Abstract: A system includes a plurality of thermostats corresponding to a plurality of HVAC systems that serve a plurality of spaces and a computing system communicable with the plurality of thermostats via a network. The computing system is configured to, for each space of the plurality of spaces, obtain a set of training data relating to thermal behavior of the space, identify a model of thermal behavior of the space based on the set of training data, perform a model predictive control process using the model of thermal behavior of the space to obtain a temperature setpoint for the space, and provide the temperature setpoint to the thermostat corresponding to the HVAC system serving the space. The plurality of thermostats are configured to control the plurality of HVAC systems in accordance with the temperature setpoints.

Abstract: A heating, ventilation, or air conditioning (HVAC) system for a building includes HVAC equipment configured to provide heating or cooling to one or more building spaces and one or more controllers. The one or more controllers include one or more processing circuits configured to generate energy targets for the one or more building spaces using a thermal capacitance of the one or more building spaces to which the heating or cooling is provided by the HVAC equipment, generate setpoints for the HVAC equipment using the energy targets for the one or more building spaces to which the heating or cooling is provided by the HVAC equipment, and operate the HVAC equipment using the setpoints to provide the heating or cooling to the one or more building spaces.

Abstract: An environmental control system of a building including a first building device operable to affect environmental conditions of a zone of the building by providing a first input to the zone. The system includes a second building device operable to independently affect a subset of the environmental conditions by providing a second input to the zone and further includes a controller including a processing circuit. The processing circuit is configured to perform an optimization to generate control decisions for the building devices. The optimization is performed subject to constraints for the environmental conditions and uses a predictive model that predicts an effect of the control decisions on the environmental conditions. The processing circuit is configured to operate the building devices in accordance with the control decisions.

Abstract: A controller for a building control system includes processors and memory storing instructions that, when executed by the processors, cause the processors to perform operations including identifying zones within a building, analyzing data associated with the zones, and generating zone groupings based on the data associated with the zones. Each of the zone groupings define zone groups and specify which of the zones are grouped together to form each of the zone groups. The operations also include identifying a particular zone grouping from zone groupings based on the data associated with zones and using the particular zone grouping to generate control signals to operate equipment of the building control system to provide heating or cooling to the zones.

Abstract: A controller for a building control system includes processors and memory storing instructions that, when executed by the processors, cause the processors to perform operations including identifying zones within a building, analyzing data associated with the zones, and generating zone groupings based on the data associated with the zones. Each of the zone groupings define zone groups and specify which of the zones are grouped together to form each of the zone groups. The operations also include identifying a particular zone grouping from zone groupings based on the data associated with zones and using the particular zone grouping to generate control signals to operate equipment of the building control system to provide heating or cooling to the zones.

Abstract: Systems and methods for modeling and controlling entities of a building system are provided. An exemplary method includes comparing an input indicating a new entity or connection between entities of a building system to a data model for the building system to determine whether the new entity or connection is represented in the data model, extending the data model to define the new entity or connection in response to determining that the new entity or connection is not represented in the data model, and using the data model with the new entity or connection in a control strategy to generate control decisions for the entities of the building system.

Abstract: A heating, ventilation, or air conditioning (HVAC) system for a building includes airside HVAC equipment configured to provide heating or cooling to one or more building spaces and one or more controllers. The one or more controllers are configured to generate airside energy targets for the one or more building spaces using a heat transfer model that defines a relationship between the airside energy targets, a temperature of the one or more building spaces, and a thermal capacitance of the one or more building spaces. The one or more controllers are configured to control the airside HVAC equipment in accordance with the airside energy targets.

Abstract: The present invention provides methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer. Methods of the invention further include means for evaluating gene expression profiles, including microarrays and quantitative polymerase chain reaction assays, as well as kits comprising reagents for practicing the methods of the invention.

Abstract: Methods for classifying and for evaluating the prognosis of a subject having breast cancer are provided. The methods include prediction of breast cancer subtype using a supervised algorithm trained to stratify subjects on the basis of breast cancer intrinsic subtype. The prediction model is based on the gene expression profile of the intrinsic genes listed in Table 1. This prediction model can be used to accurately predict the intrinsic subtype of a subject diagnosed with or suspected of having breast cancer. Further provided are compositions and methods for predicting outcome or response to therapy of a subject diagnosed with or suspected of having breast cancer. These methods are useful for guiding or determining treatment options for a subject afflicted with breast cancer.

Abstract: A thermostat for a building zone includes at least one of a model predictive controller and an equipment controller. The model predictive controller is configured to obtain a cost function that accounts for a cost of operating HVAC equipment during each of a plurality of time steps, use a predictive model to predict a temperature of the building zone during each of the plurality of time steps, and generate temperature setpoints for the building zone for each of the plurality of time steps by optimizing the cost function subject to a constraint on the predicted temperature. The equipment controller is configured to receive the temperature setpoints generated by the model predictive controller and drive the temperature of the building zone toward the temperature setpoints during each of the plurality of time steps by operating the HVAC equipment to provide heating or cooling to the building zone.

Abstract: A method for controlling equipment includes grouping a plurality of granular assets to form one or more general assets and generating models of the general assets based on the granular assets that form the general assets. Each model corresponds to a general asset and defines a relationship between resources produced by the general asset and resources consumed by the general asset. The method includes performing a first control process using the models of the general assets to determine a first allocation of resources among the general assets. The first allocation defines amounts of the resources to be consumed, produced, or stored by each of the general assets. The method includes operating the equipment to consume, produce, or store the resources in accordance with the first allocation.

Abstract: A thermostat for a building zone includes at least one of a model predictive controller and an equipment controller. The model predictive controller is configured to obtain a cost function that accounts for a cost of operating HVAC equipment during each of a plurality of time steps, use a predictive model to predict a temperature of the building zone during each of the plurality of time steps, and generate temperature setpoints for the building zone for each of the plurality of time steps by optimizing the cost function subject to a constraint on the predicted temperature. The equipment controller is configured to receive the temperature setpoints generated by the model predictive controller and drive the temperature of the building zone toward the temperature setpoints during each of the plurality of time steps by operating the HVAC equipment to provide heating or cooling to the building zone.

Abstract: A heating, ventilation, or air conditioning (HVAC) system for a building includes HVAC equipment configured to provide heating or cooling to one or more building spaces and one or more controllers. The one or more controllers include one or more processing circuits configured to generate energy targets for the one or more building spaces using a thermal capacitance of the one or more building spaces to which the heating or cooling is provided by the HVAC equipment, generate setpoints for the HVAC equipment using the energy targets for the one or more building spaces to which the heating or cooling is provided by the HVAC equipment, and operate the HVAC equipment using the setpoints to provide the heating or cooling to the one or more building spaces.

Abstract: A method for controlling production of one or more refined resources by an energy provider includes predicting a demand for the refined resources by one or more consumers of the refined resources as a function of an incentive offered by the energy provider. The method further includes performing an optimization of an objective function subject to a constraint based on the predicted demand for the refined resources to determine an amount of the refined resources for the energy provider to produce and a value of the incentive at multiple times within a time period. The method also includes providing setpoints for equipment of the energy provider that cause the equipment to produce the amount of the refined resources determined by performing the optimization.

Abstract: A controller for operating building equipment of a building including processors and non-transitory computer-readable media storing instructions that, when executed by the processors, cause the processors to perform operations including obtaining a first setpoint trajectory from a cloud computation system. The first setpoint trajectory includes setpoints for the building equipment or for a space of the building. The setpoints correspond to time steps of an optimization period. The operations include determining whether a connection between the controller and the cloud computation system is active or inactive at a time step of the optimization period and determining an active setpoint for the time step of the optimization period using either the first or second setpoint trajectory based on whether the connection between the controller and the cloud computation system is active or inactive at the time step. The operations include operating the building equipment based on the active setpoint.

Abstract: Methods disclosed herein concern cancer proteogenomics, which integrates genomics, transcriptomics and mass spectrometry (MS)-based proteomics to gain insights into cancer biology and treatment efficacy. To promote clinical utility of embodiments herein, proteogenomics approaches were developed for frozen core needle biopsies using tissue-sparing specimen processing with or without a microscaled proteomics workflow.

Abstract: An environmental control system for a building including building equipment operable to affect a variable state or condition of the building. The system includes a controller including a processing circuit. The processing circuit can obtain training data relating to operation of the building equipment and can perform a system identification process to identify parameters of a system model using the training data. The processing circuit can augment the system model with a disturbance model and estimate values of a historical heat disturbance in the training data based on the augmented system model. The processing circuit can train one or more heat disturbance models based on the training data and the estimated values. The processing circuit can predict a heat disturbance using the augmented system model along with the one or more heat disturbance models and can control the building equipment based on the predicted heat disturbance.

Abstract: A controller for maintaining occupant comfort in a space of a building. The controller includes processors and non-transitory computer-readable media storing instructions that, when executed by the processors, cause the processors to perform operations. The operations include obtaining building data and obtaining occupant comfort data. The operations include generating an occupant comfort model relating the building data to a level of occupant comfort within the space based on the building data and the occupant comfort data. The operations include generating time-varying comfort constraint for an environmental condition of the space using the occupant comfort model and include performing a cost optimization of a cost function of operating building equipment over a time duration to determine a setpoint for the building equipment. The operations include operating the building equipment based on the setpoint to affect the variable state or condition of the space.

Abstract: Embodiments of the disclosure concern determination of suitability of a particular type of therapy for ER+ cancers based on the presence of loss of members of double-strand break repair (such as MutL) and members of single-strand break repair. In particular, the loss of expression and/or mutation of CETN2, ERCC1, NEIL2, MLH1, and PMS2 is indicative of the particular ER+ cancer as being sensitive to one or more CDK-4/6 inhibitors. In specific cases, determination of loss of at least MutL renders the individual suitable for therapy with one or more CDK-4/6 inhibitors.

Abstract: A controller for operating building equipment of a building including processors and non-transitory computer-readable media storing instructions that, when executed by the processors, cause the processors to perform operations including obtaining a first setpoint trajectory from a cloud computation system. The first setpoint trajectory includes setpoints for the building equipment or for a space of the building. The setpoints correspond to time steps of an optimization period. The operations include determining whether a connection between the controller and the cloud computation system is active or inactive at a time step of the optimization period and determining an active setpoint for the time step of the optimization period using either the first or second setpoint trajectory based on whether the connection between the controller and the cloud computation system is active or inactive at the time step. The operations include operating the building equipment based on the active setpoint.