Patents by Inventor Matthew M. Cadin

Matthew M. Cadin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
    Patent number: 8809024
    Abstract: A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: August 19, 2014
    Assignee: AstraZeneca AB
    Inventors: Michael Politino, Matthew M. Cadin, Jason G. Chen
  • Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
    Patent number: 8361761
    Abstract: A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
    Type: Grant
    Filed: June 14, 2012
    Date of Patent: January 29, 2013
    Assignee: Bristol Myers-Squibb Company
    Inventors: Michael Politino, Matthew M. Cadin, Paul M. Skonezny, Jason G. Chen
  • Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor
    Publication number: 20120276600
    Abstract: A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine
    Type: Application
    Filed: June 14, 2012
    Publication date: November 1, 2012
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Michael Politino, Matthew M. Cadin, Paul M. Skonezny, Jason G. Chen
  • Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
    Patent number: 8222009
    Abstract: A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: July 17, 2012
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael Politino, Matthew M. Cadin, Paul M. Skonezny, Jason G. Chen
  • Process For Preparing Dipeptidyl Peptidase IV Inhibitors And Intermediates Therefor
    Publication number: 20100291642
    Abstract: A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
    Type: Application
    Filed: June 17, 2010
    Publication date: November 18, 2010
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Michael Politino, Matthew M. Cadin, Paul M. Skonezny, Jason G. Chen
  • Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
    Patent number: 7741082
    Abstract: A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure prepared by subjecting an acid of the structure to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure 2 with di-tert-butyl dicarbonate to form the BOC-protected amine.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: June 22, 2010
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael Politino, Matthew M. Cadin, Paul M. Skonezny, Jason G. Chen