Patents by Inventor Matthew J. Giacalone

Matthew J. Giacalone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IONIZING IRRADIATION STERILIZATION OF BACTERIAL MINICELL-BASED BIOPHARMACEUTICALS AND METHODS OF USE
    Publication number: 20230321159
    Abstract: Disclosed herein are methods of terminally sterilizing bacterial minicells or compositions comprising bacterial minicells by exposure to ionizing irradiation. Also disclosed are terminally sterilized bacterial minicells, pharmaceutical compositions comprising the bacterial minicells, and methods of using the bacterial minicells and pharmaceutical compositions.
    Type: Application
    Filed: January 30, 2023
    Publication date: October 12, 2023
    Inventors: Matthew J. Giacalone, Gary H. Ward
  • Ionizing irradiation sterilization of bacterial minicell-based biopharmaceuticals and methods of use
    Patent number: 11564953
    Abstract: Disclosed herein are methods of terminally sterilizing bacterial minicells or compositions comprising bacterial minicells by exposure to ionizing irradiation. Also disclosed are terminally sterilized bacterial minicells, pharmaceutical compositions comprising the bacterial minicells, and methods of use the bacterial minicells and pharmaceutical compositions.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: January 31, 2023
    Assignee: VAXIION THERAPEUTICS, LLC
    Inventors: Matthew J. Giacalone, Gary H. Ward
  • IMMUNOMODULATORY & ONCOLYTIC MINICELLS AND METHODS OF USE
    Publication number: 20220054585
    Abstract: Disclosed herein are compositions comprising immunomodulatory and oncolytic eubacterial minicells, and the use of the composition in immunomodulatory therapies for cancer. In some embodiments, the minicells are used in combination of immune checkpoint inhibitors in treating cancer.
    Type: Application
    Filed: November 5, 2021
    Publication date: February 24, 2022
    Inventor: Matthew J. Giacalone
  • Immunomodulatory minicells and methods of use
    Patent number: 11219679
    Abstract: The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: January 11, 2022
    Assignee: VAXIION THERAPEUTICS, LLC
    Inventor: Matthew J. Giacalone
  • Immunomodulatory and oncolytic minicells and methods of use
    Patent number: 11167008
    Abstract: Disclosed herein are compositions comprising immunomodulatory and oncolytic eubacterial minicells, and the use of the composition in immunomodulatory therapies for cancer. In some embodiments, the minicells are used in combination of immune checkpoint inhibitors in treating cancer.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: November 9, 2021
    Assignee: VAXIION THERAPEUTICS, LLC
    Inventor: Matthew J. Giacalone
  • IMMUNOMODULATORY MINICELLS AND METHODS OF USE
    Publication number: 20210052715
    Abstract: The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
    Type: Application
    Filed: February 17, 2020
    Publication date: February 25, 2021
    Applicant: Vaxiion Therapeutics, LLC
    Inventor: Matthew J. GIACALONE
  • Therapeutic compositions and methods for antibody and Fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells
    Patent number: 10919942
    Abstract: The present application relates to the use of bacterial minicells as targeted delivery agents in vivo and in vitro. Described herein are genetically engineered eubacterial minicells designed to preferentially target and deliver therapeutically relevant agents using a minicell surface coupling molecule capable of binding and displaying antibodies or other Fc-containing targeting moiety fusions and conjugates.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: February 16, 2021
    Assignee: VAXIION THERAPEUTICS, LLC
    Inventors: Matthew J. Giacalone, Michael J. Newman
  • Immunomodulatory minicells and methods of use
    Patent number: 10561719
    Abstract: The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: February 18, 2020
    Assignee: Vaxiion Therapeautics, LLC
    Inventor: Matthew J. Giacalone
  • IONIZING IRRADIATION STERILIZATION OF BACTERIAL MINICELL-BASED BIOPHARMACEUTICALS AND METHODS OF USE
    Publication number: 20190282629
    Abstract: Disclosed herein are methods of terminally sterilizing bacterial minicells or compositions comprising bacterial minicells by exposure to ionizing irradiation. Also disclosed are terminally sterilized bacterial minicells, pharmaceutical compositions comprising the bacterial minicells, and methods of use the bacterial minicells and pharmaceutical compositions.
    Type: Application
    Filed: November 9, 2018
    Publication date: September 19, 2019
    Inventors: Matthew J. Giacalone, Gary H. Ward
  • IMMUNOMODULATORY MINICELLS AND METHODS OF USE
    Publication number: 20190167778
    Abstract: The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
    Type: Application
    Filed: August 1, 2018
    Publication date: June 6, 2019
    Inventor: Matthew J. Giacalone
  • THERAPEUTIC COMPOSITIONS AND METHODS FOR ANTIBODY AND FC-CONTAINING TARGETING MOLECULE-BASED TARGETED DELIVERY OF BIOACTIVE MOLECULES BY BACTERIAL MINICELLS
    Publication number: 20190002507
    Abstract: The present application relates to the use of bacterial minicells as targeted delivery agents in vivo and in vitro. Described herein are genetically engineered eubacterial minicells designed to preferentially target and deliver therapeutically relevant agents using a minicell surface coupling molecule capable of binding and displaying antibodies or other Fc-containing targeting moiety fusions and conjugates.
    Type: Application
    Filed: June 7, 2018
    Publication date: January 3, 2019
    Inventors: Matthew J. Giacalone, Michael J. Newman
  • Ionizing irradiation sterilization of bacterial minicell-based biopharmaceuticals and methods of use
    Patent number: 10124024
    Abstract: Disclosed herein are methods of terminally sterilizing bacterial minicells or compositions comprising bacterial minicells by exposure to ionizing irradiation. Also disclosed are terminally sterilized bacterial minicells, pharmaceutical compositions comprising the bacterial minicells, and methods of use the bacterial minicells and pharmaceutical compositions.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: November 13, 2018
    Assignee: Vaxiion Therapeutics, LLC
    Inventors: Matthew J. Giacalone, Gary H. Ward
  • Immunomodulatory minicells and methods of use
    Patent number: 10039817
    Abstract: The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: August 7, 2018
    Assignee: Vaxiion Therapeutics, LLC
    Inventor: Matthew J. Giacalone
  • Therapeutic compositions and methods for antibody and Fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells
    Patent number: 10005820
    Abstract: The present application relates to the use of bacterial minicells as targeted delivery agents in vivo and in vitro. Described herein are genetically engineered eubacterial minicells designed to preferentially target and deliver therapeutically relevant agents using a minicell surface coupling molecule capable of binding and displaying antibodies or other Fc-containing targeting moiety fusions and conjugates.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: June 26, 2018
    Assignee: VAXIION THERAPEUTICS, LLC
    Inventors: Matthew J. Giacalone, Michael J. Newman
  • IONIZING IRRADIATION STERILIZATION OF BACTERIAL MINICELL-BASED BIOPHARMACEUTICALS AND METHODS OF USE
    Publication number: 20180153942
    Abstract: Disclosed herein are methods of terminally sterilizing bacterial minicells or compositions comprising bacterial minicells by exposure to ionizing irradiation. Also disclosed are terminally sterilized bacterial minicells, pharmaceutical compositions comprising the bacterial minicells, and methods of use the bacterial minicells and pharmaceutical compositions.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 7, 2018
    Inventors: Matthew J. Giacalone, Gary H. Ward
  • IMMUNOMODULATORY & ONCOLYTIC MINICELLS AND METHODS OF USE
    Publication number: 20180140665
    Abstract: Disclosed herein are compositions comprising immunomodulatory and oncolytic eubacterial minicells, and the use of the composition in immunomodulatory therapies for cancer. In some embodiments, the minicells are used in combination of immune checkpoint inhibitors in treating cancer.
    Type: Application
    Filed: November 21, 2017
    Publication date: May 24, 2018
    Inventor: Matthew J. Giacalone
  • REGULATED GENETIC SUICIDE MECHANISM COMPOSITIONS AND METHODS
    Publication number: 20170224625
    Abstract: Embodiments of the present invention relates to the incorporation and use of a regulated genetic suicide mechanism for use in the improved purification of biologics, including adjunct use in various eubacterial minicell production and purification methodologies. Described herein are high-yield eubacterial minicell-producing strains with genetic modifications that comprise a regulated genetic suicide mechanism that irreparably destroys the parent cell chromosome such that live parental cells in a culture can be functionally eliminated at any time during the course of a minicell production and purification run. Embodiments of the present invention also describe methods useful in the elimination of live parental cells during the production of other cell-based biologics.
    Type: Application
    Filed: February 13, 2017
    Publication date: August 10, 2017
    Inventors: Matthew J. Giacalone, Stanley Maloy, Shingo Tsuji
  • IMMUNOMODULATORY MINICELLS AND METHODS OF USE
    Publication number: 20170143815
    Abstract: The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
    Type: Application
    Filed: February 6, 2017
    Publication date: May 25, 2017
    Inventor: Matthew J. Giacalone
  • Regulated genetic suicide mechanism compositions and methods
    Patent number: 9574196
    Abstract: Embodiments of the present invention relates to the incorporation and use of a regulated genetic suicide mechanism for use in the improved purification of biologics, including adjunct use in various eubacterial minicell production and purification methodologies. Described herein are high-yield eubacterial minicell-producing strains with genetic modifications that comprise a regulated genetic suicide mechanism that irreparably destroys the parent cell chromosome such that live parental cells in a culture can be functionally eliminated at any time during the course of a minicell production and purification run. Embodiments of the present invention also describe methods useful in the elimination of live parental cells during the production of other cell-based biologics.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: February 21, 2017
    Assignee: Vaxiion Therapeutics, LLC
    Inventors: Matthew J Giacalone, Stanley Maloy, Shingo Tsuji
  • Immunomodulatory minicells and methods of use
    Patent number: 9566321
    Abstract: The present disclosure is related to immunomodulatory bacterial minicells and methods of using the minicells.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: February 14, 2017
    Assignee: VAXIION THERAPEUTICS, LLC
    Inventor: Matthew J. Giacalone