Abstract: Embodiments described herein relate generally to continuous flow photoreactors with easily replaceable and adjustable components. The photoreactor includes a reactor flow system, a lighting system, and a temperature control system. The reactor flow system includes a reactor inlet port, a reactor outlet port, and a length of reactor tubing fluidically coupled to the reactor inlet port and reactor outlet port. The lighting system includes a light emitting apparatus (e.g., a plurality of LEDs) configured to emit light in a defined wavelength range toward the length of reactor tubing. The temperature control system includes an inlet port, an outlet port, and a length of temperature control tubing fluidically coupled to the inlet port and the outlet port. In some embodiments, the temperature control system can be configured to circulate a fluid to cool the lighting system.

Abstract: Described herein are boron-containing compounds, compositions, and methods for their preparation.

Abstract: Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.

Abstract: Described herein are boron-containing compounds, compositions, and methods for their preparation.

Abstract: Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.

Abstract: Embodiments described herein relate generally to continuous flow photoreactors with easily replaceable and adjustable components. The photoreactor includes a reactor flow system, a lighting system, and a temperature control system. The reactor flow system includes a reactor inlet port, a reactor outlet port, and a length of reactor tubing fluidically coupled to the reactor inlet port and reactor outlet port. The lighting system includes a light emitting apparatus (e.g., a plurality of LEDs) configured to emit light in a defined wavelength range toward the length of reactor tubing. The temperature control system includes an inlet port, an outlet port, and a length of temperature control tubing fluidically coupled to the inlet port and the outlet port. In some embodiments, the temperature control system can be configured to circulate a fluid to cool the lighting system.

Abstract: Described herein are boron-containing compounds, compositions, and methods for their preparation.

Abstract: Described herein are boron-containing compounds, compositions, and methods for their preparation.

Abstract: A process is provided for the preparation of branched-chain ribonucleosides of formula (I): from the 1,2-anhydroderivatives of formula (II). wherein PG is a hydroxyl protecting group, B is a purine or pyrimidine nucleobase, and R1 is C1-6 alkyl. The compounds of formula (I) are inhibitors of HCV polymerase useful in the treatment of HCV infection.