Patents by Inventor Matthew Edward Cockman

Matthew Edward Cockman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay for histidinyl hydroxylase activity
    Patent number: 9422589
    Abstract: The present invention relates to assays for monitoring activity of Mina53 and NO66 activities, in particular, to assays for identifying modulators of Mina53 and NO66 activities. The invention also relates to assays to monitor the histidinyl hydroxylase activity of Mina53 and NO66 on their substrates, the human ribosomal protein Rpl27a and Rpl8 respectively. The invention also enables the introduction of S-3-hydroxyhistidinyl residues into peptides and proteins.
    Type: Grant
    Filed: July 25, 2012
    Date of Patent: August 23, 2016
    Assignee: Isis Innovation Limited
    Inventors: Christopher Joseph Schofield, Wei Ge, Matthew Edward Cockman, Peter John Ratcliffe, Mathew Louis Coleman
  • Method for assaying OGFOD1 activity
    Patent number: 9228224
    Abstract: The present invention relates to assays for monitoring activity of OGFOD1 activity, in particular, to assays for identifying modulators of OGFOD1 activity. The invention also relates to assays to monitor the prolyl hydroxylase activity of OGFOD1 on its substrate, the human ribosomal protein RPS23. The invention also enables the introduction of 3-hydroxyprolyl residues into peptides and proteins.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: January 5, 2016
    Assignee: ISIS INNOVATION LIMITED
    Inventors: Christopher Joseph Schofield, Alexander Wolf, Wei Ge, Armin Thalhammer, Christoph Loenarz, Peter John Ratcliffe, Matthew Edward Cockman
  • ASSAY FOR HISTIDINYL HYDROXYLASE ACTIVITY
    Publication number: 20140248636
    Abstract: The present invention relates to assays for monitoring activity of Mina53 and NO66 activities, in particular, to assays for identifying modulators of Mina53 and NO66 activities. The invention also relates to assays to monitor the histidinyl hydroxylase activity of Mina53 and NO66 on their substrates, the human ribosomal protein Rpl27a and Rpl8 respectively. The invention also enables the introduction of S-3-hydroxyhistidinyl residues into peptides and proteins.
    Type: Application
    Filed: July 25, 2012
    Publication date: September 4, 2014
    Applicant: Isis Innovation Limited
    Inventors: Christopher Joseph Schofield, Wei Ge, Matthew Edward Cockman, Peter John Ratcliffe, Mathew Louis Coleman
  • METHOD FOR ASSAYING OGFOD1 ACTIVITY
    Publication number: 20140051106
    Abstract: The present invention relates to assays for monitoring activity of OGFOD1 activity, in particular, to assays for identifying modulators of OGFOD1 activity. The invention also relates to assays to monitor the prolyl hydroxylase activity of OGFOD1 on its substrate, the human ribosomal protein RPS23. The invention also enables the introduction of 3-hydroxyprolyl residues into peptides and proteins.
    Type: Application
    Filed: February 10, 2012
    Publication date: February 20, 2014
    Applicant: Isis Innovation Limited
    Inventors: Christopher Joseph Schofield, Alexander Wolf, Wei Ge, Armin Thalhammer, Christoph Loenarz, Peter John Ratcliffe, Matthew Edward Cockman
  • Assays for identifying modulators of the hydroxylation of ankyrin repeat proteins by 2-oxoglutarate dependent oxygenase and methods of using the same
    Patent number: 7638295
    Abstract: A method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity, the method comprising contacting a 2-oxoglutarate dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof, in conditions under which the substrate is hydroxylated in the absence of the test agent; and determining hydroxylation of the substrate.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: December 29, 2009
    Assignee: Isis Innovation Limited
    Inventors: Christopher Joseph Schofield, Kirsty Sarah Hewitson, Michael Arnold McDonough, Peter John Ratcliffe, Norma Masson, Matthew Edward Cockman
  • Assays
    Publication number: 20080227848
    Abstract: A method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity, the method comprising contacting a 2-oxoglutarate dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof, in conditions under which the substrate is hydroxylated in the absence of the test agent; and determining hydroxylation of the substrate.
    Type: Application
    Filed: March 24, 2005
    Publication date: September 18, 2008
    Applicant: Isis Innovation Limited
    Inventors: Christopher Joseph Schofield, Kirsty Sarah Hewitson, Michael Arnold McDonough, Peter John Ratcliffe, Norma Masson, Matthew Edward Cockman