matthew Dirckx, David Steinmiller, Vincent Linder
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Patent number: D817511Type: GrantFiled: June 30, 2017Date of Patent: May 8, 2018Assignee: OPKO Diagnostics, LLCInventors: Jason Taylor, Matthew Dirckx, David Steinmiller, Vincent Linder