Abstract: The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their uses in medicine. In particular, the present invention provides an adenoviral vector comprising the genome of an adenovirus other than AdHu5 and AdY25, wherein the genome of the adenovirus has been modified such that the vector lacks the native E4 locus of the adenovirus and comprises heterologous E4Orfl, E4Orf2 and E4Orf3 coding regions from AdY25.

Abstract: Provided is a pumping system that includes a parallel dual chamber pumping mechanism and an attachable disposable cassette. The disposable cassette may include a multi-laminate membrane, which facilitates efficient, accurate and uniform delivery of fluids. The membrane can be held in intimate contact with the pumping fingers of the pumping mechanism by electrostatic or magnetic attraction, thereby allowing the pump to pull a vacuum without the need for a preloaded elastomeric pumping segment.

Abstract: Described is a large volume parenteral (LVP) infusion device system including a cassette and a pump. The system can include means for sensing pressure in a pump having a symmetric or matched, parallel dual chamber pumping mechanism and an attached cassette. The system can include a cassette having dual pumping chambers and a distal fitment, the distal fitment having an outlet port configured for attachment to tubing for infusion administration and being disposed on a distal end of the cassette, the distal fitment further including opposing cutouts. The system can also an air in line sensor, the AIL sensor configured to bracket the distal fitment at the position of the cutout when the cassette is loaded on the pump. The cassette can be mechanically coupled to the pump. The cassette can include a user actionable flow stop. The system can be configured for cassette misload protection.

Abstract: Provided is a pumping system that includes a parallel dual chamber pumping mechanism and an attachable disposable cassette. The disposable cassette may include a multi-laminate membrane, which facilitates efficient, accurate and uniform delivery of fluids. The membrane can be held in intimate contact with the pumping fingers of the pumping mechanism by electrostatic or magnetic attraction, thereby allowing the pump to pull a vacuum without the need for a preloaded elastomeric pumping segment.

Abstract: Provided is a pumping system that includes a parallel dual chamber pumping mechanism and an attachable disposable cassette. The disposable cassette includes a multi-laminate membrane which facilitates efficient, accurate and uniform delivery of fluids. The multi-laminate membrane is held in intimate contact with the pumping fingers of the pumping mechanism by electrostatic or magnetic attraction, thereby allowing the pump to pull a vacuum without the need for a preloaded elastomeric pumping segment.

Abstract: Provided is a pumping system that includes a parallel dual chamber pumping mechanism and an attachable disposable cassette. The disposable cassette includes a multi-laminate membrane which facilitates efficient, accurate and uniform delivery of fluids. The multi-laminate membrane is held in intimate contact with the pumping fingers of the pumping mechanism by electrostatic or magnetic attraction, thereby allowing the pump to pull a vacuum without the need for a preloaded elastomeric pumping segment.

Abstract: Provided is a pumping system that includes a parallel dual chamber pumping mechanism and an attachable disposable cassette. The disposable cassette includes a multi-laminate membrane which facilitates efficient, accurate and uniform delivery of fluids. The multi-laminate membrane is held in intimate contact with the pumping fingers of the pumping mechanism by electrostatic or magnetic attraction, thereby allowing the pump to pull a vacuum without the need for a preloaded elastomeric pumping segment.

Abstract: A syringe plunger driver system capable of capturing syringes of widely varying sizes comprises a pair of asymmetric plunger retainer arms pivotally mounted to a plunger driver. The system includes a low profile driver having a length that exceeds its width so that it may be mounted adjacent control modules and other operational modules. The arms are biased toward each other and one arm is longer than the other with a notch on an inside edge to receive the tip of the shorter arm when capturing small syringe flanges. A rotation knob mounted to the front surface of the low profile driver forces the arms apart when rotated to a first rotation position. A force sensor is mounted in the driver to detect occlusions in the fluid line. A processor monitors the force sensed by the force sensor and provides an alarm if the force exceeds a threshold.

Abstract: A syringe plunger driver system capable of capturing syringes of widely varying sizes comprises a pair of asymmetric plunger retainer arms pivotally mounted to a plunger driver. The system includes a low profile driver having a length that exceeds its width so that it may be mounted adjacent control modules and other operational modules. The arms are biased toward each other and one arm is longer than the other with a notch on an inside edge to receive the tip of the shorter arm when capturing small syringe flanges. A rotation knob mounted to the front surface of the low profile driver forces the arms apart when rotated to a first rotation position. A force sensor is mounted in the driver to detect occlusions in the fluid line. A processor monitors the force sensed by the force sensor and provides an alarm if the force exceeds a threshold.

Abstract: Provided is a pumping system that includes a parallel dual chamber pumping mechanism and an attachable disposable cassette. The disposable cassette includes a multi-laminate membrane which facilitates efficient, accurate and uniform delivery of fluids. The multi-laminate membrane is held in intimate contact with the pumping fingers of the pumping mechanism by electrostatic or magnetic attraction, thereby allowing the pump to pull a vacuum without the need for a preloaded elastomeric pumping segment.

Abstract: A syringe plunger driver system capable of capturing syringes of widely varying sizes comprises a pair of asymmetric plunger retainer arms pivotally mounted to a plunger driver. The system includes a low profile driver having a length that exceeds its width so that it may be mounted adjacent control modules and other operational modules. The arms are biased toward each other and one arm is longer than the other with a notch on an inside edge to receive the tip of the shorter arm when capturing small syringe flanges. A rotation knob mounted to the front surface of the low profile driver forces the arms apart when rotated to a first rotation position. A force sensor is mounted in the driver to detect occlusions in the fluid line. A processor monitors the force sensed by the force sensor and provides an alarm if the force exceeds a threshold.

Abstract: An external adjustable ballast system for keeled sailboats comprising a weight that is designed for low hydrodynamic drag, mounted through a beam to a shaft running down the leading edge of the fin keel. Turning the shaft moves the weight to optimize hull trim, both fore/aft and athwartships, for a particular point of sail. If the weight and beam are shaped as a lifting body and mounted to the shaft such that it pivots as it rotates to optimize angle of attack, the dynamic balancing component can allow for a lighter weight. Ballast weight and beam can be raised or lowered to optimize performance for expected wind conditions. The leading edge of the fin keel is a rotatable non spherical shaft. When rotated, the shaft creates an asymmetric cross section which improves hydrodynamic efficiency of the keel.

Abstract: An external adjustable ballast system for keeled sailboats comprising a weight that is designed for low hydrodynamic drag, mounted through a beam to a shaft running down the leading edge of the fin keel. Turning the shaft moves the weight to optimize hull trim, both fore/aft and athwart ships, for a particular point of sail. If the weight and beam are shaped as a lifting body and mounted to the shaft such that it pivots as it rotates to optimize angle of attack, the dynamic balancing component can allow for a lighter weight. Ballast weight and beam can be raised or lowered to optimize performance for expected wind conditions. The leading edge of the fin keel is a rotatable non spherical shaft. When rotated, the shaft creates an asymmetric cross section which improves hydrodynamic efficiency of the keel.

Abstract: A syringe plunger driver system capable of capturing syringes of widely varying sizes comprises a pair of asymmetric plunger retainer arms pivotally mounted to a plunger driver. The system includes a low profile driver having a length that exceeds its width so that it may be mounted adjacent control modules and other operational modules. The arms are biased toward each other and one arm is longer than the other with a notch on an inside edge to receive the tip of the shorter arm when capturing small syringe flanges. A rotation knob mounted to the front surface of the low profile driver forces the arms apart when rotated to a first rotation position. A force sensor is mounted in the driver to detect occlusions in the fluid line. A processor monitors the force sensed by the force sensor and provides an alarm if the force exceeds a threshold.

Abstract: A syringe plunger driver system capable of capturing syringes of widely varying sizes comprises a pair of asymmetric plunger retainer arms pivotally mounted to a plunger driver. The system includes a low profile driver having a length that exceeds its width so that it may be mounted adjacent control modules and other operational modules. The arms are biased toward each other and one arm is longer than the other with a notch on an inside edge to receive the tip of the shorter arm when capturing small syringe flanges. A rotation knob mounted to the front surface of the low profile driver forces the arms apart when rotated to a first rotation position. A force sensor is mounted in the driver to detect occlusions in the fluid line. A processor monitors the force sensed by the force sensor and provides an alarm if the force exceeds a threshold.

Abstract: A fluid infusion pump includes a platen between an outer door and the pumping mechanism. The platen is located so that as the outer door of the pump is moved to the closed position, it moves the platen to position the fluid flow tube into occlusive contact with the pumping mechanism before the platen engages a flow stop formed integrally with the tube and releases the flow stop to permit fluid flow, thus avoiding a free flow condition. The door also includes a handle having a sear with a hook that engages the flow stop when the door is in the closed position. As the door is opened, the hook moves the flow stop to the occluded position before the platen is moved away from the tube thus preventing a free flow condition. The platen includes a flow stop release portion that is offset from the remainder of the platen that operatively engages a release tab on the flow stop to permit movement of the flow stop to the fluid flow configuration.

Abstract: A fluid infusion pump includes a platen between an outer door and the pumping mechanism. The platen is located so that as the outer door of the pump is moved to the closed position, it moves the platen to position the fluid flow tube into occlusive contact with the pumping mechanism before the platen engages a flow stop formed integrally with the tube and releases the flow stop to permit fluid flow, thus avoiding a free flow condition. The door also includes a handle having a sear with a hook that engages the flow stop when the door is in the closed position. As the door is opened, the hook moves the flow stop to the occluded position before the platen is moved away from the tube thus preventing a free flow condition. The platen includes a flow stop release portion that is offset from the remainder of the platen that operatively engages a release tab on the flow stop to permit movement of the flow stop to the fluid flow configuration.

Abstract: A flexible tube occluder has a body portion and a slider portion which act to occlude a tube to prevent unwanted flow of fluid to a patient. The body portion and slider portion are engaged such that slider portion can move relative to body portion. The body portion extends the full range of slider portion's motion and thus the occluder allows for stable occluding and open positions. The slider portion has a slot of varying size which is used to occlude the tube by pressing the tube within the surface of the slot and to allow free flow of fluid through the tube.

Abstract: An engineered pumping segment for facilitating efficient and accurate peristaltic pumping of fluids, providing regulation of fluid flow and providing an effective interface for sensing fluid line pressure in a peristaltic pump system. The engineered pumping segment includes an elastomeric membrane sandwiched between a rigid base and a rigid cover and a slider adapted to slidably mount about the base and cover. The membrane and base define a channel for fluid flow and the membrane, base and cover cooperate to facilitate peristaltic pumping of fluids through the engineered pumping segment and to provide a pressure sensing interface, and in combination with the slider, cooperate to regulate fluid flow.

Abstract: An air-in-line sensing apparatus for use with a parenteral fluid administration set to detect the passage of air through a fluid conduit. The apparatus comprises a first housing having a first arcuate section mounting a first transducer adjacent the first arcuate section and a second housing having a second arcuate section mounting a second transducer adjacent the second arcuate section. One housing is independently movable relative to the other housing so that when the movable housing is moved towards the other housing, the first and second arcuate sections capture a length of administration set tubing therebetween providing secure intimate contact therewith. A signal may be generated from one of such transducers, passed through the fluid conduit and received by the other transducer to detect whether the conduit is carrying air.