Abstract: Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.

Abstract: A foreign particulate removal assembly for a laundry appliance includes a cabinet and a drum that is disposed within the cabinet. The drum includes a humidity sensor. The foreign particulate removal assembly further includes a fluid emitting feature that is operably coupled to a fluid housing proximate the drum. The fluid emitting feature is configured to selectively dispense fluid into the drum. A controller is communicatively coupled with the fluid emitting feature. The controller is configured to activate the fluid emitting feature when the humidity sensor detects a predetermined wetness of clothing items disposed within the drum.

Abstract: Presented herein are technologies and methods for improved production of AAV vectors.

Abstract: A method to detect an operator of an automobile vehicle includes: identifying if an emergency situation is occurring in an automobile vehicle; determining if a communication device is currently connected or was previously connected in the automobile vehicle; identifying a most recently connected operator of the communication device; and sending a signal identifying the emergency situation is occurring to the most recently connected operator of the communication device.

Abstract: The present disclosure is directed to an energy management system that allows leveraging DC energy at user premises. The system allows for use of local or remote DC energy generated by photovoltaic modules or a battery pack. The system comprises a premises electricity network interface arranged to deliver and draw energy to and from a premises electricity network; a premises energy measurement module arranged to measure the amount of energy required by the premises electricity network; a DC energy input arranged to receive energy from one or more DC energy sources; and an energy analytics module arranged to receive data from the energy measurement module and, based on the received data, calculate an amount of energy to be delivered to the premises electricity network via the premises electricity network interface.

Abstract: A vitrector that includes an adjustable illumination aperture is described. The vitrector may include a probe and a light sleeve assembly extending along and substantially surrounding the probe. The light sleeve assembly may include a plurality of optical fibers. At least a portion of the optical fibers are operable to provide illumination so as to define an illumination aperture about the vitrectomy probe. A portion of the optical fibers may be encapsulated. The light sleeve assembly may be adjustable along a length of the probe, providing adjustment of the illumination aperture to increase or decrease an area of illumination provided thereby.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for classifying a patient. In one aspect, a method comprises: receiving multi-modal data characterizing a patient, wherein the multi-modal data comprises a respective feature representation for each of a plurality of modalities; processing the multi-modal data characterizing the patient using an encoder neural network to generate an embedding of the multi-modal data characterizing the patient; determining a respective classification score for each patient category in a set of patient categories based on the embedding of the multi-modal data characterizing the patient; and classifying the patient as being included in a corresponding patient category from the set of patient categories based on the classification scores.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating a clinical recommendation for medical treatment of a patient.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for generating multi-modal data archetypes. In one aspect, a method comprises obtaining a plurality of training examples, wherein each training example corresponds to a respective patient and includes multi-modal data, having a plurality of feature dimensions, that characterizes the patient; jointly training an encoder neural network and a decoder neural network on the plurality of training examples; and generating a plurality of multi-modal data archetypes that each correspond to a respective dimension of a latent space, comprising, for each multi-modal data archetype: processing a predefined embedding that represents the corresponding dimension of the latent space using the decoder neural network to generate multi-modal data, having the plurality of feature dimensions, that defines the multi-modal data archetype.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for jointly training an encoder neural network and a decoder neural network. In one aspect, a method comprises: updating current values of a set of encoder parameters and current values of a set of decoder parameters using gradients of a reconstruction loss function that measures an error in a reconstruction of multi-modal data from a training example, wherein: the reconstruction loss function comprises a plurality of scaling factors that each scale a respective term in the reconstruction loss function that measures an error in the reconstruction of a corresponding proper subset of feature dimensions of the multi-modal data from the training example.

Abstract: An electrical connector system includes a receptacle connector assembly and a header connector assembly mated with the receptacle connector assembly. The receptacle connector assembly includes a receptacle connector housing holding receptacle contacts in a plurality of rows. The header connector includes a header connector housing holding header contacts in a plurality of rows. The contacts are laterally offset and longitudinally staggered in the rows to provide spacing between the contacts.

Abstract: Systems and methods include a process for generating negotiation targets and estimates for new PCS purchase agreements. A process control system (PCS) benchmarking database is generated using a PCS benchmarking tool and historical data from past and ongoing PCS purchase agreements. The PCS benchmarking database is maintained during execution of purchase agreements using information from executed purchase agreements. A new PCS purchase agreement is compared to previous PCS purchase agreements using the PCS benchmarking tool and the PCS benchmarking database. Negotiation targets and estimates for the new PCS purchase agreement are generated using the PCS benchmarking tool based on the comparing.

Abstract: A crash detection system for a vehicle comprises first and second batteries and a computational system comprising a processor and a non-transitory computer-readable medium. First and second antennas are both in electronic communication with the computational system and powered by one of the batteries, with the antennas configured to independently wirelessly communicate with an external network. A microphone powered by one of the batteries and in electronic communication with the computational system. The microphone continuously receives sound waves in real time and transmits sound signals to the processor. The processor monitors properties of the sound waves within the sound signals, compares the properties to thresholds stored in the non-transitory computer-readable medium, determines if the vehicle has been involved in a collision if at least one of the properties crosses the respective threshold, and communicates with the external network to report the collision with one of the antennas.

Abstract: Control systems and feedback assemblies for hydraulic axial displacement machines, such as pumps and motors. The control systems and feedback assemblies can have enhanced adjustability. An angle sensor for sensing the angular position of a pivot arm can have a housing, and the housing can be angularly adjustable about the pivot axis relative to the pivot arm.

Abstract: A ducted fan assembly includes a duct having an inlet, an inner surface, an expanding diffuser and an outlet. A fan disposed within the duct between the inlet and the expanding diffuser is configured to rotate about a fan axis to generate airflow. An active flow control system includes a plurality of injection zones circumferentially distributed about the inner surface. The expanding diffuser has a diffuser angle configured to create flow separation when the airflow is uninfluenced by the active flow control system such that the airflow has a thrust vector with a first direction that is substantially parallel to the fan axis. Injection of pressurized air from one of the injection zones asymmetrically reduces the flow separation between the airflow and the expanding diffuser downstream of that injection zone such that the thrust vector of the airflow has a second direction that is not parallel to the first direction.

Abstract: A computer-implemented method for completing queries propagated across a plurality of datasources that may include receiving a search query comprising a search string via an application user interface. Identity information regarding an end user associated with the search query may also be received. At least one role of the end user may be automatically determined and authorization metadata corresponding to the at least one role may be automatically appended to the search query. A plurality of adapters corresponding to the datasources may be invoked and the appended search query may be passed to the adapters. The appended search query may be translated by the adapters into a plurality of translated search queries according to the syntax and format configurations of the datasources. The translated search queries may be automatically submitted to the corresponding datasources. Responsive results may be automatically received and presented at an end user computing device.

Abstract: A crash detection system for a vehicle comprises first and second batteries and a computational system comprising a processor and a non-transitory computer-readable medium. First and second antennas are both in electronic communication with the computational system and powered by one of the batteries, with the antennas configured to independently wirelessly communicate with an external network. A microphone powered by one of the batteries and in electronic communication with the computational system. The microphone continuously receives sound waves in real time and transmits sound signals to the processor. The processor monitors properties of the sound waves within the sound signals, compares the properties to thresholds stored in the non-transitory computer-readable medium, determines if the vehicle has been involved in a collision if at least one of the properties crosses the respective threshold, and communicates with the external network to report the collision with one of the antennas.

Abstract: Some examples relate generally to managing and storing data, and more specifically to the real-time detection of ransomware, system (or insider) threats, or the misappropriation of credentials by using file system audit events.

Abstract: A laundry appliance includes a cabinet that has a user interface. A drum is disposed within the cabinet and includes baffles. A blower directs process air through an airflow path that includes the drum. A lint filter is disposed within the airflow path and between the drum and the blower. A foreign particulate collector is disposed within the drum and is configured to collect foreign particulates within the drum. A controller is operably coupled to a motor for rotating the drum and the blower. The user interface and the controller cooperate to operate the drum and the blower for capturing foreign particulates at least within the foreign particulate collector.

Abstract: A method to detect an operator of an automobile vehicle includes: identifying if an emergency situation is occurring in an automobile vehicle; determining if a communication device is currently connected or was previously connected in the automobile vehicle; identifying a most recently connected operator of the communication device; and sending a signal identifying the emergency situation is occurring to the most recently connected operator of the communication device.