Patents by Inventor Matthew J. Brown
Matthew J. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240158760Abstract: Described are compositions, methods, systems, and kits related to related to synthetic phages with a customized host range. Customized host range of the synthetic phage is imparted on the synthetic phage by one or more recombinant tail-spike proteins. For example, a recombinant tail-spike protein may include a combination of the N-terminal region and the C-terminal region is engineered in a laboratory.Type: ApplicationFiled: November 10, 2023Publication date: May 16, 2024Applicant: Laboratory Corporation of America HoldingsInventors: Stephen Erickson, Jose S. Gil, Matthew J. Brown, John Paulson
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Publication number: 20240122276Abstract: Aspects herein are directed to an apparel item that promotes thermo-regulation through the use of engineered openings, venting, and/or stand-off structures. In exemplary aspects, 20-45% of the apparel item may comprise the engineered openings. Vents may be positioned on the apparel item in areas that experience high amounts of air flow to help channel air into the apparel item. The stand-off structures may be positioned on an inner-facing surface of the apparel item where they help to create a space between the apparel item and the wearer's body surface in which air can flow and help cool the wearer by promoting evaporative cooling.Type: ApplicationFiled: December 8, 2023Publication date: April 18, 2024Inventors: Collin Bailey, Kim D. Baschak, Olivia A. Echols, Stacey L. Hansen, Lucas Hartman, Rebecca P. Hurd, Adam Parkinson, Shannon K. Redell, David Sagan, Susan L. Sokolowski, Stuart B. Brown, Matthew J. Hancock
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Patent number: 11954022Abstract: Provided are a storage device, system, and method for throttling host writes in a host buffer to a storage device. The storage device is coupled to a host system having a host buffer that includes reads and writes to pages of the storage device. Garbage collection consolidates valid data from pages in the storage device to fewer pages. A determination is made as to whether a processing measurement at the storage device satisfies a threshold. A timer value is set to a positive value in response to determining that the processing measurement satisfies the threshold. The timer is started to run for the timer value. Writes from the host buffer are blocked while the timer is running. Writes remain in the host buffer while the timer is running. A write is accepted from the host buffer to process in response to expiration of the timer.Type: GrantFiled: March 2, 2022Date of Patent: April 9, 2024Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Matthew S. Reuter, Timothy J. Fisher, Aaron Daniel Fry, Jenny L. Brown, John Carrington Cates, Austin Eberle
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Patent number: 11952611Abstract: Disclosed herein are methods and systems for rapid detection of antibiotic resistance of a microorganism in a sample. A modified recombinant phage is also disclosed which comprises an indicator gene in the late gene region. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.Type: GrantFiled: July 3, 2018Date of Patent: April 9, 2024Assignee: Laboratory Corporation of America HoldingsInventors: Minh Mindy Bao Nguyen, Dwight L. Anderson, Jose S. Gil, Stephen E. Erickson, Matthew J. Brown
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Publication number: 20230365149Abstract: Systems and methods of using a common control scheme to autonomously control a vehicle during semi-autonomous and fully autonomous driving modes are provided. In particular, embodiments of the presently disclosed technology incorporate reference tracking for driving input and vehicle state into this common control scheme. In some embodiments, this common control scheme may be implemented using Model Predictive Control (“MPC”).Type: ApplicationFiled: May 12, 2023Publication date: November 16, 2023Inventors: Carrie G. BOBIER-TIU, Sarah M. KOEHLER, Matthew J. BROWN, Manuel AHUMADA
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Publication number: 20230347887Abstract: Systems and methods are provided for lane biasing, e.g., positioning a vehicle within a current lane of travel. Lane biasing can be dependent on learned driver behaviors or other factors that may impact lane biasing, e.g., weather conditions, traffic conditions, and so on (which may also be learned). Lane biasing may result in a vehicle traveling, e.g., off the center-line of a current lane of travel, and is distinguished from conventional lane keep assist systems that merely position a vehicle in the center of a current lane of travel by default.Type: ApplicationFiled: April 28, 2022Publication date: November 2, 2023Applicants: TOYOTA RESEARCH INSTITUTE, INC., TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: GABRIELLE M. FAVREAU, Carrie G. BOBIER-TIU, Sarah M. KOEHLER, Matthew J. BROWN, Guillermo PITA GIL
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Publication number: 20230347919Abstract: The disclosure generally describes a system and method for determining a preferred steering wheel rate in autonomous and semi-autonomous driving systems that includes measuring a torque applied to the steering wheel by a driver during an autonomous driving mode, measuring the steering wheel position, measuring the steering wheel rate of rotation, wherein the steering position and rate of rotation are measured at the time when the torque was applied to the steering wheel, determining a preferred steering wheel rate of rotation, and adjusting the steering wheel rate of rotation during an autonomous driving maneuver to include the preferred steering wheel rate.Type: ApplicationFiled: April 28, 2022Publication date: November 2, 2023Applicants: TOYOTA RESEARCH INSTITUTE, INC., TOYOTA JIDOSHA KABUSHIKI KAISHAInventors: MANUEL AHUMADA, Sarah M. Koehler, Matthew J. Brown
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Publication number: 20220349887Abstract: Disclosed herein are methods, compositions, kits, and systems for rapid multiplex detection of a microorganism of interest. Recombinant bacteriophages encoding capture moiety-indicator protein fusion products allow for the capture of indicator proteins on a surface. Cocktail compositions of recombinant bacteriophages can be used to detect potentially harmful bacteria. The specificity of recombinant bacteriophages for binding microorganisms allows targeted and highly specific detection of a microorganism of interest.Type: ApplicationFiled: April 29, 2022Publication date: November 3, 2022Inventors: Stephen E. Erickson, Jose S. Gil, Matthew J. Brown
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Publication number: 20220243181Abstract: Disclosed herein are methods and systems for rapid detection of microorganisms such as Listeria spp. in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Listeria-specific bacteriophage, allows detection of a specific microorganism, such as Listeria spp. and an indicator signal may be amplified to optimize assay sensitivity.Type: ApplicationFiled: February 4, 2022Publication date: August 4, 2022Inventors: Stephen Erickson, Jose S. Gil, Matthew J. Brown, Minh Mindy Bao Nguyen, Wendy Hahn
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Publication number: 20220214343Abstract: Disclosed herein are methods, compositions, kits, and systems for rapid detection of a microorganism of interest on a surface, including medical devices. Cocktail compositions of recombinant bacteriophages can be used to detect potentially harmful bacteria. The specificity of recombinant bacteriophages for binding microorganisms allows targeted and highly specific detection of a microorganism of interest.Type: ApplicationFiled: November 23, 2021Publication date: July 7, 2022Inventors: Stephen E. Erickson, Jose S. Gil, Matthew J. Brown, Minh MIndy Bao Nguyen
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Publication number: 20210341477Abstract: Disclosed are compositions, methods and systems for detecting MRSA, for example MRSA nasal colonization. In certain embodiments, the methods use bacteriophage-based amplification of the signal in detection of bacteria and other microorganisms to detect MRSA. The methods for detecting MRSA may include preparing an assay comprising a selective agent and a cocktail comprising at least two different types of recombinant bacteriophages, incubating the sample in the assay, capturing an indicator protein product, and detecting an indicator protein product produced by the recombinant bacteriophage, wherein positive detection of the indicator protein product indicates that MRSA is present in the sample.Type: ApplicationFiled: April 30, 2021Publication date: November 4, 2021Inventors: Matthew J. Brown, Minh Mindy Bao Nguyen, Stephen Erickson, Jose Gil
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Publication number: 20190010534Abstract: Disclosed herein are methods and systems for rapid detection of antibiotic resistance of a microorganism in a sample. A modified recombinant phage is also disclosed which comprises an indicator gene in the late gene region. The specificity of infectious agents allows a specific microorganism to be targeted, and an indicator signal may be amplified to optimize assay sensitivity.Type: ApplicationFiled: July 3, 2018Publication date: January 10, 2019Inventors: Minh Mindy Bao Nguyen, Dwight L. Anderson, Jose S. Gil, Stephen E. Erickson, Matthew J. Brown
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Publication number: 20140188675Abstract: A system for expense calculation, accrual, allocation, and reconciliation, including an expense calculation module configured to receive transaction data relating to a transaction and to apply at least one charge rule to the transaction data to calculate expense data detailing the expenses expected to be charged in association with the transaction; an accounting control module configured to receive the expense data as an input and to apply at least one accounting rule to the expense data to create enhanced data relating to the transaction; and an invoice reconciliation module configured to receive as inputs the expense data as well as invoice data related to the transaction, and to determine whether the invoice data matches the expense data for the transaction.Type: ApplicationFiled: December 31, 2013Publication date: July 3, 2014Applicant: Credit Suisse Securities (USA) LLCInventors: Matthew J. Brown, Michael Burke, Ted Piper, Bharat Malesha
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Patent number: 7293816Abstract: A structural rail system 10 for supporting an overhead console 12 in relation to a roof bow 13 within a vehicle. A pair of rail members 14, 16 are spaced apart and extend longitudinally. One or more brackets 18, 20, 22, 24 are oriented laterally in relation to the pair of rail members 14, 16. Accessories 26 are attached to the brackets 18, 20, 22, 24 and are housed within the console 12.Type: GrantFiled: April 20, 2005Date of Patent: November 13, 2007Assignee: International Automotive Components Group North America, Inc.Inventors: Jay Stone, Mark Niedzwiecki, John M. Tiesler, Matthew J. Brown
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Patent number: 5105521Abstract: A modular headliner includes an assist strap for mounting to the modular headliner to the vehicle body structure and includes an assist strap fastening means. The fastening means extends to engage a vehicle body adjacent an opening defined by a vehicle body structure. A mandrel may then be inserted between the fastening means to lock the fastening means to the vehicle body structure to thereby mount the assist strap and headliner to vehicle body structure.The assist strap may include a pivotally mounted handle having a preassembly position such that upon displacement of the handle, the mandrel is displaced to the locking position. Additionally a breakaway tab means may secure the handle to the assist strap base such that until sufficient force is applied to the handle to rupture the breakaway tab the handle will not be displaced. The tab is tuned to require that a sufficient force be sufficient to drive the mandrel to the locking position.Type: GrantFiled: August 10, 1990Date of Patent: April 21, 1992Assignee: United Technologies Automotive, Inc.Inventors: James D. Dowd, David M. Hilborn, Matthew J. Brown, Richard P. Bozyk
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Patent number: 4981322Abstract: An assist strap is installed by rotating an assist strap handle to drive a mandrel, in the base of the assist strap, into a projection in a service on which the assist strap is mounted. An apparatus for mounting an assist strap in a motor vehicle includes projecting fastening means extending from the base of the assist strap and a mandrel mounted to slide between a first position disengaged from the fastening means and a second position wherein the mandrel engages the fastening means to limit the movement of the fastening means thereby locking the fastening means to the vehicle body structure. A handle may be mounted to the base for pivotal movement such that applying a force to the handle drives the mandrel from the first position to the second position.Type: GrantFiled: June 10, 1988Date of Patent: January 1, 1991Assignee: United Technologies Corporation, Inc.Inventors: James D. Dowd, David M. Hilborn, Matthew J. Brown
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Patent number: 4981323Abstract: A modular headliner includes an assist strap for mounting to the modular headliner to the vehicle body structure and includes an assist strap fastening means. The fastening means extends to engage a vehicle body adjacent an opening defined by a vehicle body structure. A mandrel may then be inserted between the fastening means to lock the fastening means to the vehicle body structure to thereby mount the assist strap and headliner to vehicle body structure. The assist strap may include a pivotally mounted handle having a preassembly position such that upon displacement of the handle, the mandrel is displaced to the locking position. Additionally a breakaway tab means may secure the handle to the assist strap base such that until sufficient force is applied to the handle to rupture the breakaway tab the handle will not be displaced. The tab is tuned to require that a sufficient force be sufficient to drive the mandrel to the locking position.Type: GrantFiled: June 10, 1988Date of Patent: January 1, 1991Assignee: United Technologies Automotive, Inc.Inventors: James D. Dowd, David M. Hilborn, Matthew J. Brown, Richard P. Bozyk