Patents by Inventor Matthew Jacob Powell
Matthew Jacob Powell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210096138Abstract: The use of matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) to assay feline tissue samples is described. Methods of analyzing a tissue sample may generally comprise generating sample ions directly from the tissue sample using a MALDI ionization source, receiving the ions into a mass spectrometer, identifying at least one inflammatory bowel disease and/or lymphoma related compound in the sample from results from the mass spectrometer, comparing the at least one identified related compound in the sample to one or more known inflammatory bowel disease and/or lymphoma profiles, and identifying at least one condition related to the sample from the comparison of the at least one identified related compound to the one or more known inflammatory bowel disease and/or lymphoma profiles. The mass spectrometer may be a quadrupole mass spectrometer, a time of flight mass spectrometer, an Orbitrap mass spectrometer, or an ion trap mass spectrometer.Type: ApplicationFiled: September 30, 2019Publication date: April 1, 2021Inventors: Katy Ryan Smoot, Matthew Jacob Powell, Joerg Manfred Steiner, Sina Marsilio
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Patent number: 9206226Abstract: A compound may generally comprise the formula: wherein R1 is independently selected from C2-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, X is selected from the group consisting of —NH— and —O—, Y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant. The compound may be used to facilitate solubilization of proteins and other molecules in an aqueous environment.Type: GrantFiled: June 23, 2014Date of Patent: December 8, 2015Assignee: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust T. Razunguzwa, Miaosheng Li
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Publication number: 20140302554Abstract: A compound may generally comprise the formula: wherein R1 is independently selected from C2-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, X is selected from the group consisting of —NH— and —O—, Y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant. The compound may be used to facilitate solubilization of proteins and other molecules in an aqueous environment.Type: ApplicationFiled: June 23, 2014Publication date: October 9, 2014Inventors: Matthew Jacob Powell, Trust T. Razunguzwa, Miaosheng Li
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Patent number: 8791251Abstract: A compound may generally comprise the formula: wherein R1 is independently selected from C2-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, X is selected from the group consisting of —NH— and —O—, Y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant. The compound may be used to facilitate solubilization of proteins and other molecules in an aqueous environment.Type: GrantFiled: June 1, 2012Date of Patent: July 29, 2014Assignee: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust T. Razunguzwa, Miaosheng Li
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Patent number: 8445223Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.Type: GrantFiled: June 25, 2012Date of Patent: May 21, 2013Assignee: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Patent number: 8435756Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.Type: GrantFiled: June 25, 2012Date of Patent: May 7, 2013Assignee: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Publication number: 20120309954Abstract: A compound may generally comprise the formula: wherein R1 is independently selected from C2-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, X is selected from the group consisting of —NH— and —O—, Y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant. The compound may be used to facilitate solubilization of proteins and other molecules in an aqueous environment.Type: ApplicationFiled: June 1, 2012Publication date: December 6, 2012Inventors: Matthew Jacob Powell, Trust T. Razunguzwa, Miaosheng Li
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Publication number: 20120264157Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.Type: ApplicationFiled: June 25, 2012Publication date: October 18, 2012Applicant: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Publication number: 20120264158Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.Type: ApplicationFiled: June 25, 2012Publication date: October 18, 2012Applicant: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Patent number: 8232423Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilization of proteins and other molecules in an aqueous environment.Type: GrantFiled: August 1, 2011Date of Patent: July 31, 2012Assignee: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Publication number: 20110282096Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilisation of proteins and other molecules in an aqueous environment.Type: ApplicationFiled: August 1, 2011Publication date: November 17, 2011Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Publication number: 20110250641Abstract: A compound of the formula: wherein R1 is independently selected from C1-C10 alkyl or substituted alkyl, R2 is independently selected from the group consisting of —H and C1-C6 alkyl or substituted alkyl, Y? is an anion, m is an integer from 1 to 8 and n is an integer from 1 to 8 is described. Methods of making and using the compound are also described. The compound may comprise a zwitterionic acid-labile surfactant suitable for purification and identification techniques used in proteomics.Type: ApplicationFiled: April 7, 2011Publication date: October 13, 2011Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Patent number: 8013179Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formulas: and wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also disclosed.Type: GrantFiled: May 22, 2009Date of Patent: September 6, 2011Assignee: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Publication number: 20090292136Abstract: Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R1 is independently selected from —(CH2)0-9CH3, R2 is selected from the group consisting of —H and —(CH2)0-5CH3, Y is an anion, X is a cation, and n is an integer from 1 to 8.Type: ApplicationFiled: May 22, 2009Publication date: November 26, 2009Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, George Augustine O'Doherty, Miaosheng Li
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Publication number: 20090250345Abstract: A microfluidic device for electroelution with sample collection decoupled from the electrophoretic field can generally comprise a channel having a first fluid pathway in fluid communication with a second fluid pathway, the first fluid pathway can comprise a first port in fluid communication with a second port, and a receptacle intermediate the ports, the second fluid pathway can comprise an inlet in fluid communication with an outlet, the first and second ports can be associated with first and second electrodes, respectively, such that the electrodes can create an electrophoretic field across the receptacle, and the channel can be configured to create a pressure drop from the first fluid pathway towards the second fluid pathway that encourages the electroeluted sample to flow towards the second fluid pathway.Type: ApplicationFiled: April 3, 2008Publication date: October 8, 2009Inventors: Matthew Jacob Powell, Jifeng Chen, Trust Tariro Razunguzwa
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Publication number: 20090250347Abstract: A microfluidic device for collecting a sample during electrokinetic transport may generally comprise a first channel intersecting a second channel to form a junction; a receptacle in fluid communication with the first channel to receive therein a sample comprising at least one analyte; a pair of electrodes associated with the first channel to create an electrophoretic field effective to electrokinetically transport the at least one analyte, wherein the second channel is substantially field-free of the electrophoretic field; and a first reservoir and a second reservoir in fluid communication with the first channel to create a pressure gradient between the channels effective to transport the at least one analyte from the first channel to the second channel when fluid is present in at least one of the reservoirs and the voltage is substantially simultaneously applied along the first channel.Type: ApplicationFiled: November 17, 2008Publication date: October 8, 2009Applicant: Protea Biosciences, Inc.Inventors: Matthew Jacob Powell, Trust Tariro Razunguzwa, Jifeng Chen