Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: A working machine comprising a hydraulic fluid circuit an operator structure and a thermal management system. The thermal management system connects an operator structure heater and a heat exchanger arranged to selectively remove heat energy from the hydraulic fluid circuit, so as to be capable transferring heat from the hydraulic fluid to the operator structure.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: Provided herein is a digital care circle platform for electronic communication between a senior and virtual care circle members. The digital care circle platform may include a chatbot and an application associated with the senior, a mobile application associated with the plurality of virtual care circle members, at least one processor in communication with at least one memory device, and one or more servers, sensors, wearables, and transceivers. The at least one processor may be configured to: (i) accept event posts from the senior via the chatbot and application and from each virtual care circle member of the plurality of virtual care circle members via the mobile application, (ii) detect pro-active check-ins from the senior, and (iii) generate, once a pro-active check-in is detected, an electronic communication detailing the pro-active check-in as a pro-active check-in event, and transmit the pro-active check-in event to the virtual care circle members.

Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.

Abstract: Techniques described herein provide multi-factor authentication based on positioning data. Generally described, configurations disclosed herein enable a system to authorize a particular action using positioning data, and possibly other data, associated with an identity. For example, when a user wishes to change a password or access a secured account, the system can authenticate a user if a device associated with the user is located in the secure area. The system can authenticate a user if a requested operation and/or a predetermined pattern of movement associated with the user is detected. For instance, the system allows the user to change the password when the user's computer has followed a predetermined pattern of movement, and when one or more verification procedures meets one or more criteria while the location of the computing device is within the predetermined area.

Abstract: Methods of treating a subject having heart failure including heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, and left ventricular hypertrophy-induced heart failure. The methods include activating hypothalamic oxytocin neurons in the brain of the subject and/or administering intranasally to the subject a therapeutically effective amount of oxytocin. Intranasal formulations for the treatment of a subject diagnosed with heart failure are also provided.

Abstract: Techniques described herein provide multi-factor authentication based on positioning data. Generally described, configurations disclosed herein enable a system to authorize a particular action using positioning data, and possibly other data, associated with an identity. For example, when a user wishes to change a password or access a secured account, the system can authenticate a user if a device associated with the user is located in the secure area. The system can authenticate a user if a requested operation and/or a predetermined pattern of movement associated with the user is detected. For instance, the system allows the user to change the password when the user's computer has followed a predetermined pattern of movement, and when one or more verification procedures meets one or more criteria while the location of the computing device is within the predetermined area.

Abstract: Methods and systems are described for managing a user's contact data which use evolving sequential sets of rules where the applicability of each set depends upon adherence or proper application of a prior set. In an embodiment, an initial set of restrictions are generated based on input from a first user, the restrictions relating to contact made by a second user to the first user. These initial restrictions are subsequently modified in response to the second user contacting the first user based on the contact made and a characteristic of the contact. The methods may apply to any form of contact between the first and second users and in an embodiment applies to contact made by the second user to a cellular telephone number belonging to the first user.

Abstract: Techniques described herein provide location-based access control to secured resources. Generally described, configurations disclosed herein enable a system to dynamically modify access to secured resources based on one or more location-related actions. For example, techniques disclosed herein can enable a computing system to control access to resources such as computing devices, display devices, secured locations, and secured data. In some configurations, the techniques disclosed herein can enable controlled access to secured resources based, at least in part, on an invitation associated with a location and positioning data indicating a location of a user.

Abstract: Methods of treating a subject having heart failure including heart failure with reduced ejection fraction, heart failure with preserved ejection fraction, and left ventricular hypertrophy-induced heart failure. The methods include activating hypothalamic oxytocin neurons in the brain of the subject and/or administering intranasally to the subject a therapeutically effective amount of oxytocin. Intranasal formulations for the treatment of a subject diagnosed with heart failure are also provided.

Abstract: Techniques described herein provide multi-factor authentication based on positioning data. Generally described, configurations disclosed herein enable a system to authorize a particular action using positioning data, and possibly other data, associated with an identity. For example, when a user wishes to change a password or access a secured account, the system can authenticate a user if a device associated with the user is located in the secure area. The system can authenticate a user if a requested operation and/or a predetermined pattern of movement associated with the user is detected. For instance, the system allows the user to change the password when the user's computer has followed a predetermined pattern of movement, and when one or more verification procedures meets one or more criteria while the location of the computing device is within the predetermined area.

Abstract: Techniques described herein provide multi-factor authentication based on positioning data. Generally described, configurations disclosed herein enable a system to authorize a particular action using positioning data, and possibly other data, associated with an identity. For example, when a user wishes to change a password or access a secured account, the system can authenticate a user if a device associated with the user is located in the secure area. The system can authenticate a user if a requested operation and/or a predetermined pattern of movement associated with the user is detected. For instance, the system allows the user to change the password when the user's computer has followed a predetermined pattern of movement, and when one or more verification procedures meets one or more criteria while the location of the computing device is within the predetermined area.

Abstract: Apparatuses and methods using current-starved ring oscillator biased by floating gate transistors with a variety of applications including as a power-free radiation detector or silicon age determination or odometer system.

Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.

Abstract: Exemplary systems and methods for inhibiting backend access to an integrated circuit are provided including latch-up circuits triggered by photons, electrons, and ions to create catastrophic failures in integrated circuits. Exemplary systems include latch-up circuits with floating gate bit cells which, when triggered, close the latch-up circuits so that the latch-up circuits can amplify current in a positive feedback loop to create a short circuit to inhibit unauthorized individuals from probing or modifying an integrated circuit.

Abstract: Methods and systems are described for managing a user's contact data which use evolving sequential sets of rules where the applicability of each set depends upon adherence or proper application of a prior set. In an embodiment, an initial set of restrictions are generated based on input from a first user, the restrictions relating to contact made by a second user to the first user. These initial restrictions are subsequently modified in response to the second user contacting the first user based on the contact made and a characteristic of the contact. The methods may apply to any form of contact between the first and second users and in an embodiment applies to contact made by the second user to a cellular telephone number belonging to the first user.

Abstract: Methods and systems are described for managing a user's contact data which use evolving sequential sets of rules where the applicability of each set depends upon adherence or proper application of a prior set. In an embodiment, an initial set of restrictions are generated based on input from a first user, the restrictions relating to contact made by a second user to the first user. These initial restrictions are subsequently modified in response to the second user contacting the first user based on the contact made and a characteristic of the contact. The methods may apply to any form of contact between the first and second users and in an embodiment applies to contact made by the second user to a cellular telephone number belonging to the first user.

Abstract: Exemplary systems and methods for inhibiting backend access to an integrated circuit are provided including latch-up circuits triggered by photons, electrons, and ions to create catastrophic failures in integrated circuits. Exemplary systems include latch-up circuits with floating gate bit cells which, when triggered, close the latch-up circuits so that the latch-up circuits can amplify current in a positive feedback loop to create a short circuit to inhibit unauthorized individuals from probing or modifying an integrated circuit.