Abstract: The present disclosure provides a method of making a systematic single point mutation in a target nucleic acid and a method of generating a mutational library comprising target nucleic acids with single point mutations. The mutational library comprises target nucleic acids with single point mutations distributed evenly throughout the target nucleic acid.

Abstract: The present disclosure provides a method of making a systematic single point mutation in a target nucleic acid and a method of generating a mutational library comprising target nucleic acids with single point mutations. The mutational library comprises target nucleic acids with single point mutations distributed evenly throughout the target nucleic acid.

Abstract: The present invention relates to an orthotic device wherein the patient's feet are maintained at a desired angle while allowing the patient to move in an otherwise normal manner and preventing blister formation. The orthotic device generally comprises an orthotic splint assembly, two ankle foot orthosis and two custom molded inserts secured to the ankle foot orthosis.

Abstract: The present invention relates to an orthotic device wherein the patient's feet are maintained at a desired angle while allowing the patient to move in an otherwise normal manner and preventing blister formation. The orthotic device generally comprises an orthotic splint assembly, two ankle foot orthosis and two custom molded inserts secured to the ankle foot orthosis.

Abstract: A feedthrough terminal assembly for an active implantable medical device utilizes an insert to establish a reliable electrical connection between capacitor electrode plates, via inner surface metallization of a capacitor aperture, and an associated terminal pin 10, which passes at least partially therethrough. The inserts are preferably resiliently flexible, such as a spring, to establish this connection. The insert also serves to establish a mechanical connection between the capacitor and the terminal pin.

Abstract: A feedthrough terminal assembly for an active implantable medical device utilizes an insert to establish a reliable electrical connection between capacitor electrode plates, via inner surface metallization of a capacitor aperture, and an associated terminal pin 10, which passes at least partially therethrough. The inserts are preferably resiliently flexible, such as a spring, to establish this connection. The insert also serves to establish a mechanical connection between the capacitor and the terminal pin.

Abstract: A feedthrough terminal assembly for an active implantable medical device utilizes to establish a reliable electrical connection between capacitor electrode plates, via inner surface metallization of a capacitor aperture, and an associated terminal pin 10, which passes at least partially therethrough. The inserts are preferably resiliently flexible, such as a spring, to establish this connection. The insert also serves to establish a mechanical connection between the capacitor and the terminal pin.

Abstract: A feedthrough terminal assembly for an active implantable medical device utilizes to establish a reliable electrical connection between capacitor electrode plates, via inner surface metallization of a capacitor aperture, and an associated terminal pin 10, which passes at least partially therethrough. The inserts are preferably resiliently flexible, such as a spring, to establish this connection. The insert also serves to establish a mechanical connection between the capacitor and the terminal pin.

Abstract: A feedthrough capacitor filter assembly includes a capacitor having first and second sets of conductive electrode plates embedded within an insulative or dielectric body, and a leak detection vent for facilitated hermetic seal testing prior to use. At least one feedthrough terminal pin extends through the capacitor in conductive relative with the first set of electrode plates, and an outer ferrule is mounted about the capacitor in conductive relation with the second set of electrode plates. A hermetic seal is seated within the ferrule at one side of the capacitor to prevent leakage of fluid through the filter assembly. The hermetic seal is spaced from a face of the capacitor to form a gap therebetween.

Abstract: A feedthrough capacitor filter assembly includes a capacitor having first and second sets of conductive electrode plates embedded within an insulative or dielectric body, and a leak detection vent for facilitated hermetic seal testing prior to use. At least one feedthrough terminal pin extends through the capacitor in conductive relative with the first set of electrode plates, and an outer ferrule is mounted about the capacitor in conductive relation with the second set of electrode plates. A hermetic seal is seated within the ferrule at one side of the capacitor to prevent leakage of fluid through the filter assembly. The hermetic seal is spaced from a face of the capacitor to form a gap therebetween.