Patents by Inventor Matthew Hassler

Matthew Hassler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IONIC TAGS FOR SYNTHESIS OF OLIGORIBONUCLEOTIDES
    Publication number: 20190062355
    Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II): processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
    Type: Application
    Filed: March 19, 2018
    Publication date: February 28, 2019
    Inventors: Masad J. Damha, Matthew Hassler, Tak-Hang Chan, Mallikarjuna Reddy Nandyala, Robert Alexander Donga
  • TWO-TAILED SELF-DELIVERING SIRNA
    Publication number: 20190024082
    Abstract: Provided are compositions and methods comprising two-tailed siRNAs (tt-siRNAs) that exhibit unprecedented cellular uptake and silencing. Also provided are methods of treating neurological and other diseases with the two-tailed siRNAs of the invention.
    Type: Application
    Filed: June 22, 2018
    Publication date: January 24, 2019
    Inventors: Anastasia Khvorova, Julia Alterman, Matthew Hassler
  • Ionic tags for synthesis of oligoribonucleotides
    Patent number: 9920084
    Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
    Type: Grant
    Filed: August 23, 2012
    Date of Patent: March 20, 2018
    Assignees: The Royal Institution for the Advancement of Learning/McGill University, Hong Kong Polytechnic University
    Inventors: Masad J. Damha, Matthew Hassler, Tak-Hang Chan, Mallikarjuna Reddy Nandyala, Robert Alexander Donga
  • FULLY STABILIZED ASYMMETRIC SIRNA
    Publication number: 20170369882
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: August 30, 2017
    Publication date: December 28, 2017
    Inventors: Anastasia Khvorova, Neil Aronin, Matthew Hassler, Julia Alterman
  • BRANCHED OLIGONUCLEOTIDES
    Publication number: 20170312367
    Abstract: Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.
    Type: Application
    Filed: January 30, 2017
    Publication date: November 2, 2017
    Inventors: Anastasia Khvorova, Matthew Hassler, Julia Alterman
  • BIOACTIVE CONJUGATES FOR OLIGONUCLEOTIDE DELIVERY
    Publication number: 20170043024
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: August 12, 2016
    Publication date: February 16, 2017
    Inventors: Anastasia Khvorova, Mehran Nikan, Matthew Hassler, Maire Osborn, Reka Haraszti, Andrew Coles, Anton Turanov, Neil Aronin
  • FULLY STABILIZED ASYMMETRIC SIRNA
    Publication number: 20160319278
    Abstract: Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.
    Type: Application
    Filed: April 1, 2016
    Publication date: November 3, 2016
    Inventors: Anastasia Khvorova, Neil Aronin, Matthew Hassler, Julia Alterman
  • Ionic Tags for Synthesis of Oligoribonucleotides
    Publication number: 20140256926
    Abstract: The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.
    Type: Application
    Filed: August 23, 2012
    Publication date: September 11, 2014
    Applicants: Hong Kong Polytechnic University, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Masad J. Damha, Matthew Hassler, Tak-Hang Chan, Mallikarjuna Reddy Nandyala, Robert Alexander Donga