Abstract: The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH)2, —P(O)(OH)(O?M+), —P(O)(O?M+)2 and —P(O)(O?)2M2+; M+ at each occurrence is a pharmaceutically acceptable monovalent cation; and M2+ is a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Abstract: Generating shared workspaces for enabling communications between users of different organizations and facilitating discovery of users associated with different organizations is described. A first user can generate a shared workspace and associate one or more other organizations therewith. The first user can designate first criteria associated with joining the shared workspace. The communication platform can receive a request from a second user to join the shared workspace. Based on a determination that the second user satisfies the first criteria, the communication platform can enable the second user access to the shared workspace. In some examples, an administrator associated with an organization of the second user can establish second criteria for users of the organization to join the shared workspace. In such examples, the communication platform can enable the second user access to the shared workspace based on a determination that the second user also satisfies the second criteria.

Abstract: An attachable adherence monitor that may be attached to different types of medicant dispensers is disclosed. The adherence monitor has a sensor body including sensing electronics that are triggered to indicate the activation of a medicant dispenser and assign a timestamp to the activation. The sensor body includes a storage device storing data indicating the activation of the medicant dispenser. The sensor body includes a connector conduit. A number of attachment modules are provided. Each of the attachment modules includes a connector that allows attachment to the sensor body via the connector conduit. A first attachment module includes a first attachment mechanism for attaching the sensor body to a first medicant dispenser. A second attachment module includes a different second attachment mechanism for attaching the sensor body to a second different medicant dispenser.

Abstract: A composition includes specific amounts of a copolycarbonate and a roughening agent. The copolycarbonate contains first carbonate units derived from a first bisphenol monomer such that a homopolycarbonate of the first bisphenol monomer has a glass transition temperature less than 155° C., and second carbonate units derived from a second bisphenol monomer such that a homopolycarbonate of the second bisphenol monomer has a glass transition temperature of 155° C. or higher. The roughening agent includes a particulate crosslinked polymethylsilsesquioxane having a median equivalent spherical diameter greater than 5 micrometers and less than or equal to 10 micrometers.

Abstract: A keyless puck lock apparatus with wireless communications and power interfaces. Embodiments of the present disclosure provide a keyless puck lock system enabling a low cost and high security solution that is difficult to tamper with and defeat. In the preferred embodiment of the present invention, the system uses a keyless puck lock assembly that includes a hasp assembly and a keyless lock mechanism that does not require any physical mechanical keys so that it does not have a mechanical cylinder inserted therein to lock or unlock the puck lock. Accordingly, the keyless puck lock system in accordance with one or more embodiments of the present invention does not have a physical keyway which is a security attack point that is included in conventional hockey puck-type locks.

Abstract: A fan assembly includes an internal housing having an outer internal housing, and an inner internal housing partially disposed within the outer internal housing. The inner internal housing defines an internal cavity, and has a curved exterior surface. Stator blades extend between the inner internal housing and the outer internal housing.

Abstract: A composition includes specific amounts of a copolycarbonate and a roughening agent. The copolycarbonate contains first carbonate units derived from a first bisphenol monomer such that a homopolycarbonate of the first bisphenol monomer has a glass transition temperature less than 155° C., and second carbonate units derived from a second bisphenol monomer such that a homopolycarbonate of the second bisphenol monomer has a glass transition temperature of 155° C. or higher. The roughening agent includes a particulate crosslinked polymethylsilsesquioxane having a median equivalent spherical diameter greater than 5 micrometers and less than or equal to 10 micrometers.

Abstract: A boat used in a chemical vapor deposition (CVD) furnace is configured to hold one or more complex three-dimensional (3D) structures when performing a coating. A platform wafer is placed horizontally in the boat to support the complex 3D structures and a mount is positioned to secure the complex 3D structures on the platform wafer during the CVD process. One or more “witness” wafers may also be placed in the boat for analyzing the thin-film coating. The platform wafer may be positioned between or bracketed by the vertical wafers. Parts with coatings manufactured using LPCVD are further disclosed.

Abstract: A smart sensor early warning notification system. Certain aspects of the present disclosure provide for a smart sensor early warning notification system comprising a smart sensor coupled to a door and configured to detect one or more unauthorized access events, including sawing, blunt force and other atypical vibrations to the door. A smart sensor may be communicably engaged with a local alarm to communicate sensor data received at the smart sensor. The local alarm may be configured to process the sensor data received from the smart sensor and trigger an alarm event and/or notification or pre-event detection alert in response to the sensor data. A door controller may be configured to send different pulses or messages to indicate the type of alarm event to an alarm management server and/or access control servers via public/private cloud.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a prediction of an audio signal. One of the methods includes receiving a request to generate an audio signal conditioned on an input; processing the input using an embedding neural network to map the input to one or more embedding tokens; generating a semantic representation of the audio signal; generating, using one or more generative neural networks and conditioned on at least the semantic representation and the embedding tokens, an acoustic representation of the audio signal; and processing at least the acoustic representation using a decoder neural network to generate the prediction of the audio signal.

Abstract: An integrated electronic locking system and electronic locking device configured to enable electronic access control of an integrated electronic locking device via multiple electronic access modalities across multiple user types/roles. An object of the present disclosure is an integrated electronic locking system configured to enable a system administrator to configure different access control parameters for two or more different access control modalities/types across two or more different users and/or use cases. In accordance with certain embodiments, an integrated electronic locking system comprises an integrated electronic locking device communicably engaged with a remote server over a wireless or wireline communications interface to enable one or more operations of an integrated electronic access control method.

Abstract: Methods, computer program products, and/or systems are provided that perform the following operations: determining a pacing requirement for host requests based on one or more thresholds; setting a pacing delay level based on the one or more thresholds in response to the determination of the pacing requirement; and implementing a memory request flow for a host request based on the pacing requirement and the pacing delay level.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for generating a prediction of an audio signal. One of the methods includes receiving a request to generate an audio signal conditioned on an input; processing the input using an embedding neural network to map the input to one or more embedding tokens; generating a semantic representation of the audio signal; generating, using one or more generative neural networks and conditioned on at least the semantic representation and the embedding tokens, an acoustic representation of the audio signal; and processing at least the acoustic representation using a decoder neural network to generate the prediction of the audio signal.

Abstract: The present invention provides, in part, compounds of Formula I: or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.

Abstract: A polycarbonate-polysiloxane includes specific amounts of first carbonate units having the structure wherein R1 is a C6-C16 divalent aromatic group, second carbonate units having the structure wherein R2 is a C17-C40 divalent aromatic group having the structure wherein Rf, Rg, Rh, Ri, Rj, Rk, Xb, j, m, n, x, and y are defined herein. The polycarbonate-polysiloxane is useful for forming thin extruded films, which in turn are useful for fabricating electrostatic film capacitors.

Abstract: The present disclosure generally relates to methods that utilize cell-free DNA from a liquid biopsy of an individual to track DNA from both the tumor and the chimeric antigen receptor (CAR) T-cells. The present disclosure further relates to methods of predicting individuals' response to therapy, e.g., CAR T-cell therapies. Additionally, the present disclosure relates to methods of treating individuals with cancer, such as lymphoma.

Abstract: A smart sensor early warning notification system. Certain aspects of the present disclosure provide for a smart sensor early warning notification system comprising a smart sensor coupled to a door and configured to detect one or more unauthorized access events, including sawing, blunt force and other atypical vibrations to the door. A smart sensor may be communicably engaged with a local alarm to communicate sensor data received at the smart sensor. The local alarm may be configured to process the sensor data received from the smart sensor and trigger an alarm event and/or notification or pre-event detection alert in response to the sensor data. A door controller may be configured to send different pulses or messages to indicate the type of alarm event to an alarm management server and/or access control servers via public/private cloud.

Abstract: A subassembly for a shaving razor cartridge with a base having a front wall with a top surface and a rear wall with a top surface. At least one blade is mounted to the base between the front wall and the rear wall. The at least one blade has a cutting edge positioned at least 0.5 mm below a plane tangent to the top surface of the front wall and the top surface of the rear wall.

Abstract: A subassembly for a shaving razor cartridge with a base having a front wall with a top surface and a rear wall with a top surface. At least one blade is mounted to the base between the front wall and the rear wall. The at least one blade has a cutting edge positioned at least 0.5 mm above a plane tangent to the top surface of the front wall and the top surface of the rear wall.